Publication Information

{'id': 'https://openalex.org/W2913170931', 'doi': 'https://doi.org/10.4062/biomolther.2018.234', 'title': 'Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson’s Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways', 'display_name': 'Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson’s Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways', 'publication_year': 2019, 'publication_date': '2019-02-08', 'ids': {'openalex': 'https://openalex.org/W2913170931', 'doi': 'https://doi.org/10.4062/biomolther.2018.234', 'mag': '2913170931', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30739428', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6430227'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4062/biomolther.2018.234', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2593996', 'display_name': 'Biomolecules & Therapeutics', 'issn_l': '1976-9148', 'issn': ['1976-9148', '2005-4483'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4362643885', 'host_organization_name': 'Korean Society of Applied Pharmacology', 'host_organization_lineage': ['https://openalex.org/P4362643885'], 'host_organization_lineage_names': ['Korean Society of Applied Pharmacology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc6430227?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054528536', 'display_name': 'Jin‐Sun Park', 'orcid': 'https://orcid.org/0000-0002-7775-4092'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jin-Sun Park', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112449134', 'display_name': 'Yea-Hyun Leem', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yea-Hyun Leem', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102765540', 'display_name': 'Jung‐Eun Park', 'orcid': 'https://orcid.org/0000-0001-9929-830X'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jung-Eun Park', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100648828', 'display_name': 'Do‐Yeon Kim', 'orcid': 'https://orcid.org/0000-0003-2200-7396'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Do-Yeon Kim', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea', 'institution_ids': ['https://openalex.org/I138925566']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101713488', 'display_name': 'Hee-Sun Kim', 'orcid': 'https://orcid.org/0000-0003-1889-8739'}, 'institutions': [{'id': 'https://openalex.org/I138925566', 'display_name': 'Ewha Womans University', 'ror': 'https://ror.org/053fp5c05', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I138925566']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hee-Sun Kim', 'raw_affiliation_strings': ['Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Medicine, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea', 'institution_ids': ['https://openalex.org/I138925566']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.926, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.999029, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '27', 'issue': '2', 'first_page': '178', 'last_page': '184'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9849, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13415', 'display_name': 'Calcium signaling and nucleotide metabolism', 'score': 0.9814, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mptp', 'display_name': 'MPTP', 'score': 0.8983108}, {'id': 'https://openalex.org/keywords/pars-compacta', 'display_name': 'Pars compacta', 'score': 0.75219536}], 'concepts': [{'id': 'https://openalex.org/C2778674702', 'wikidata': 'https://www.wikidata.org/wiki/Q239816', 'display_name': 'MPTP', 'level': 4, 'score': 0.8983108}, {'id': 'https://openalex.org/C2780938664', 'wikidata': 'https://www.wikidata.org/wiki/Q753278', 'display_name': 'Substantia nigra', 'level': 4, 'score': 0.8906355}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.8368317}, {'id': 'https://openalex.org/C2776773494', 'wikidata': 'https://www.wikidata.org/wiki/Q3366041', 'display_name': 'Pars compacta', 'level': 5, 'score': 0.75219536}, {'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.73618484}, {'id': 'https://openalex.org/C159167319', 'wikidata': 'https://www.wikidata.org/wiki/Q420766', 'display_name': 'Tyrosine hydroxylase', 'level': 3, 'score': 0.6343385}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.50420034}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.49549067}, {'id': 'https://openalex.org/C2780062018', 'wikidata': 'https://www.wikidata.org/wiki/Q1319792', 'display_name': 'Striatum', 'level': 3, 'score': 0.42513645}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40576947}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39196426}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35331923}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34396857}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3362972}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.3269842}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.31210703}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.29995298}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26888913}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.23018995}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4062/biomolther.2018.234', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2593996', 'display_name': 'Biomolecules & Therapeutics', 'issn_l': '1976-9148', 'issn': ['1976-9148', '2005-4483'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4362643885', 'host_organization_name': 'Korean Society of Applied Pharmacology', 'host_organization_lineage': ['https://openalex.org/P4362643885'], 'host_organization_lineage_names': ['Korean Society of Applied Pharmacology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6430227', 'pdf_url': 'https://europepmc.org/articles/pmc6430227?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430227', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30739428', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6430227', 'pdf_url': 'https://europepmc.org/articles/pmc6430227?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.45, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320322120', 'funder_display_name': 'National Research Foundation of Korea', 'award_id': '2018R1A2B6003074'}, {'funder': 'https://openalex.org/F4320322120', 'funder_display_name': 'National Research Foundation of Korea', 'award_id': '2016R1A6A3A11930120'}, {'funder': 'https://openalex.org/F4320322120', 'funder_display_name': 'National Research Foundation of Korea', 'award_id': '2010-0027945'}], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1166587220', 'https://openalex.org/W1653152132', 'https://openalex.org/W1977334935', 'https://openalex.org/W1979458217', 'https://openalex.org/W2009517899', 'https://openalex.org/W2022911097', 'https://openalex.org/W2032146350', 'https://openalex.org/W2055285423', 'https://openalex.org/W2064428225', 'https://openalex.org/W2065746707', 'https://openalex.org/W2087051641', 'https://openalex.org/W2088976086', 'https://openalex.org/W2089024157', 'https://openalex.org/W2102697857', 'https://openalex.org/W2125740363', 'https://openalex.org/W2169890833', 'https://openalex.org/W2410790641', 'https://openalex.org/W2549842065', 'https://openalex.org/W2563707435', 'https://openalex.org/W2595455544', 'https://openalex.org/W2622167732', 'https://openalex.org/W2748930167', 'https://openalex.org/W2768455179', 'https://openalex.org/W2800752441', 'https://openalex.org/W2801838524', 'https://openalex.org/W4210978727', 'https://openalex.org/W4211044101'], 'related_works': ['https://openalex.org/W3049065873', 'https://openalex.org/W2464629686', 'https://openalex.org/W2359931691', 'https://openalex.org/W2178039548', 'https://openalex.org/W2114361548', 'https://openalex.org/W2027972413', 'https://openalex.org/W2018460396', 'https://openalex.org/W1998281806', 'https://openalex.org/W1971902743', 'https://openalex.org/W154169386'], 'abstract_inverted_index': {"Parkinson's": [0, 48], 'disease': [1, 5, 49], 'is': [2], 'a': [3, 29, 44], 'neurodegenerative': [4, 114], 'characterized': [6], 'by': [7, 61, 73, 195], 'the': [8, 15, 21, 35, 54, 64, 74, 97, 105, 123, 153, 163, 175, 197], 'progressive': [9], 'loss': [10, 59, 83], 'of': [11, 84, 108, 122, 160, 165, 177], 'dopaminergic': [12], 'neurons': [13], 'within': [14], 'substantia': [16, 98], 'nigra': [17], 'pars': [18], 'compacta.': [19], 'In': [20, 77], 'present': [22], 'study,': [23], 'we': [24, 116], 'investigated': [25, 117], 'whether': [26, 118], 'β-Lapachone': [27], '(β-LAP),': [28], 'natural': [30], 'naphthoquinone': [31], 'compound': [32], 'isolated': [33], 'from': [34], 'lapacho': [36], 'tree': [37], '(Tabebuia': [38], 'avellanedae),': [39], 'elicits': [40], 'neuroprotective': [41, 106, 190], 'effects': [42], 'in': [43, 63, 96, 113, 129, 144, 181, 192, 201], '1-methyl-4-phenyl-1,2,3,6-': [45], 'tetrahydropyridine': [46], '(MPTP)-induced': [47], 'mouse': [50, 131], 'model.': [51], 'β-LAP': [52, 79, 119, 140, 151, 172, 188], 'reduced': [53], 'tyrosine': [55], 'hydroxylase': [56], '(TH)-immunoreactive': [57], 'fiber': [58], 'induced': [60], 'MPTP': [62], 'dorsolateral': [65], 'striatum,': [66], 'and': [67, 88, 135, 156, 162, 179], 'alleviated': [68], 'motor': [69], 'dysfunction': [70], 'as': [71], 'determined': [72], 'rotarod': [75], 'test.': [76], 'addition,': [78], 'protected': [80], 'against': [81], 'MPTP-induced': [82], 'TH': [85], 'positive': [86], 'neurons,': [87], 'upregulated': [89], 'B-cell': [90], 'lymphoma': [91], '2': [92], 'protein': [93, 169], '(Bcl-2)': [94], 'expression': [95, 143], 'nigra.': [99], 'Based': [100], 'on': [101, 104], 'previous': [102], 'reports': [103], 'role': [107], 'nuclear': [109, 154], 'factor-E2-related': [110], 'factor-2': [111], '(Nrf2)': [112], 'diseases,': [115], 'induces': [120], 'upregulation': [121], 'Nrf2-hemeoxygenae-1': [124], '(HO-1)': [125], 'signaling': [126, 199], 'pathway': [127], 'molecules': [128], 'MPTP-injected': [130, 193], 'brains.': [132], 'Western': [133], 'blot': [134], 'immunohistochemical': [136], 'analyses': [137], 'indicated': [138], 'that': [139, 187], 'increased': [141, 152, 174], 'HO-1': [142], 'glial': [145], 'fibrillary': [146], 'acidic': [147], 'protein-positive': [148], 'astrocytes.': [149, 182, 202], 'Moreover,': [150], 'translocation': [155], 'DNA': [157], 'binding': [158], 'activity': [159], 'Nrf2,': [161], 'phosphorylation': [164], 'upstream': [166], 'adenosine': [167], 'monophosphate-activated': [168], 'kinase': [170], '(AMPK).': [171], 'also': [173], 'localization': [176], 'p-AMPK': [178], 'Nrf2': [180], 'Collectively,': [183], 'our': [184], 'data': [185], 'suggest': [186], 'exerts': [189], 'effect': [191], 'mice': [194], 'upregulating': [196], 'p-AMPK/Nrf2/HO-1': [198], 'pathways': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2913170931', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2024-12-27T19:58:04.158015', 'created_date': '2019-02-21'}