Title: Efficacy of reduced glutathione in preventing and reducing neurotoxicity of oxaliplatin
Abstract: OBJECTIVE:To observe the efficacy of reduced glutathione in prevention and reduction of oxalipatin-inducted neurotoxicity.METHODS:Seventy-eight patients after gastic and colonrectal cancer resection treated with FOLFOX4 or mFOLFOX6 regimen were randomized into reduced glutathione group(GSH group) and control group.Forty patients were entered in GSH group and thirty-eight patients in control group.One day before chemotherapy with oxaliplatin,the day with chemotherapy and the day after chemotherapy,the GSH group patients received infusion of 1.8 g of reduced glutatione intravenously wtih NS 100 mL,while the control group patients received NS 100 mL in the three day with chemotherapy.The neurotoxity evaluation was performed before the treatment,after the fourth cycly,the eighth cycly and the twelfth cycle of treatment.The patients who had the neurotoxity symptoms were followed up for one year.The clinical sensory nervous system examination was checked every three months.RESULTS:After the fourth and the eithth cycle,the incidence of neurotoxicity between the two groups was not significantly different(P0.05).After the twelfth cycle,the incidence of grade 3 and 4 periphery neurotoxicity in the control group was 39.5%,and 5.3%.The incidence of grade 3 and 4 periphery neurotoxicity in the GSH group was 15%,and 0%.The incidence of grade 3 to 4 periphery neurotoxicity between the two groups was significantly different(P0.05).One year follow up,grade 2 to 4 periphery neurotoxicity was not observed in GSH group and the control group,but grade 1 periphery neurotoxicity was 9(23.7%) patients experienced in the control group compared with only 3(7.5%) patients in the GSH group(P0.05).CONCLUSION:Reduced glutatione is effective in prevention and reduction of periphery neurotoxicity of oxaliplatin.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 2
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