Title: Detecting parkinsonian degeneration in lateroventral tier of substantia nigra pars compacta with MRI
Abstract: Dopaminergic neurons in substantia nigra pars compacta contain neuromelanin. Parkinson's disease causes profound depigmentation of substantia nigra pars compacta. At the time of parkinsonian symptom onset, approximately 50% of melanized dopaminergic neurons in substantia nigra pars compacta have died. Multiple histopathology studies dating back to the 1930s observed a loss of these melanized neurons occurring in the lateroventral tier of substantia nigra pars compacta. Delineation of substantia nigra pars compacta in images from magnetic resonance imaging (MRI) scanners has been hampered by a lack of sensitivity to neuromelanin. The creation of neuromelanin-sensitive MRI has allowed for accurate delineation of substantia nigra pars compacta. In this chapter, we provide an overview of neuromelanin-sensitive MRI and detail studies using neuromelanin-sensitive MRI to study cell loss in the lateroventral tier of substantia nigra.
Publication Year: 2020
Publication Date: 2020-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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