Title: Effect of Sophocarpidine Combined with Interferon on Chronic Hepatic Fibrosis and Serum Content of Interferon Gamma in Patients with chronic Type B Hepatitis
Abstract: Objective:To study the effect of sophocarpidine combined with interferon on hepatic fibrosis and the serum content of interferon gamma(IFN-γ) in chronic hepatitis B(CHB) patients.Methods:A total of 126 CHB patients were randomly divided into two groups.The treatment group(n=66)was given sophocarpidine and interferon,and the control group(n=60) was given interferon.After treatment for 6 months,hepatic function,hepatitis B virus(HBV) serum markers,hepatic fibrosis indexes and IFN-γ were measured.Meanwhile,the pathological changes of hepatic tissue were examined.Results:The serum levels of alanine amino transferase(ALT),aspartate amino transferase(AST),hyaluronic acid(HA),precollagen Ⅲ(PCⅢ),laminin(LN) and collogen IV(CⅣ) were decreased,and the albumin globulin ratio(A/G) as well as the serum content of IFN-γ was increased in both groups after treatment(P 0.01 compared with those before treatment).The decrease of serum ALT,AST,HA,PCⅢ and CⅣ was obvious in the treatment group(P 0.05 compared with that in the control group).The rate for HBV-DNA turning negative was higher(P 0.05) and the rate for HBeAg turning negative was lower in the control group(P 0.01) than those in the treatment group.The pathological changes in the liver tissue of the treatment group were significantly improved.Conclusion:Sophocarpidine combined with interferon could increase the content of IFN-γ,inhibit hepatic fibrosis and viral replication,decrease aminotransferase and improve liver function.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot