Title: Prevention of oxaliplatin - induced neuropathy by Ca gluconate in patients with advanced colorectal cancer
Abstract: Objective To assess the neuroprotectant effect of Ca gluconate against oxaliplatininduced neurotoxicity. Methods Fifty - nine patients were divided into two guoups randomly. Experimental group received chemotherapy and Ca gluconate, and control group only received chemotherapy.The infusion of Ca gluconate (1 g) was proceeded before and after oxaliplatin. Results Of all patients available, the incidences of neurotoxicity in experimental group and control group were 36.7%, 55.2% respectively (P < 0. 05). No difference of L - OHP cumulative dose was ovserved between the two groups (P 0.05). Conclusions The infusion of Ca gluconate can reduce the incidence of oxaliplatin - induced neurotoxicity effectively.
Key words:
Ca gluconate; Oxaliplatin ; Neurotoxicity; Prevention
Publication Year: 2009
Publication Date: 2009-07-25
Language: en
Type: article
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