Title: Phamacokinetic of Hainan Daphniphullum calucinum Benth in Rats.
Abstract: Objective To studythepharmacokineticcharacteristicof quercetininrat after oral administration of Daphniphullum calucinum Benth extract.Methods The concentrations of quercetin in rats were determined by LC-MS/MS after drug administration and the pharmacokinetic parameters of quercetin were estimated by DAS2.0 computer program.Result The pharmacokinetic parameters were as follows:Tmax =(0.195 ±0.155) h,Cmax =(35.00 ± 15.30) ng/ml,AUC0-t =(66.82 ±21.77) ng/(ml·h),t1/2 =(5.736 ± 2.513) h.Conclusion The method was proved to be specific,sensitive,and suitable for the pharmacokinetic study of quercetin in traditional Chinese medicines and its preparations.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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