Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation

Name: Work Video:
Duration: 3 min 30 s
Audrey Le Floc’h; Jeanne Allinne; Kirsten Nagashima; George Scott; Dylan Birchard; Seblewongel Asrat; Yu Bai; Wei Keat Lim; Joel Martin; Tammy Huang; Terra Potocky; Jeeho Kim; Ashique Rafique; Nicholas Papadopoulos; Neil Stahl; George D. Yancopoulos; Andrew Murphy; Matthew A. Sleeman; Jamie Orengo
{'id': 'https://openalex.org/W2996174934', 'doi': 'https://doi.org/10.1111/all.14151', 'title': 'Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation', 'display_name': 'Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation', 'publication_year': 2019, 'publication_date': '2019-12-15', 'ids': {'openalex': 'https://openalex.org/W2996174934', 'doi': 'https://doi.org/10.1111/all.14151', 'mag': '2996174934', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31838750', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7317958'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/all.14151', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14151', 'source': {'id': 'https://openalex.org/S68090385', 'display_name': 'Allergy', 'issn_l': '0105-4538', 'issn': ['0105-4538', '1398-9995'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14151', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075450178', 'display_name': 'Audrey Le Floc’h', 'orcid': 'https://orcid.org/0000-0001-5377-6791'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Audrey Le Floc’h', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022086818', 'display_name': 'Jeanne Allinne', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeanne Allinne', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113036579', 'display_name': 'Kirsten Nagashima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kirsten Nagashima', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059053054', 'display_name': 'George Scott', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Scott', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027502675', 'display_name': 'Dylan Birchard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dylan Birchard', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018281721', 'display_name': 'Seblewongel Asrat', 'orcid': 'https://orcid.org/0000-0001-9953-7120'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Seblewongel Asrat', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068335766', 'display_name': 'Yu Bai', 'orcid': 'https://orcid.org/0000-0002-0371-8590'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yu Bai', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087635680', 'display_name': 'Wei Keat Lim', 'orcid': 'https://orcid.org/0000-0002-6226-2570'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Keat Lim', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037209746', 'display_name': 'Joel Martin', 'orcid': 'https://orcid.org/0000-0002-0507-9390'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joel Martin', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008369148', 'display_name': 'Tammy Huang', 'orcid': 'https://orcid.org/0000-0003-0127-4743'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tammy Huang', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004345979', 'display_name': 'Terra Potocky', 'orcid': 'https://orcid.org/0000-0002-6981-9597'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Terra B. Potocky', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017671136', 'display_name': 'Jeeho Kim', 'orcid': 'https://orcid.org/0000-0001-6869-3606'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jee H. Kim', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003106049', 'display_name': 'Ashique Rafique', 'orcid': 'https://orcid.org/0000-0003-4078-7242'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ashique Rafique', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002173891', 'display_name': 'Nicholas Papadopoulos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicholas J. Papadopoulos', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083524146', 'display_name': 'Neil Stahl', 'orcid': 'https://orcid.org/0000-0001-7265-2575'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Neil Stahl', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085672493', 'display_name': 'George D. Yancopoulos', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George D. Yancopoulos', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101917021', 'display_name': 'Andrew Murphy', 'orcid': 'https://orcid.org/0000-0003-4152-4081'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew J. Murphy', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052453109', 'display_name': 'Matthew A. Sleeman', 'orcid': 'https://orcid.org/0000-0003-2945-0315'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew A. Sleeman', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018894996', 'display_name': 'Jamie Orengo', 'orcid': 'https://orcid.org/0000-0002-2695-6508'}, 'institutions': [{'id': 'https://openalex.org/I186523950', 'display_name': 'Regeneron (United States)', 'ror': 'https://ror.org/02f51rf24', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I186523950']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jamie M. Orengo', 'raw_affiliation_strings': ['Regeneron Pharmaceuticals, Tarrytown, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Regeneron Pharmaceuticals, Tarrytown, NY, USA', 'institution_ids': ['https://openalex.org/I186523950']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5018894996'], 'corresponding_institution_ids': ['https://openalex.org/I186523950'], 'apc_list': {'value': 4900, 'currency': 'USD', 'value_usd': 4900, 'provenance': 'doaj'}, 'apc_paid': {'value': 4900, 'currency': 'USD', 'value_usd': 4900, 'provenance': 'doaj'}, 'fwci': 20.088, 'has_fulltext': False, 'cited_by_count': 301, 'citation_normalized_percentile': {'value': 0.99996, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '75', 'issue': '5', 'first_page': '1188', 'last_page': '1204'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12528', 'display_name': 'IL-33, ST2, and ILC Pathways', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10837', 'display_name': 'Dermatology and Skin Diseases', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dupilumab', 'display_name': 'Dupilumab', 'score': 0.82686573}, {'id': 'https://openalex.org/keywords/interleukin-13', 'display_name': 'Interleukin 13', 'score': 0.55934596}], 'concepts': [{'id': 'https://openalex.org/C2779824493', 'wikidata': 'https://www.wikidata.org/wiki/Q5315925', 'display_name': 'Dupilumab', 'level': 3, 'score': 0.82686573}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.76747465}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.636902}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5686413}, {'id': 'https://openalex.org/C32046619', 'wikidata': 'https://www.wikidata.org/wiki/Q14878303', 'display_name': 'Interleukin 13', 'level': 4, 'score': 0.55934596}, {'id': 'https://openalex.org/C2778166374', 'wikidata': 'https://www.wikidata.org/wiki/Q29938', 'display_name': 'House dust mite', 'level': 4, 'score': 0.5573456}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.541424}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.49911308}, {'id': 'https://openalex.org/C47348012', 'wikidata': 'https://www.wikidata.org/wiki/Q99486570', 'display_name': 'Interleukin 17', 'level': 3, 'score': 0.48878142}, {'id': 'https://openalex.org/C13373296', 'wikidata': 'https://www.wikidata.org/wiki/Q421866', 'display_name': 'Chemokine', 'level': 3, 'score': 0.4295002}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.42345756}, {'id': 'https://openalex.org/C141105273', 'wikidata': 'https://www.wikidata.org/wiki/Q79455', 'display_name': 'Immunoglobulin E', 'level': 3, 'score': 0.40965086}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.39672923}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.35938042}, {'id': 'https://openalex.org/C191732599', 'wikidata': 'https://www.wikidata.org/wiki/Q14865947', 'display_name': 'Interleukin 4', 'level': 3, 'score': 0.3407386}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.18153623}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.10898873}], 'mesh': [{'descriptor_ui': 'D018793', 'descriptor_name': 'Interleukin-13', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/all.14151', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14151', 'source': {'id': 'https://openalex.org/S68090385', 'display_name': 'Allergy', 'issn_l': '0105-4538', 'issn': ['0105-4538', '1398-9995'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7317958', 'pdf_url': 'https://europepmc.org/articles/pmc7317958?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317958', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31838750', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/all.14151', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14151', 'source': {'id': 'https://openalex.org/S68090385', 'display_name': 'Allergy', 'issn_l': '0105-4538', 'issn': ['0105-4538', '1398-9995'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.81}], 'grants': [{'funder': 'https://openalex.org/F4320307781', 'funder_display_name': 'Sanofi', 'award_id': None}, {'funder': 'https://openalex.org/F4320311600', 'funder_display_name': 'Regeneron Pharmaceuticals', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W1095614472', 'https://openalex.org/W1533977973', 'https://openalex.org/W1544230351', 'https://openalex.org/W1562441478', 'https://openalex.org/W1597248539', 'https://openalex.org/W1899691046', 'https://openalex.org/W1915358631', 'https://openalex.org/W1967215794', 'https://openalex.org/W1969912242', 'https://openalex.org/W1978128403', 'https://openalex.org/W1988899912', 'https://openalex.org/W1989245810', 'https://openalex.org/W1990562459', 'https://openalex.org/W1993738044', 'https://openalex.org/W2009342716', 'https://openalex.org/W2012868073', 'https://openalex.org/W2015681660', 'https://openalex.org/W2018303698', 'https://openalex.org/W2028190708', 'https://openalex.org/W2029903525', 'https://openalex.org/W2036075099', 'https://openalex.org/W2037123168', 'https://openalex.org/W2039930386', 'https://openalex.org/W2044798842', 'https://openalex.org/W2069654894', 'https://openalex.org/W2076678162', 'https://openalex.org/W2077332632', 'https://openalex.org/W2096234619', 'https://openalex.org/W2101401558', 'https://openalex.org/W2105521580', 'https://openalex.org/W2110052844', 'https://openalex.org/W2111608779', 'https://openalex.org/W2116364705', 'https://openalex.org/W2116583914', 'https://openalex.org/W2118630839', 'https://openalex.org/W2124566107', 'https://openalex.org/W2125805192', 'https://openalex.org/W2125986772', 'https://openalex.org/W2132430858', 'https://openalex.org/W2138355864', 'https://openalex.org/W2141317766', 'https://openalex.org/W2142495381', 'https://openalex.org/W2147450297', 'https://openalex.org/W2157278565', 'https://openalex.org/W2167829087', 'https://openalex.org/W2168938667', 'https://openalex.org/W2174132185', 'https://openalex.org/W2200308911', 'https://openalex.org/W2266684950', 'https://openalex.org/W2342693354', 'https://openalex.org/W2509074682', 'https://openalex.org/W2511120040', 'https://openalex.org/W2513258422', 'https://openalex.org/W2515900781', 'https://openalex.org/W2524051065', 'https://openalex.org/W2594033175', 'https://openalex.org/W2733058066', 'https://openalex.org/W2738574524', 'https://openalex.org/W2741189881', 'https://openalex.org/W2803404900', 'https://openalex.org/W2803941918', 'https://openalex.org/W2804085823', 'https://openalex.org/W2805002966', 'https://openalex.org/W2806098599', 'https://openalex.org/W2885240660', 'https://openalex.org/W2939247829', 'https://openalex.org/W2978440834', 'https://openalex.org/W2996174934', 'https://openalex.org/W4313335099', 'https://openalex.org/W642101920'], 'related_works': ['https://openalex.org/W4285992389', 'https://openalex.org/W3149930461', 'https://openalex.org/W3130265978', 'https://openalex.org/W3095741670', 'https://openalex.org/W3010711533', 'https://openalex.org/W3003385350', 'https://openalex.org/W2914649596', 'https://openalex.org/W2753360163', 'https://openalex.org/W2342791492', 'https://openalex.org/W2075472967'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'Dupilumab,': [2], 'a': [3, 49, 78, 144, 239], 'fully': [4], 'human': [5, 137], 'monoclonal': [6], 'antibody': [7], 'that': [8, 164, 204], 'binds': [9], 'IL‐4Rα': [10, 92], 'and': [11, 17, 30, 39, 55, 60, 66, 77, 119, 169, 220, 229], 'inhibits': [12], 'signaling': [13], 'of': [14, 35, 52, 58, 70, 81, 97, 126, 166, 225, 237], 'both': [15, 167], 'IL‐4': [16, 59, 88, 99, 154, 168, 219], 'IL‐13,': [18], 'has': [19], 'shown': [20], 'efficacy': [21], 'across': [22], 'multiple': [23, 244], 'diseases': [24], 'with': [25, 42], 'underlying': [26], 'type': [27, 63, 176, 226, 245], '2': [28, 64, 177, 227, 246], 'signatures': [29], 'is': [31, 171], 'approved': [32], 'for': [33], 'treatment': [34], 'asthma,': [36, 85], 'atopic': [37], 'dermatitis,': [38], 'chronic': [40], 'sinusitis': [41], 'nasal': [43], 'polyposis.': [44], 'We': [45, 129], 'sought': [46], 'to': [47, 158, 173, 181, 211], 'provide': [48, 231], 'comprehensive': [50], 'analysis': [51], 'the': [53, 234], 'redundant': [54, 124], 'distinct': [56], 'roles': [57], 'IL‐13': [61, 90, 101, 156, 170, 221], 'in': [62, 106, 138, 143, 150, 243], 'inflammation': [65, 228], 'report': [67], 'dupilumab': [68], 'mechanisms': [69], 'action.': [71], 'Methods': [72], 'Using': [73], 'primary': [74], 'cell': [75, 111], 'assays': [76], 'mouse': [79, 145], 'model': [80, 147], 'house': [82], 'dust': [83], 'mite–induced': [84], 'we': [86, 162], 'compared': [87], 'vs': [89, 91], 'blockers.': [93], 'Results': [94], 'Intranasal': [95], 'administration': [96], 'either': [98, 153], 'or': [100, 155], 'confers': [102], 'an': [103], 'asthma‐like': [104], 'phenotype': [105], 'mice': [107], 'by': [108, 148], 'inducing': [109], 'immune': [110], 'lung': [112, 185, 197], 'infiltration,': [113], 'including': [114], 'eosinophils,': [115, 202, 209], 'increasing': [116], 'cytokine/chemokine': [117], 'expression': [118], 'mucus': [120], 'production,': [121], 'thus': [122], 'demonstrating': [123, 203], 'functions': [125], 'these': [127, 216], 'cytokines.': [128], 'further': [130], 'teased': [131], 'out': [132], 'their': [133], 'respective': [134], 'contributions': [135], 'using': [136], 'vitro': [139], 'culture': [140], 'systems.': [141], 'Then,': [142], 'asthma': [146], 'comparing': [149], 'head‐to‐head': [151], 'studies,': [152], 'inhibition': [157], 'dual': [159, 190, 240], 'IL‐4/IL‐13': [160, 191, 241], 'inhibition,': [161], 'demonstrate': [163], 'blockade': [165, 192], 'required': [172], 'broadly': [174], 'block': [175], 'inflammation,': [178], 'which': [179], 'translates': [180], 'protection': [182], 'from': [183], 'allergen‐induced': [184], 'function': [186], 'impairment.': [187], 'Notably,': [188], 'only': [189], 'prevented': [193], 'eosinophil': [194], 'infiltration': [195], 'into': [196, 233], 'tissue': [198], 'without': [199], 'affecting': [200], 'circulating': [201, 208], 'tissue,': [205], 'but': [206], 'not': [207], 'contributes': [210], 'disease': [212], 'pathology.': [213], 'Conclusions': [214], 'Overall,': [215], 'data': [217], 'support': [218], 'as': [222], 'key': [223], 'drivers': [224], 'help': [230], 'insight': [232], 'therapeutic': [235], 'mechanism': [236], 'dupilumab,': [238], 'blocker,': [242], 'diseases.': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2996174934', 'counts_by_year': [{'year': 2024, 'cited_by_count': 99}, {'year': 2023, 'cited_by_count': 67}, {'year': 2022, 'cited_by_count': 73}, {'year': 2021, 'cited_by_count': 39}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2025-01-21T05:28:26.651741', 'created_date': '2019-12-26'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
