Publication Information

{'id': 'https://openalex.org/W2737056430', 'doi': 'https://doi.org/10.1158/1535-7163.mct-17-0030', 'title': 'Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells', 'display_name': 'Quercetin Targets hnRNPA1 to Overcome Enzalutamide Resistance in Prostate Cancer Cells', 'publication_year': 2017, 'publication_date': '2017-07-21', 'ids': {'openalex': 'https://openalex.org/W2737056430', 'doi': 'https://doi.org/10.1158/1535-7163.mct-17-0030', 'mag': '2737056430', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28729398', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5716891'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-17-0030', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/16/12/2770.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://mct.aacrjournals.org/content/molcanther/16/12/2770.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070783001', 'display_name': 'Ramakumar Tummala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ramakumar Tummala', 'raw_affiliation_strings': ['Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California.', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012734277', 'display_name': 'Wei Lou', 'orcid': 'https://orcid.org/0000-0002-4688-1216'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Lou', 'raw_affiliation_strings': ['Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California.', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048369552', 'display_name': 'Allen C. Gao', 'orcid': 'https://orcid.org/0000-0002-5966-9038'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Allen C. Gao', 'raw_affiliation_strings': ['Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California.', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070199787', 'display_name': 'Nagalakshmi Nadiminty', 'orcid': 'https://orcid.org/0000-0003-3408-3206'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Nagalakshmi Nadiminty', 'raw_affiliation_strings': ['Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California.'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Comprehensive Cancer Center, University of California Davis, Sacramento, California.', 'institution_ids': ['https://openalex.org/I84218800']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5070199787'], 'corresponding_institution_ids': ['https://openalex.org/I84218800'], 'apc_list': None, 'apc_paid': None, 'fwci': 9.435, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 94, 'citation_normalized_percentile': {'value': 0.999972, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '16', 'issue': '12', 'first_page': '2770', 'last_page': '2779'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.99, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.99462354}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.99462354}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.88868487}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.88540274}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6305927}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.4853603}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.45405442}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44440442}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38863415}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3808689}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3567285}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34299606}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.30462074}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.059330493}], 'mesh': [], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-17-0030', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/16/12/2770.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5716891', 'pdf_url': 'https://europepmc.org/articles/pmc5716891?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716891', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.22503970', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S1_from_Quercetin_Targets_hnRNPA1_to_Overcome_Enzalutamide_Resistance_in_Prostate_Cancer_Cells/22503970/1/files/39963427.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.22503967', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S2_from_Quercetin_Targets_hnRNPA1_to_Overcome_Enzalutamide_Resistance_in_Prostate_Cancer_Cells/22503967/1/files/39963424.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.22503961', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S3_from_Quercetin_Targets_hnRNPA1_to_Overcome_Enzalutamide_Resistance_in_Prostate_Cancer_Cells/22503961/1/files/39963418.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-17-0030', 'pdf_url': 'https://mct.aacrjournals.org/content/molcanther/16/12/2770.full.pdf', 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.83}], 'grants': [{'funder': 'https://openalex.org/F4320306078', 'funder_display_name': 'U.S. Department of Defense', 'award_id': 'PC150229'}, {'funder': 'https://openalex.org/F4320306127', 'funder_display_name': 'U.S. Department of Veterans Affairs', 'award_id': 'I01BX0002653'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'CA140468'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'CA179970'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'CA168601'}], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1766417217', 'https://openalex.org/W1844925317', 'https://openalex.org/W1975609403', 'https://openalex.org/W1980998456', 'https://openalex.org/W1984209453', 'https://openalex.org/W1990164787', 'https://openalex.org/W1992624438', 'https://openalex.org/W1993060456', 'https://openalex.org/W1995039837', 'https://openalex.org/W2000107456', 'https://openalex.org/W2005563364', 'https://openalex.org/W2006169733', 'https://openalex.org/W2012589659', 'https://openalex.org/W2017919614', 'https://openalex.org/W2023033737', 'https://openalex.org/W2028268761', 'https://openalex.org/W2035933918', 'https://openalex.org/W2037700362', 'https://openalex.org/W2043888893', 'https://openalex.org/W2047565676', 'https://openalex.org/W2053585773', 'https://openalex.org/W2062703926', 'https://openalex.org/W2069636722', 'https://openalex.org/W2077438659', 'https://openalex.org/W2085847636', 'https://openalex.org/W2093774310', 'https://openalex.org/W2097226696', 'https://openalex.org/W2110841612', 'https://openalex.org/W2126127142', 'https://openalex.org/W2142661454', 'https://openalex.org/W2148483079', 'https://openalex.org/W2156923287', 'https://openalex.org/W2157980218', 'https://openalex.org/W2163604239', 'https://openalex.org/W2166324735', 'https://openalex.org/W2166767963', 'https://openalex.org/W2176198475', 'https://openalex.org/W2255181156', 'https://openalex.org/W2418971508', 'https://openalex.org/W2503523028', 'https://openalex.org/W2514821758', 'https://openalex.org/W2563499062'], 'related_works': ['https://openalex.org/W3122236002', 'https://openalex.org/W3023935924', 'https://openalex.org/W3005243004', 'https://openalex.org/W2931472946', 'https://openalex.org/W2773216890', 'https://openalex.org/W2681186693', 'https://openalex.org/W2593283143', 'https://openalex.org/W2479406918', 'https://openalex.org/W2180958531', 'https://openalex.org/W1984464970'], 'abstract_inverted_index': {'Abstract': [0], 'Prostate': [1], 'cancer': [2, 19, 120, 154, 181], 'remains': [3], 'dependent': [4], 'on': [5], 'androgen': [6, 13, 29, 59, 174, 201], 'receptor': [7, 14, 30, 60, 175, 202], 'signaling': [8, 15, 35], 'even': [9], 'after': [10], 'castration.': [11], 'Aberrant': [12], 'in': [16, 27, 79, 118, 186, 188, 207], 'castration-resistant': [17], 'prostate': [18, 119, 153, 180], 'is': [20], 'mediated': [21, 49], 'by': [22, 54, 149], 'mechanisms': [23], 'such': [24, 67, 94, 105], 'as': [25, 68, 95, 106], 'alterations': [26], 'the': [28, 43, 58, 80, 109, 123, 136, 169, 196, 200, 209], 'and': [31, 74, 90, 140, 177], 'activation': [32], 'of': [33, 57, 111, 138, 143, 147, 171, 199], 'interacting': [34], 'pathways.': [36], 'Clinical': [37], 'evidence': [38], 'confirms': [39], 'that': [40, 102, 128, 142, 163, 194], 'resistance': [41, 81, 117, 210], 'to': [42, 50, 61, 82, 88, 115, 156, 183, 211], 'next-generation': [44, 212], 'antiandrogen,': [45], 'enzalutamide,': [46, 85], 'may': [47, 203], 'be': [48], 'a': [51, 130], 'large': [52], 'extent': [53], 'alternative': [55, 197], 'splicing': [56, 103, 198], 'generate': [62], 'constitutively': [63], 'active': [64], 'splice': [65, 71], 'variants': [66, 72], 'AR-V7.': [69, 144], 'The': [70, 145], 'AR-V7': [73, 148], 'ARv567es': [75], 'have': [76, 204], 'been': [77], 'implicated': [78], 'not': [83], 'only': [84], 'but': [86], 'also': [87], 'abiraterone': [89], 'other': [91], 'conventional': [92], 'therapeutics': [93], 'taxanes.': [96], 'Numerous': [97], 'studies,': [98], 'including': [99], 'ours,': [100], 'suggest': [101], 'factors': [104], 'hnRNPA1': [107, 166], 'promote': [108], 'generation': [110], 'AR-V7,': [112, 172], 'thus': [113], 'contributing': [114], 'enzalutamide': [116, 184], 'cells.': [121], 'In': [122], 'present': [124], 'study,': [125], 'we': [126], 'discovered': [127], 'quercetin,': [129], 'naturally': [131], 'occurring': [132], 'polyphenolic': [133], 'compound,': [134], 'reduces': [135], 'expression': [137, 170], 'hnRNPA1,': [139], 'consequently,': [141], 'suppression': [146], 'quercetin': [150, 164], 'resensitizes': [151, 178], 'enzalutamide-resistant': [152, 179], 'cells': [155, 182], 'treatment': [157, 185], 'with': [158], 'enzalutamide.': [159], 'Our': [160], 'results': [161], 'indicate': [162], 'downregulates': [165, 168], 'expression,': [167], 'antagonizes': [173], 'signaling,': [176], 'vivo': [187], 'mouse': [189], 'xenografts.': [190], 'These': [191], 'findings': [192], 'demonstrate': [193], 'suppressing': [195], 'important': [205], 'implications': [206], 'overcoming': [208], 'antiandrogen': [213], 'therapy.': [214], 'Mol': [215], 'Cancer': [216], 'Ther;': [217], '16(12);': [218], '2770–9.': [219], '©2017': [220], 'AACR.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2737056430', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-12T01:24:16.807651', 'created_date': '2017-07-31'}