Title: Relationship between serum level of TGF-β1 and hepatic fibrosis in patients with chronic hepatitis B
Abstract: Objective To study the relationship between serum level of TGF-β1 and hepatic fibrosis parameters in patients with chronic hepatitis B. Methods Serum TGF-β1 and hyalauronic acid(HA), laminin (LN), type Ⅳ collagen(Ⅳ-C) and type Ⅲ procollagen (PC Ⅲ) were detected by ELISA in 38 patients with chronic hepatitis B (CHB). Ten healthy persons served as controls. Liver puncture was performed in all patients with CHB. Results Serum TGF-β1 levels in moderate, severe CHB [(202±78)mg/L,(401±63)mg/L] were much higher than those of the control group [(75±34)mg/L,P<0.01] and increased successively. TGF-β1 was correlated positively with serum levels of HA,LN,Ⅳ-C and PC Ⅲ (P<0.01). Serum TGF-β1, PCⅢ, LN, Ⅳ-C and HA increased successively (P<0.01) with aggravation of hepatic fibrosis. Conclusions Serum TGF-β1 levels of patients with CHB are consistent with serum indexes of hepatic fibrosis. It can help to judge the degree of hepatic tissue fibrosis.
Key words:
Transforming growth factor-β1 ; Hepatic fibrosis ; Chronic hepatitis B ; Extracellular matrix ;
Publication Year: 2010
Publication Date: 2010-12-25
Language: en
Type: article
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