Title: Study on absolute bioavailability of nuciferine in Rats
Abstract: Objective To investigate the pharmacokinetic characteristics of nuciferine and its absolute bioavailability in rats.Methods I.v.(5 mg·kg-1) and p.o.(20 mg·kg-1) administration were given to SD rats respectively,and the plasma concentration of nuciferine in rats was determined by LC-MS/MS.Results The main pharmacokinetic parameters through i.v.and p.o.were as followed: respectively,AUC(0-∞)(1 118.24±420.90) and(3 111.34±1986.29) ng·h·mL-1,Cmax(1 213.17±359.29) and(1 257.50±942.37) ng·mL-1;t1/2(1.30±0.69) and(4.89±2.88) h.tmax was(0.33±0.18) h via p.o..The absolute bioavailability was 69.56% after dosage correction.Conclusion This method is specific and sensitive,suitable for in vitro determination of nuciferine.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 1
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