Title: Pharmacokinetics Study of Azithromycin Tablets in Health Volunteers by HPLC-MS/MS
Abstract: OBJECTIVE To establish HPLC-MS/MS method for the determination of azithromycin in human serum,study pharmacokinetics of azithromycin in healthy volunteers.METHODS azithromycin in serum were determined by LC-MS/MS and the pharmacokinetic parameters were calculated by PKs program.RESULTS The linear regressive curves were obtainedinthe range of 3.33 ~833μg.L-1.Re-coveries usingthe method of azithromycin was 100 %~115 %.The within-day and betweenday RSDs were lessthan 6 %.After oral adminationof azithromycintablets in 18 healthy volunteers,the pharmacokinetive process was fittedtothe two-compartment mode,the main pharmacoki-netics parameters were :t1/2α(2.93±3.38)h,t1/2β(36.24±8.34)h,t1/2ka(0.61±0.34)h,ρmax(415.9±114.4)ng.mL-1,tmax(1.812±0.650)h,AUC0-t(6937±1626) μg.h.mL-1,CL/ F(0.076±0.0182) L.h-1,Vd/ F(3.976±1.413) L,tlag(0.349±0.173)h,k10(0.110±0.039)h-1,k21(0.067±0.025)h-1andk12(0.223±0.109)h-1.CONCLUSION HPLC-MS/MS method established in thisstudyis simple,sensitive with good accuracy and precision,which can be adaptedto pharmacokinetics study.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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