Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2941115030', 'doi': 'https://doi.org/10.1097/01.ju.0000555589.51523.f5', 'title': 'MP22-05 AKR1C3 PROMOTES AR-V7 PROTEIN STABILIZATION AND CONFERS ANTI-ANDROGEN RESISTANCE IN ADVANCED PROSTATE CANCER', 'display_name': 'MP22-05 AKR1C3 PROMOTES AR-V7 PROTEIN STABILIZATION AND CONFERS ANTI-ANDROGEN RESISTANCE IN ADVANCED PROSTATE CANCER', 'publication_year': 2019, 'publication_date': '2019-04-01', 'ids': {'openalex': 'https://openalex.org/W2941115030', 'doi': 'https://doi.org/10.1097/01.ju.0000555589.51523.f5', 'mag': '2941115030'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.ju.0000555589.51523.f5', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000555589.51523.f5', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000555589.51523.f5', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103846264', 'display_name': 'Chengfei Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chengfei Liu*', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086066594', 'display_name': 'Joy C. Yang', 'orcid': 'https://orcid.org/0000-0001-9162-481X'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joy C. Yang', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012734277', 'display_name': 'Wei Lou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Lou', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074725449', 'display_name': 'Liangren Liu', 'orcid': 'https://orcid.org/0000-0001-9748-4088'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Liangren Liu', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088621070', 'display_name': 'Christopher P. Evans', 'orcid': 'https://orcid.org/0000-0001-5626-8901'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher P. Evans', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048369552', 'display_name': 'Allen C. Gao', 'orcid': 'https://orcid.org/0000-0002-5966-9038'}, 'institutions': [{'id': 'https://openalex.org/I43522216', 'display_name': 'California State University, Sacramento', 'ror': 'https://ror.org/03e26wv14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I43522216']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Allen C. Gao', 'raw_affiliation_strings': ['Sacramento, CA'], 'affiliations': [{'raw_affiliation_string': 'Sacramento, CA', 'institution_ids': ['https://openalex.org/I43522216']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '201', 'issue': 'Supplement 4', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12533', 'display_name': 'Aldose Reductase and Taurine', 'score': 0.9309, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.74354535}], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8488068}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.7506279}, {'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.74354535}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5884963}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.58001363}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.562058}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.5414214}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5183764}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.5021374}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.47382864}, {'id': 'https://openalex.org/C190232843', 'wikidata': 'https://www.wikidata.org/wiki/Q1950808', 'display_name': 'Small hairpin RNA', 'level': 4, 'score': 0.41882366}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3712123}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.34990472}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.27105194}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.21243206}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.16854626}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.1628837}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10603541}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07041547}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.ju.0000555589.51523.f5', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000555589.51523.f5', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.ju.0000555589.51523.f5', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000555589.51523.f5', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4362621709', 'https://openalex.org/W4362609326', 'https://openalex.org/W4362609250', 'https://openalex.org/W4362495275', 'https://openalex.org/W4362495086', 'https://openalex.org/W4361940014', 'https://openalex.org/W4361890616', 'https://openalex.org/W2890810587', 'https://openalex.org/W2767048879', 'https://openalex.org/W2737056430'], 'abstract_inverted_index': {'You': [0], 'have': [1], 'accessJournal': [2], 'of': [3, 121, 161, 207, 216, 224, 243, 306, 349, 401, 420, 424], 'UrologyProstate': [4], 'Cancer:': [5], 'Advanced': [6], '(including': [7], 'Drug': [8], 'Therapy)': [9], 'II': [10], '(MP22)1': [11], 'Apr': [12], '2019MP22-05': [13], 'AKR1C3': [14, 138, 152, 170, 208, 217, 225, 230, 244, 257, 273, 288, 350, 355, 369], 'PROMOTES': [15], 'AR-V7': [16, 140, 154, 172, 232, 262, 265, 352, 366, 371, 375], 'PROTEIN': [17], 'STABILIZATION': [18], 'AND': [19, 116], 'CONFERS': [20], 'ANTI-ANDROGEN': [21], 'RESISTANCE': [22], 'IN': [23], 'ADVANCED': [24], 'PROSTATE': [25], 'CANCER': [26], 'Chengfei': [27, 43, 477], 'Liu*,': [28], 'Joy': [29, 52, 484], 'C.': [30, 41, 53, 55, 94, 96, 485, 515], 'Yang,': [31], 'Wei': [32, 63, 492], 'Lou,': [33], 'Liangren': [34, 72, 499], 'Liu,': [35], 'Christopher': [36, 81, 506], 'P.': [37, 82, 84, 507], 'Evans,': [38], 'and': [39, 92, 139, 146, 149, 171, 173, 210, 231, 238, 253, 263, 294, 321, 326, 334, 344, 351, 361, 373, 387, 394, 416, 433, 454, 473], 'Allen': [40, 93, 514], 'Gao': [42, 97, 516], 'Liu*Chengfei': [44], 'Liu*': [45, 478], 'More': [46, 57, 66, 75, 86, 98, 479, 487, 494, 501, 509, 517], 'articles': [47, 58, 67, 76, 87, 99, 480, 488, 495, 502, 510, 518], 'by': [48, 59, 68, 77, 88, 100, 188, 200, 214, 228, 236, 274, 409, 434, 449, 468, 481, 489, 496, 503, 511, 519], 'this': [49, 60, 69, 78, 89, 101, 157, 162, 482, 490, 497, 504, 512, 520], 'author': [50, 61, 70, 79, 90, 102, 483, 491, 498, 505, 513, 521], ',': [51, 62, 71, 80, 91], 'YangJoy': [54], 'Yang': [56, 486], 'LouWei': [64], 'Lou': [65, 493], 'LiuLiangren': [73], 'Liu': [74, 500], 'EvansChristopher': [83], 'Evans': [85, 508], 'GaoAllen': [95], 'View': [103], 'All': [104, 523], 'Author': [105], 'Informationhttps://doi.org/10.1097/01.JU.0000555589.51523.f5AboutPDF': [106], 'ToolsAdd': [107], 'to': [108, 165, 342, 359, 392], 'favoritesDownload': [109], 'CitationsTrack': [110], 'CitationsPermissionsReprints': [111], 'ShareFacebookLinked': [112], 'InTwitterEmail': [113], 'Abstract': [114], 'INTRODUCTION': [115], 'OBJECTIVES:': [117], 'The': [118, 159, 205, 241], 'resistant': [119, 127, 300, 309, 341, 357, 378, 391], 'mechanisms': [120], 'next': [122], 'generation': [123], 'anti-androgens': [124], 'in': [125, 144, 178, 195, 251, 254, 298, 377, 407], 'castration': [126], 'prostate': [128, 301, 336], 'cancer': [129, 337], 'are': [130, 339, 389], 'incompletely': [131], 'understood.': [132], 'Our': [133], 'previous': [134], 'work': [135, 404], 'demonstrated': [136], 'that': [137, 150, 312, 332], 'play': [141], 'important': [142], 'roles': [143, 177], 'enzalutamide': [145, 299, 333, 393], 'abiraterone': [147, 335, 395], 'resistance,': [148], 'targeting': [151], 'or': [153, 222], 'could': [155], 'overcome': [156], 'resistance.': [158, 180], 'aim': [160], 'study': [163], 'is': [164], 'investigate': [166], 'the': [167, 282, 365, 381, 417, 437], 'interaction': [168, 233], 'between': [169], 'determine': [174], 'their': [175], 'coordinated': [176], 'drug': [179], 'METHODS:': [181], 'Global': [182], 'gene': [183], 'expression': [184, 209, 218, 280], 'analysis': [185, 305], 'was': [186, 198, 405], 'analyzed': [187, 199], 'microarray': [189], 'analysis.': [190], 'Steroid': [191], 'profile': [192], 'including': [193], 'androgens': [194], 'tumor': [196], 'tissues': [197], 'Liquid': [201], 'Chromatography-Mass': [202], 'Spectrometry': [203], '(LC-MS).': [204], 'effects': [206, 242], 'activation': [211, 245, 348], 'were': [212, 234, 249], 'examined': [213, 250], 'knockdown': [215], 'using': [219], 'lentiviral': [220], 'shRNA': [221], 'inhibition': [223], 'enzymatic': [226], 'activity': [227], 'indomethacin.': [229], 'determined': [235], 'co-immunoprecipitation': [237], 'dual': [239], 'immunofluorescence.': [240], 'on': [246], 'anti-androgen': [247], 'sensitivity': [248], 'vitro': [252], 'vivo.': [255], 'RESULTS:': [256], 'forms': [258], 'a': [259], 'complex': [260, 398], 'with': [261], 'induces': [264, 370], 'overexpression': [266, 372], 'through': [267, 281, 347, 364, 380], 'increasing': [268], 'its': [269], 'protein': [270, 279, 317, 376], 'stabilization.': [271], 'Targeting': [272, 354], 'indomethacin': [275, 307, 313], 'significantly': [276, 314], 'decreases': [277], 'AR/AR-V7': [278, 327], 'ubiquitin': [283, 382], 'mediated': [284], 'proteasome': [285, 383], 'pathway': [286, 293, 320], 'activation.': [287], 'activates': [289, 315], 'steroid': [290], 'hormone': [291], 'biosynthesis': [292], 'reprograms': [295], 'AR': [296], 'signaling': [297], 'cancer.': [302], 'Additionally,': [303], 'bioinformatic': [304], 'treated': [308], 'cells': [310, 338, 358, 379], 'discovered': [311], 'unfolded': [316], 'response': [318], '(UPR)': [319], 'suppresses': [322], 'Myc,': [323], 'cell': [324], 'cycle': [325], 'pathways.': [328, 353], 'Finally,': [329], 'we': [330], 'found': [331], 'cross': [340, 390], 'apalutamide': [343, 360], 'darolutamide,': [345], 'possibly': [346], 're-sensitizes': [356], 'darolutamide': [362, 388], 'treatment': [363], 'inhibition.': [367], 'CONCLUSIONS:': [368], 'stabilizes': [374], 'system': [384], 'alteration.': [385], 'Apalutamide': [386], 'via': [396], 'AKR1C3/AR-V7': [397], 'regulation.': [399], 'Source': [400], 'Funding:': [402], 'This': [403], 'supported': [406], 'part': [408], 'grants': [410], 'NIH/NCI': [411], 'CA168601,': [412], 'CA179970,': [413], 'DOD': [414], 'PC150229,': [415], 'U.S.': [418], 'Department': [419], 'Veterans': [421], 'Affairs,': [422], 'Office': [423], 'Research': [425], '&': [426, 465], 'Development': [427], 'BL&D': [428], 'grant': [429], 'number': [430], 'I01BX0002653': [431], '(A.C.G.)': [432], 'resources': [435], 'from': [436], 'VA': [438], 'Northern': [439], 'California': [440], 'Health': [441], 'Care': [442], 'System,': [443], 'Sacramento,': [444, 446], 'California.': [445], 'CA©': [447], '2019': [448, 467], 'American': [450, 469], 'Urological': [451, 470], 'Association': [452, 471], 'Education': [453, 472], 'Research,': [455, 474], 'Inc.FiguresReferencesRelatedDetails': [456], 'Volume': [457], '201Issue': [458], 'Supplement': [459], '4April': [460], '2019Page:': [461], 'e318-e318': [462], 'Advertisement': [463, 524], 'Copyright': [464], 'Permissions©': [466], 'Inc.MetricsAuthor': [475], 'Information': [476], 'Expand': [522], 'PDF': [525], 'downloadLoading': [526], '...': [527]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2941115030', 'counts_by_year': [], 'updated_date': '2024-12-24T08:11:32.226527', 'created_date': '2019-05-03'}