Publication Information

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'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rpob', 'display_name': 'rpoB', 'score': 0.9065198}], 'concepts': [{'id': 'https://openalex.org/C2778340795', 'wikidata': 'https://www.wikidata.org/wiki/Q24782946', 'display_name': 'rpoB', 'level': 4, 'score': 0.9065198}, {'id': 'https://openalex.org/C2776228421', 'wikidata': 'https://www.wikidata.org/wiki/Q412318', 'display_name': 'Ethambutol', 'level': 4, 'score': 0.7273678}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.69149065}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.633049}, {'id': 'https://openalex.org/C2778607973', 'wikidata': 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'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.3760/cma.j.issn.0253-2352.2018.02.007', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3142620349', 'https://openalex.org/W3032001882', 'https://openalex.org/W3031310136', 'https://openalex.org/W2417508758', 'https://openalex.org/W2417375251', 'https://openalex.org/W2405210645', 'https://openalex.org/W2390522628', 'https://openalex.org/W2390371915', 'https://openalex.org/W2388825000', 'https://openalex.org/W2383317470', 'https://openalex.org/W2379743188', 'https://openalex.org/W2373701769', 'https://openalex.org/W2369183196', 'https://openalex.org/W2363029564', 'https://openalex.org/W2361835020', 'https://openalex.org/W2348549304', 'https://openalex.org/W2347346935', 'https://openalex.org/W2144611551', 'https://openalex.org/W2061775920', 'https://openalex.org/W2030832784'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'evaluate': [1, 101], 'the': [2, 11, 48, 53, 102, 107, 117, 134, 140, 155, 167, 176, 193, 202, 217, 222, 232, 241, 257, 266, 275, 282, 289, 311], 'sensitivity': [3, 49, 103, 158, 168, 194, 220, 233, 258, 267, 290, 328], 'and': [4, 16, 39, 50, 68, 80, 87, 93, 104, 124, 171, 197, 236, 270, 296, 303, 331, 341, 352, 359], 'specificity': [5, 51, 105, 172, 198, 237, 271, 297, 332, 360], 'of': [6, 14, 20, 29, 52, 58, 77, 83, 106, 121, 162, 256, 291, 344], 'Tag': [7], 'Array': [8, 335], 'in': [9, 26, 111, 116, 133, 151, 187, 213, 216, 224, 229, 252, 263, 306, 321], 'detecting': [10], 'clinical': [12, 60, 350], 'isolates': [13, 61], 'bone': [15, 67], 'joint': [17, 69], 'tuberculosis.\r\n\r\n\r\nMethods\r\nTwenty-four': [18], 'strains': [19, 76, 82, 148, 161, 184, 210, 249, 259, 286, 318], 'Mycobacterium': [21], 'tuberculosis': [22, 345], 'having': [23], 'sequence': [24], 'differences': [25], 'extracted': [27], 'plasmids': [28], 'mutant': [30], 'strains.': [31], 'The': [32], 'plasmid': [33], 'was': [34, 44, 169, 173, 195, 199, 227, 234, 238, 268, 272, 294, 298, 329, 333], 'diluted': [35], 'into': [36], 'different': [37], 'concentrations,': [38], 'then': [40], 'multiplex': [41], 'PCR': [42], 'amplification': [43], 'performed': [45], 'to': [46, 100], 'analyze': [47], 'chip': [54, 89, 283, 292, 336], 'system.': [55], 'A': [56], 'total': [57], '187': [59], 'were': [62, 74, 98, 260], 'collected': [63], 'from': [64], 'patients': [65], 'with': [66, 113, 119, 136], 'tuberculosis.': [70], 'Among': [71, 139, 175, 201, 240, 274], 'them,': [72], 'there': [73], '50': [75], 'sensitive': [78], 'bacteria,': [79], '137': [81], 'drug-resistant.': [84], 'Designed,': [85], 'optimized': [86], 'prepared': [88], 'inspection': [90], 'system,': [91], 'sequencing': [92, 114], 'phenotypic': [94], 'drug': [95, 144, 180, 189, 206, 245, 279, 308, 314, 323], 'susceptibility': [96], 'results': [97], 'analyzed': [99], 'gene': [108, 164, 191, 325], 'chip.\r\n\r\n\r\nResults\r\nThe': [109], 'mutants': [110], 'accordance': [112], 'result': [115, 132], 'sets': [118, 128, 135], '1×103copy/μl': [120], 'template': [122], 'concentration': [123], 'above;': [125], 'while': [126], '29': [127], 'showed': [129, 165], 'false': [130], 'negative': [131], '1×102': [137], 'copy/μl.': [138], '126': [141], 'rifampicin': [142, 156], 'phenotype': [143, 157, 179, 205, 219, 244, 278, 313], 'resistance': [145, 181, 190, 207, 246, 280, 315, 324], 'strains,': [146, 159, 182, 208, 221, 231, 247, 281, 316], '119': [147], 'appeared': [149, 185, 211, 250, 287, 319], 'mutation': [150, 186, 212, 223, 251, 262, 320], 'rpoB': [152, 163], 'gene.': [153], 'In': [154], '9': [160], 'mutation,': [166, 288], '94.40%,': [170], '86.76%.': [174], '118': [177], 'isoniazid': [178], '109': [183], 'relevant': [188, 322], 'locus,': [192, 326], '92.37%,': [196], '81.16%.': [200], '44': [203], 'ethambutol': [204, 218], '27': [209], 'locus': [214, 225], 'embB306,': [215], 'embB306': [226], 'detected': [228, 261, 284], '6': [230], '61.36%,': [235], '95.80%.': [239], '102': [242], 'levofloxacin': [243], '81': [248], 'gyrA': [253, 264], 'gene,': [254, 265], '4': [255], '79.41%,': [269], '95.29%.': [273], '112': [276], 'streptomycin': [277], '101': [285], 'detection': [293, 343], '90.17%,': [295], '84.00%.': [299], 'Since': [300], 'amikacin,': [301], 'capreomycin': [302], 'kanamycin': [304], 'are': [305], 'cross': [307], 'resistance,': [309, 346], 'among': [310], '67': [312], '52': [317], 'its': [327], '79.10%': [330], '90.83%.\r\n\r\n\r\nConclusion\r\nTag': [334], 'can': [337], 'achieve': [338], 'rapid,': [339], 'accurate': [340], 'high-throughput': [342], 'which': [347], 'has': [348], 'important': [349], 'significance': [351], 'feasibility.\r\n\r\n\r\nKey': [353], 'words:': [354], '\r\nExtensively': [355], 'drug-resistant': [356], 'tuberculosis;\xa0Genetic': [357], 'testing;\xa0Sensitivity': [358]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029560773', 'counts_by_year': [], 'updated_date': '2024-12-06T10:33:44.958611', 'created_date': '2020-06-05'}