Dupilumab to Treat Type 2 Inflammatory Diseases in Children and Adolescents

Name: Work Video:
Duration: 3 min 30 s
Amelia Licari; Riccardo Castagnoli; Alessia Marseglia; Francesca Olivero; Martina Votto; Giorgio Ciprandi; Gian Luigi Marseglia
{'id': 'https://openalex.org/W3010711533', 'doi': 'https://doi.org/10.1007/s40272-020-00387-2', 'title': 'Dupilumab to Treat Type 2 Inflammatory Diseases in Children and Adolescents', 'display_name': 'Dupilumab to Treat Type 2 Inflammatory Diseases in Children and Adolescents', 'publication_year': 2020, 'publication_date': '2020-03-11', 'ids': {'openalex': 'https://openalex.org/W3010711533', 'doi': 'https://doi.org/10.1007/s40272-020-00387-2', 'mag': '3010711533', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32157553'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s40272-020-00387-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S84493273', 'display_name': 'Pediatric Drugs', 'issn_l': '1174-5878', 'issn': ['1174-5878', '1179-2019'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035021264', 'display_name': 'Amelia Licari', 'orcid': 'https://orcid.org/0000-0002-1773-6482'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Amelia Licari', 'raw_affiliation_strings': ['Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049486770', 'display_name': 'Riccardo Castagnoli', 'orcid': 'https://orcid.org/0000-0003-0029-9383'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Riccardo Castagnoli', 'raw_affiliation_strings': ['Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107834241', 'display_name': 'Alessia Marseglia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alessia Marseglia', 'raw_affiliation_strings': ['Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030076197', 'display_name': 'Francesca Olivero', 'orcid': 'https://orcid.org/0000-0002-9363-455X'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Olivero', 'raw_affiliation_strings': ['Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024251167', 'display_name': 'Martina Votto', 'orcid': 'https://orcid.org/0000-0002-4271-8649'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Martina Votto', 'raw_affiliation_strings': ['Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047558679', 'display_name': 'Giorgio Ciprandi', 'orcid': 'https://orcid.org/0000-0001-7016-8421'}, 'institutions': [{'id': 'https://openalex.org/I4210116121', 'display_name': 'Casa di Cura Columbus', 'ror': 'https://ror.org/023xsn018', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116121']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giorgio Ciprandi', 'raw_affiliation_strings': ['Allergy Clinic, Casa di Cura Villa Montallegro, Genova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Allergy Clinic, Casa di Cura Villa Montallegro, Genova, Italy', 'institution_ids': ['https://openalex.org/I4210116121']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055022644', 'display_name': 'Gian Luigi Marseglia', 'orcid': 'https://orcid.org/0000-0003-3662-0159'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gian Luigi Marseglia', 'raw_affiliation_strings': ['Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, viale Golgi 19, 27100, Pavia, Italy', 'institution_ids': ['https://openalex.org/I25217355']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5035021264'], 'corresponding_institution_ids': ['https://openalex.org/I25217355'], 'apc_list': {'value': 3390, 'currency': 'EUR', 'value_usd': 4390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.676, 'has_fulltext': False, 'cited_by_count': 66, 'citation_normalized_percentile': {'value': 0.999768, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '22', 'issue': '3', 'first_page': '295', 'last_page': '310'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12538', 'display_name': 'Eosinophilic Esophagitis', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12538', 'display_name': 'Eosinophilic Esophagitis', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12528', 'display_name': 'IL-33, ST2, and ILC Pathways', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dupilumab', 'display_name': 'Dupilumab', 'score': 0.9729371}, {'id': 'https://openalex.org/keywords/eosinophilic-esophagitis', 'display_name': 'Eosinophilic Esophagitis', 'score': 0.5978546}, {'id': 'https://openalex.org/keywords/interleukin-13', 'display_name': 'Interleukin 13', 'score': 0.5292382}, {'id': 'https://openalex.org/keywords/nasal-polyps', 'display_name': 'Nasal Polyps', 'score': 0.48669913}, {'id': 'https://openalex.org/keywords/omalizumab', 'display_name': 'Omalizumab', 'score': 0.45152253}], 'concepts': [{'id': 'https://openalex.org/C2779824493', 'wikidata': 'https://www.wikidata.org/wiki/Q5315925', 'display_name': 'Dupilumab', 'level': 3, 'score': 0.9729371}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8471507}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.655656}, {'id': 'https://openalex.org/C2778329239', 'wikidata': 'https://www.wikidata.org/wiki/Q268667', 'display_name': 'Atopic dermatitis', 'level': 2, 'score': 0.6186562}, {'id': 'https://openalex.org/C2781065132', 'wikidata': 'https://www.wikidata.org/wiki/Q2057356', 'display_name': 'Eosinophilic esophagitis', 'level': 3, 'score': 0.5978546}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.5540772}, {'id': 'https://openalex.org/C32046619', 'wikidata': 'https://www.wikidata.org/wiki/Q14878303', 'display_name': 'Interleukin 13', 'level': 4, 'score': 0.5292382}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.52321887}, {'id': 'https://openalex.org/C141105273', 'wikidata': 'https://www.wikidata.org/wiki/Q79455', 'display_name': 'Immunoglobulin E', 'level': 3, 'score': 0.49912357}, {'id': 'https://openalex.org/C2781390199', 'wikidata': 'https://www.wikidata.org/wiki/Q8055111', 'display_name': 'Nasal polyps', 'level': 2, 'score': 0.48669913}, {'id': 'https://openalex.org/C2777832160', 'wikidata': 'https://www.wikidata.org/wiki/Q3306175', 'display_name': 'Mepolizumab', 'level': 4, 'score': 0.45770976}, {'id': 'https://openalex.org/C2778564945', 'wikidata': 'https://www.wikidata.org/wiki/Q415392', 'display_name': 'Omalizumab', 'level': 4, 'score': 0.45152253}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.33203435}, {'id': 'https://openalex.org/C16005928', 'wikidata': 'https://www.wikidata.org/wiki/Q171171', 'display_name': 'Dermatology', 'level': 1, 'score': 0.33188608}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.2616573}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.23833564}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.23822156}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.20943055}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12326953}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D003876', 'descriptor_name': 'Dermatitis, Atopic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D065631', 'descriptor_name': 'Rhinitis, Allergic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002908', 'descriptor_name': 'Chronic Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003876', 'descriptor_name': 'Dermatitis, Atopic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065631', 'descriptor_name': 'Rhinitis, Allergic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s40272-020-00387-2', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S84493273', 'display_name': 'Pediatric Drugs', 'issn_l': '1174-5878', 'issn': ['1174-5878', '1179-2019'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320330', 'host_organization_name': 'Adis, Springer Healthcare', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320330'], 'host_organization_lineage_names': ['Springer Nature', 'Adis, Springer Healthcare'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32157553', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1587742067', 'https://openalex.org/W1993355778', 'https://openalex.org/W2007565796', 'https://openalex.org/W2013398275', 'https://openalex.org/W2026028987', 'https://openalex.org/W2030222836', 'https://openalex.org/W2043046650', 'https://openalex.org/W2058856567', 'https://openalex.org/W2065894458', 'https://openalex.org/W2073476576', 'https://openalex.org/W2075871915', 'https://openalex.org/W2085094484', 'https://openalex.org/W2118630839', 'https://openalex.org/W2124222608', 'https://openalex.org/W2144120552', 'https://openalex.org/W2162677614', 'https://openalex.org/W2168900215', 'https://openalex.org/W2200308911', 'https://openalex.org/W2266684950', 'https://openalex.org/W2267379549', 'https://openalex.org/W2483681232', 'https://openalex.org/W2524051065', 'https://openalex.org/W2534854440', 'https://openalex.org/W2594033175', 'https://openalex.org/W2610814011', 'https://openalex.org/W2681102259', 'https://openalex.org/W2730614382', 'https://openalex.org/W2734059082', 'https://openalex.org/W2755710368', 'https://openalex.org/W2756691552', 'https://openalex.org/W2770868505', 'https://openalex.org/W2771011851', 'https://openalex.org/W2782736912', 'https://openalex.org/W2786732206', 'https://openalex.org/W2800511527', 'https://openalex.org/W2801759342', 'https://openalex.org/W2803941918', 'https://openalex.org/W2805002966', 'https://openalex.org/W2885859025', 'https://openalex.org/W2887053600', 'https://openalex.org/W2895519166', 'https://openalex.org/W2903336629', 'https://openalex.org/W2907876292', 'https://openalex.org/W2916087813', 'https://openalex.org/W2917101705', 'https://openalex.org/W2921132618', 'https://openalex.org/W2940853643', 'https://openalex.org/W2957823552', 'https://openalex.org/W2964096374', 'https://openalex.org/W2968987915', 'https://openalex.org/W2973122049', 'https://openalex.org/W2973437633', 'https://openalex.org/W2978440834', 'https://openalex.org/W2979884851', 'https://openalex.org/W2980196021', 'https://openalex.org/W2981359819', 'https://openalex.org/W2981554886', 'https://openalex.org/W2981677156', 'https://openalex.org/W2988092601', 'https://openalex.org/W2989878367', 'https://openalex.org/W2995377367', 'https://openalex.org/W3108650042'], 'related_works': ['https://openalex.org/W4387182278', 'https://openalex.org/W4385477611', 'https://openalex.org/W4318574464', 'https://openalex.org/W4309047244', 'https://openalex.org/W4237501114', 'https://openalex.org/W3089147949', 'https://openalex.org/W3088120911', 'https://openalex.org/W2982816949', 'https://openalex.org/W2906520818', 'https://openalex.org/W2765547195'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3010711533', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 13}], 'updated_date': '2024-12-31T09:20:12.685807', 'created_date': '2020-03-23'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
