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{'id': 'https://openalex.org/W3029296261', 'doi': 'https://doi.org/10.3760/cma.j.issn.1671-0282.2019.06.013', 'title': 'Protective effect and mechanism of chemokine C-C motif ligand 6 on glucose and oxygen deprivation induced injury of cardiomyocytes', 'display_name': 'Protective effect and mechanism of chemokine C-C motif ligand 6 on glucose and oxygen deprivation induced injury of cardiomyocytes', 'publication_year': 2019, 'publication_date': '2019-06-10', 'ids': {'openalex': 'https://openalex.org/W3029296261', 'doi': 'https://doi.org/10.3760/cma.j.issn.1671-0282.2019.06.013', 'mag': '3029296261'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN114656201906/1153397.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764945285', 'display_name': 'Zhonghua jizhen yixue zazhi', 'issn_l': '1671-0282', 'issn': ['1671-0282'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 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'related_works': ['https://openalex.org/W3157685620', 'https://openalex.org/W3151175020', 'https://openalex.org/W3112081768', 'https://openalex.org/W3084398156', 'https://openalex.org/W3032672127', 'https://openalex.org/W3031453064', 'https://openalex.org/W3024886008', 'https://openalex.org/W3013296353', 'https://openalex.org/W3003870179', 'https://openalex.org/W2997370786', 'https://openalex.org/W2992714606', 'https://openalex.org/W2974367686', 'https://openalex.org/W2903715390', 'https://openalex.org/W2491740661', 'https://openalex.org/W2411539246', 'https://openalex.org/W2377670728', 'https://openalex.org/W2375260401', 'https://openalex.org/W2373193676', 'https://openalex.org/W2353274764', 'https://openalex.org/W2323688157'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'study': [1], 'the': [2, 28, 49, 53, 92, 106, 116, 121, 125, 190, 198], 'protective': [3], 'effect': [4], 'of': [5, 39, 94, 118, 124, 164, 182, 192, 200, 221, 225], 'chemokine': [6], 'C-C': [7], 'motif': [8], 'ligand': [9], '6': [10], '(CCL6)': [11], 'on': [12], 'glucose-oxygen': [13], 'deprivation': [14, 75, 134, 153], 'induced': [15, 135, 208], 'injury': [16, 68, 207], 'in': [17, 27, 48, 63, 120, 138, 142, 145, 185, 189], 'cardiomyocytes': [18, 60, 144, 183], 'and': [19, 36, 52, 65, 102, 111, 159, 169, 175, 195, 202, 212, 223], 'its': [20, 213], 'possible': [21], 'molecular': [22, 214], 'mechanism.\r\n\r\n\r\nMethods\r\nGene': [23], 'expression': [24, 38, 47, 93, 117, 140, 191], 'was': [25, 44, 70, 79, 85, 97, 128], 'analyzed': [26, 40, 45], 'public': [29], 'database': [30, 35], 'Gene': [31], 'Expression': [32], 'Omnibus': [33], '(GEO)': [34], 'gene': [37, 46], 'for': [41], 'myocardial': [42, 66, 122], 'tissue': [43, 123], 'sham': [50, 107], 'group': [51, 55, 127], 'ischemia-reperfusion': [54], '(IR': [56], 'group).': [57], 'Rat': [58], 'H9C2': [59, 143], 'were': [61], 'cultured': [62], 'vitro,': [64], 'cell': [67, 157, 167], 'model': [69], 'established': [71], 'by': [72, 81, 87, 99, 209], 'oxygen': [73, 151], 'glucose': [74, 133, 152, 210], '(OGD).': [76], 'Cell': [77], 'viability': [78, 158, 168], 'detected': [80, 98], 'MTT': [82], 'assay;': [83], 'apoptosis': [84], 'determined': [86], 'Annex': [88], 'V/PI': [89], 'double': [90], 'staining;': [91], 'related': [95, 218], 'genes': [96], 'real-time': [100, 112, 176], 'PCR': [101, 113, 177], 'Western': [103], 'blot.\r\n\r\n\r\nResults\r\nCompared': [104], 'with': [105], 'group,': [108], 'transcriptome': [109], 'analysis': [110], 'showed': [114, 178], 'that': [115, 179], 'CCL6': [119, 139, 165, 180], 'IR': [126], 'significantly': [129], 'decreased': [130, 156], '(P<0.01).': [131], 'Oxygen': [132], 'a': [136, 146, 186], 'decrease': [137, 188], 'levels': [141], 'time-dependent': [147], 'manner.': [148], 'In': [149], 'addition,': [150], 'leads': [154], 'to': [155, 219], 'increased': [160, 197], 'apoptosis;': [161], 'while': [162], 'addition': [163], 'promotes': [166], 'reduces': [170], 'apoptosis.': [171], 'The': [172], 'lncRNA': [173, 193], 'microarray': [174], 'treatment': [181], 'resulted': [184], 'significant': [187], 'IGF2-AS': [194, 222], 'further': [196], 'phosphorylation': [199], 'Akt': [201], 'GSK-3β.\r\n\r\n\r\nConclusion\r\nCCL6': [203], 'can': [204], 'inhibit': [205], 'cardiomyocyte': [206], 'deprivation,': [211], 'mechanism': [215], 'may': [216], 'be': [217], 'inhibition': [220], 'enhancement': [224], 'Akt/GSK-3β': [226], 'signaling': [227], 'pathway.\r\n\r\n\r\nKey': [228], 'words:': [229], '\r\nCardiomyocytes;\xa0Chemokine;\xa0Apoptosis': [230]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029296261', 'counts_by_year': [], 'updated_date': '2024-12-24T07:13:40.721558', 'created_date': '2020-06-05'}