Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2753360163', 'doi': 'https://doi.org/10.2147/tcrm.s125964', 'title': 'Dupilumab in the management of moderate-to-severe asthma: the data so far', 'display_name': 'Dupilumab in the management of moderate-to-severe asthma: the data so far', 'publication_year': 2017, 'publication_date': '2017-09-01', 'ids': {'openalex': 'https://openalex.org/W2753360163', 'doi': 'https://doi.org/10.2147/tcrm.s125964', 'mag': '2753360163', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28979129', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5589101'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/tcrm.s125964', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=38240', 'source': {'id': 'https://openalex.org/S204453222', 'display_name': 'Therapeutics and Clinical Risk Management', 'issn_l': '1176-6336', 'issn': ['1176-6336', '1178-203X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=38240', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102930837', 'display_name': 'Pilar Barranco', 'orcid': 'https://orcid.org/0000-0002-4083-9930'}, 'institutions': [{'id': 'https://openalex.org/I4210103477', 'display_name': 'Hospital La Paz Institute for Health Research', 'ror': 'https://ror.org/017bynh47', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210103477']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Pilar Barranco', 'raw_affiliation_strings': ['Department of Allergy, Hospital La Paz institute for Health Research (idiPAZ), CiBeR de enfermedades Respiratorias (CiBeReS), Madrid, Spain;'], 'affiliations': [{'raw_affiliation_string': 'Department of Allergy, Hospital La Paz institute for Health Research (idiPAZ), CiBeR de enfermedades Respiratorias (CiBeReS), Madrid, Spain;', 'institution_ids': ['https://openalex.org/I4210103477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023173131', 'display_name': 'Elsa Phillips‐Anglés', 'orcid': 'https://orcid.org/0000-0002-9939-4163'}, 'institutions': [{'id': 'https://openalex.org/I4210103477', 'display_name': 'Hospital La Paz Institute for Health Research', 'ror': 'https://ror.org/017bynh47', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210103477']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Elsa Phillips-Angles', 'raw_affiliation_strings': ['Department of Allergy, Hospital La Paz institute for Health Research (idiPAZ), Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Allergy, Hospital La Paz institute for Health Research (idiPAZ), Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210103477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063540866', 'display_name': 'Javier Domínguez‐Ortega', 'orcid': 'https://orcid.org/0000-0002-5397-2327'}, 'institutions': [{'id': 'https://openalex.org/I4210103477', 'display_name': 'Hospital La Paz Institute for Health Research', 'ror': 'https://ror.org/017bynh47', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210103477']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Javier Dominguez-Ortega', 'raw_affiliation_strings': ['Department of Allergy, Hospital La Paz institute for Health Research (idiPAZ), CiBeR de enfermedades Respiratorias (CiBeReS), Madrid, Spain;'], 'affiliations': [{'raw_affiliation_string': 'Department of Allergy, Hospital La Paz institute for Health Research (idiPAZ), CiBeR de enfermedades Respiratorias (CiBeReS), Madrid, Spain;', 'institution_ids': ['https://openalex.org/I4210103477']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025399535', 'display_name': 'Santiago Quirce', 'orcid': 'https://orcid.org/0000-0001-8086-0921'}, 'institutions': [{'id': 'https://openalex.org/I4210103477', 'display_name': 'Hospital La Paz Institute for Health Research', 'ror': 'https://ror.org/017bynh47', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210103477']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Santiago Quirce', 'raw_affiliation_strings': ['Department of Allergy, Hospital La Paz institute for Health Research (idiPAZ), CiBeR de enfermedades Respiratorias (CiBeReS), Madrid, Spain;'], 'affiliations': [{'raw_affiliation_string': 'Department of Allergy, Hospital La Paz institute for Health Research (idiPAZ), CiBeR de enfermedades Respiratorias (CiBeReS), Madrid, Spain;', 'institution_ids': ['https://openalex.org/I4210103477']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5102930837'], 'corresponding_institution_ids': ['https://openalex.org/I4210103477'], 'apc_list': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'apc_paid': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'fwci': 0.792, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 38, 'citation_normalized_percentile': {'value': 0.388065, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': 'Volume 13', 'issue': None, 'first_page': '1139', 'last_page': '1149'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12528', 'display_name': 'IL-33, ST2, and ILC Pathways', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12538', 'display_name': 'Eosinophilic Esophagitis', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dupilumab', 'display_name': 'Dupilumab', 'score': 0.9581131}, {'id': 'https://openalex.org/keywords/interleukin-13', 'display_name': 'Interleukin 13', 'score': 0.5859325}, {'id': 'https://openalex.org/keywords/benralizumab', 'display_name': 'Benralizumab', 'score': 0.4845087}, {'id': 'https://openalex.org/keywords/pathophysiology-of-asthma', 'display_name': 'Pathophysiology of asthma', 'score': 0.4273106}], 'concepts': [{'id': 'https://openalex.org/C2779824493', 'wikidata': 'https://www.wikidata.org/wiki/Q5315925', 'display_name': 'Dupilumab', 'level': 3, 'score': 0.9581131}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.91984963}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.8063054}, {'id': 'https://openalex.org/C32046619', 'wikidata': 'https://www.wikidata.org/wiki/Q14878303', 'display_name': 'Interleukin 13', 'level': 4, 'score': 0.5859325}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.556863}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.552456}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.54703283}, {'id': 'https://openalex.org/C2779185760', 'wikidata': 'https://www.wikidata.org/wiki/Q3638304', 'display_name': 'Benralizumab', 'level': 5, 'score': 0.4845087}, {'id': 'https://openalex.org/C2779999680', 'wikidata': 'https://www.wikidata.org/wiki/Q17157254', 'display_name': 'Pathophysiology of asthma', 'level': 3, 'score': 0.4273106}, {'id': 'https://openalex.org/C2777832160', 'wikidata': 'https://www.wikidata.org/wiki/Q3306175', 'display_name': 'Mepolizumab', 'level': 4, 'score': 0.4149549}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.360402}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.33618698}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.29715854}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.24485502}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.19295171}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.10068026}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/tcrm.s125964', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=38240', 'source': {'id': 'https://openalex.org/S204453222', 'display_name': 'Therapeutics and Clinical Risk Management', 'issn_l': '1176-6336', 'issn': ['1176-6336', '1178-203X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5589101', 'pdf_url': 'https://europepmc.org/articles/pmc5589101?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://repositoriosaludmadrid.es/handle/20.500.12530/30202', 'pdf_url': 'https://repositoriosaludmadrid.es//bitstream/20.500.12530/30202/1/PMC5589101.pdf', 'source': {'id': 'https://openalex.org/S4306402641', 'display_name': 'LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4383465926', 'host_organization_name': 'LA Referencia', 'host_organization_lineage': ['https://openalex.org/I4383465926'], 'host_organization_lineage_names': ['LA Referencia'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589101', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28979129', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/tcrm.s125964', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=38240', 'source': {'id': 'https://openalex.org/S204453222', 'display_name': 'Therapeutics and Clinical Risk Management', 'issn_l': '1176-6336', 'issn': ['1176-6336', '1178-203X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1502387407', 'https://openalex.org/W1506450640', 'https://openalex.org/W1564761922', 'https://openalex.org/W1570067081', 'https://openalex.org/W1596331316', 'https://openalex.org/W1947221834', 'https://openalex.org/W1968570108', 'https://openalex.org/W1990725947', 'https://openalex.org/W1995908153', 'https://openalex.org/W2021701428', 'https://openalex.org/W2021852404', 'https://openalex.org/W2022877219', 'https://openalex.org/W2026028987', 'https://openalex.org/W2032110591', 'https://openalex.org/W2036075099', 'https://openalex.org/W2038556027', 'https://openalex.org/W2043046650', 'https://openalex.org/W2043659106', 'https://openalex.org/W2043943442', 'https://openalex.org/W2050237494', 'https://openalex.org/W2060763719', 'https://openalex.org/W2063801679', 'https://openalex.org/W2065844939', 'https://openalex.org/W2069353968', 'https://openalex.org/W2072815966', 'https://openalex.org/W2080317016', 'https://openalex.org/W2085632101', 'https://openalex.org/W2086782209', 'https://openalex.org/W2087055962', 'https://openalex.org/W2098082628', 'https://openalex.org/W2098276532', 'https://openalex.org/W2100578775', 'https://openalex.org/W2107207387', 'https://openalex.org/W2118630839', 'https://openalex.org/W2119706375', 'https://openalex.org/W2122027002', 'https://openalex.org/W2127482775', 'https://openalex.org/W2128472414', 'https://openalex.org/W2138415167', 'https://openalex.org/W2142940006', 'https://openalex.org/W2149810044', 'https://openalex.org/W2152590429', 'https://openalex.org/W2153395214', 'https://openalex.org/W2157566717', 'https://openalex.org/W2160847340', 'https://openalex.org/W2167829087', 'https://openalex.org/W2168596771', 'https://openalex.org/W2171449633', 'https://openalex.org/W2174132185', 'https://openalex.org/W2266684950', 'https://openalex.org/W2275518515', 'https://openalex.org/W2342693354', 'https://openalex.org/W2343444323', 'https://openalex.org/W2401164099', 'https://openalex.org/W2480571942', 'https://openalex.org/W2515900781', 'https://openalex.org/W2601652410', 'https://openalex.org/W2766726816', 'https://openalex.org/W2916904419', 'https://openalex.org/W4236078293'], 'related_works': ['https://openalex.org/W4293147719', 'https://openalex.org/W4210632018', 'https://openalex.org/W3212805450', 'https://openalex.org/W3176692335', 'https://openalex.org/W3142314375', 'https://openalex.org/W3131664678', 'https://openalex.org/W3120641611', 'https://openalex.org/W3106546299', 'https://openalex.org/W3089109464', 'https://openalex.org/W2799775149'], 'abstract_inverted_index': {'Abstract:': [0], 'Severe': [1], 'asthma': [2, 58, 65, 203], 'constitutes': [3], 'illness': [4], 'in': [5, 67, 105, 183, 204], 'a': [6, 18, 33, 53, 180, 197], 'relatively': [7], 'small': [8], 'proportion': [9], 'of': [10, 41, 50, 56, 70, 74, 79, 90, 108, 115, 119, 159, 186], 'all': [11], 'patients': [12, 71], 'with': [13, 24], 'asthma,': [14, 187, 210], 'but': [15], 'it': [16], 'is': [17, 102, 112, 148], 'major': [19], 'public': [20], 'health': [21, 37], 'problem': [22], '–': [23, 94], 'considerable': [25], 'effect': [26], 'on': [27, 36, 169, 189], 'morbidity,': [28], 'mortality,': [29], 'as': [30, 32, 126, 173, 196], 'well': [31], 'high': [34], 'burden': [35], 'care': [38], 'resources.': [39], 'Regardless': [40], 'effective': [42], 'treatments': [43], 'being': [44], 'widely': [45], 'available': [46], 'and': [47, 63, 129, 134, 162, 171, 188], 'the': [48, 88, 116, 132, 139, 145, 156, 184, 205], 'existence': [49], 'treatment': [51, 199, 215], 'guidelines,': [52], 'large': [54], 'population': [55, 85], 'severe': [57, 202], 'cases': [59], 'remain': [60], 'uncontrolled.': [61], 'Achieving': [62], 'maintaining': [64], 'control': [66], 'this': [68, 84, 165], 'group': [69], 'is,': [72], 'therefore,': [73], 'utmost': [75], 'importance.': [76], 'The': [77], 'recognition': [78], 'distinct': [80], 'inflammatory': [81, 136], 'phenotypes': [82], 'within': [83], 'has': [86], 'driven': [87], 'development': [89], 'targeted': [91, 97], 'biological': [92, 157], 'therapies': [93], 'particularly,': [95], 'selective': [96], 'monoclonal': [98, 213], 'antibodies': [99], '(mAbs).': [100], 'It': [101], 'noteworthy': [103], 'that': [104], 'approximately': [106], '50%': [107], 'these': [109, 174], 'patients,': [110], 'there': [111], 'strong': [113], 'evidence': [114], 'pathogenic': [117], 'role': [118, 182], 'T': [120], 'helper': [121], 'type-2': [122], '(Th2)': [123], 'cytokines,': [124], 'such': [125], 'interleukin': [127], '(IL)-4': [128], 'IL-13,': [130, 172], 'orchestrating': [131], 'eosinophilic': [133], 'allergic': [135], 'processes.': [137], 'Among': [138], 'recently': [140], 'developed': [141], 'antiasthma': [142], 'biologic': [143], 'drugs,': [144], 'mAb': [146], 'dupilumab': [147], 'very': [149], 'promising': [150], 'given': [151], 'its': [152], 'ability': [153], 'to': [154, 178], 'inhibit': [155], 'effects': [158], 'both': [160], 'IL-4': [161, 170], 'IL-13.': [163], 'In': [164], 'review,': [166], 'we': [167], 'focused': [168], 'interleukins': [175], 'are': [176], 'considered': [177], 'play': [179], 'key': [181], 'pathophysiology': [185], 'dupilumab,': [190, 209], 'an': [191], 'anti-IL-4': [192], 'receptor': [193], 'human': [194], 'mAb,': [195], 'forthcoming': [198], 'for': [200], 'uncontrolled': [201], 'near': [206], 'future.': [207], 'Keywords:': [208], 'interleukin-4,': [211], 'interleukin-13,': [212], 'antibodies,': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2753360163', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 9}], 'updated_date': '2025-01-05T09:09:47.045720', 'created_date': '2017-09-15'}