Publication Information

{'id': 'https://openalex.org/W2018460396', 'doi': 'https://doi.org/10.1097/nen.0b013e3181b35e41', 'title': 'Acute and Chronic 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Administrations Elicit Similar Microglial Activation in the Substantia Nigra of Monkeys', 'display_name': 'Acute and Chronic 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Administrations Elicit Similar Microglial Activation in the Substantia Nigra of Monkeys', 'publication_year': 2009, 'publication_date': '2009-08-21', 'ids': {'openalex': 'https://openalex.org/W2018460396', 'doi': 'https://doi.org/10.1097/nen.0b013e3181b35e41', 'mag': '2018460396', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19680145'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/nen.0b013e3181b35e41', 'pdf_url': 'https://academic.oup.com/jnen/article-pdf/68/9/977/9559589/68-9-977.pdf', 'source': {'id': 'https://openalex.org/S38023437', 'display_name': 'Journal of Neuropathology & Experimental Neurology', 'issn_l': '0022-3069', 'issn': ['0022-3069', '1554-6578'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/jnen/article-pdf/68/9/977/9559589/68-9-977.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000596324', 'display_name': 'Marianne Vázquez‐Claverie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Marianne Vázquez-Claverie', 'raw_affiliation_strings': ['Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057756574', 'display_name': 'Pablo Garrido‐Gil', 'orcid': 'https://orcid.org/0000-0001-7734-8783'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Pablo Garrido-Gil', 'raw_affiliation_strings': ['Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106264915', 'display_name': 'Waldy San Sebastián', 'orcid': 'https://orcid.org/0000-0002-2776-7944'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Waldy San Sebastián', 'raw_affiliation_strings': ['Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073982553', 'display_name': 'Amaya Izal‐Azcárate', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Amaya Izal-Azcárate', 'raw_affiliation_strings': ['Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074222245', 'display_name': 'Silvia Belzunegui', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Silvia Belzunegui', 'raw_affiliation_strings': ['Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013205418', 'display_name': 'Irene Marcilla', 'orcid': 'https://orcid.org/0000-0003-0536-1473'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Irene Marcilla', 'raw_affiliation_strings': ['Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110187181', 'display_name': 'Berta López', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Berta López', 'raw_affiliation_strings': ['Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5047004228', 'display_name': 'M. R. Luquín', 'orcid': 'https://orcid.org/0000-0002-5594-1794'}, 'institutions': [{'id': 'https://openalex.org/I88155538', 'display_name': 'Universidad de Navarra', 'ror': 'https://ror.org/02rxc7m23', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I88155538']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'María-Rosario Luquin', 'raw_affiliation_strings': ['Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Regenerative Therapy, Department of Neurology and Neuroscience Division, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain', 'institution_ids': ['https://openalex.org/I88155538']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.311, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.91197, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '68', 'issue': '9', 'first_page': '977', 'last_page': '984'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mptp', 'display_name': 'MPTP', 'score': 0.9818944}, {'id': 'https://openalex.org/keywords/pars-compacta', 'display_name': 'Pars compacta', 'score': 0.9226351}], 'concepts': [{'id': 'https://openalex.org/C2778674702', 'wikidata': 'https://www.wikidata.org/wiki/Q239816', 'display_name': 'MPTP', 'level': 4, 'score': 0.9818944}, {'id': 'https://openalex.org/C2780938664', 'wikidata': 'https://www.wikidata.org/wiki/Q753278', 'display_name': 'Substantia nigra', 'level': 4, 'score': 0.96939075}, {'id': 'https://openalex.org/C2776773494', 'wikidata': 'https://www.wikidata.org/wiki/Q3366041', 'display_name': 'Pars compacta', 'level': 5, 'score': 0.9226351}, {'id': 'https://openalex.org/C2779830541', 'wikidata': 'https://www.wikidata.org/wiki/Q1622829', 'display_name': 'Microglia', 'level': 3, 'score': 0.74064326}, {'id': 'https://openalex.org/C2780948874', 'wikidata': 'https://www.wikidata.org/wiki/Q640562', 'display_name': 'Ventral tegmental area', 'level': 4, 'score': 0.7387593}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.6227518}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.52668417}, {'id': 'https://openalex.org/C87753298', 'wikidata': 'https://www.wikidata.org/wiki/Q17157137', 'display_name': 'Neuroinflammation', 'level': 3, 'score': 0.4904008}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.45985892}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41309237}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.37939546}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.341873}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.34093636}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23509485}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0994108}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.07918948}], 'mesh': [{'descriptor_ui': 'D020267', 'descriptor_name': 'MPTP Poisoning', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D020267', 'descriptor_name': 'MPTP Poisoning', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015632', 'descriptor_name': '1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015632', 'descriptor_name': '1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020267', 'descriptor_name': 'MPTP Poisoning', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020267', 'descriptor_name': 'MPTP Poisoning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008252', 'descriptor_name': 'Macaca fascicularis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009498', 'descriptor_name': 'Neurotoxins', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D009498', 'descriptor_name': 'Neurotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/nen.0b013e3181b35e41', 'pdf_url': 'https://academic.oup.com/jnen/article-pdf/68/9/977/9559589/68-9-977.pdf', 'source': {'id': 'https://openalex.org/S38023437', 'display_name': 'Journal of Neuropathology & Experimental Neurology', 'issn_l': '0022-3069', 'issn': ['0022-3069', '1554-6578'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19680145', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/nen.0b013e3181b35e41', 'pdf_url': 'https://academic.oup.com/jnen/article-pdf/68/9/977/9559589/68-9-977.pdf', 'source': {'id': 'https://openalex.org/S38023437', 'display_name': 'Journal of Neuropathology & Experimental Neurology', 'issn_l': '0022-3069', 'issn': ['0022-3069', '1554-6578'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1587360940', 'https://openalex.org/W1766174542', 'https://openalex.org/W1963690624', 'https://openalex.org/W1973703480', 'https://openalex.org/W1974924674', 'https://openalex.org/W1975331070', 'https://openalex.org/W1994004433', 'https://openalex.org/W1994102729', 'https://openalex.org/W1997124326', 'https://openalex.org/W2011094963', 'https://openalex.org/W2015715527', 'https://openalex.org/W2019010892', 'https://openalex.org/W2021899761', 'https://openalex.org/W2022505547', 'https://openalex.org/W2037367554', 'https://openalex.org/W2039542458', 'https://openalex.org/W2043290296', 'https://openalex.org/W2043676089', 'https://openalex.org/W2048809344', 'https://openalex.org/W2052562838', 'https://openalex.org/W2056196016', 'https://openalex.org/W2056546282', 'https://openalex.org/W2067360858', 'https://openalex.org/W2078056296', 'https://openalex.org/W2080512970', 'https://openalex.org/W2084089231', 'https://openalex.org/W2090409342', 'https://openalex.org/W2091184602', 'https://openalex.org/W2095559945', 'https://openalex.org/W2098097762', 'https://openalex.org/W2105382539', 'https://openalex.org/W2116916791', 'https://openalex.org/W2117442313', 'https://openalex.org/W2120812632', 'https://openalex.org/W2128631317', 'https://openalex.org/W2147830608', 'https://openalex.org/W2159316873', 'https://openalex.org/W2162565534', 'https://openalex.org/W2163751922', 'https://openalex.org/W2164457608', 'https://openalex.org/W2167924904', 'https://openalex.org/W2171417336', 'https://openalex.org/W2765559182', 'https://openalex.org/W4210981518'], 'related_works': ['https://openalex.org/W4248431072', 'https://openalex.org/W3049065873', 'https://openalex.org/W2884144427', 'https://openalex.org/W2359931691', 'https://openalex.org/W2178039548', 'https://openalex.org/W2090181211', 'https://openalex.org/W2035149159', 'https://openalex.org/W2018460396', 'https://openalex.org/W1992832854', 'https://openalex.org/W154169386'], 'abstract_inverted_index': {'Increasing': [0], 'evidence': [1], 'suggests': [2, 186], 'a': [3], 'pivotal': [4], 'role': [5], 'for': [6], 'neuroinflammation': [7], 'in': [8, 19, 36, 56, 94, 107, 115, 120, 137, 194], 'the': [9, 30, 37, 57, 67, 82, 95, 108, 138, 149, 166, 179, 188], 'pathogenesis': [10], 'of': [11, 32, 46, 91, 126, 133, 148, 169, 191], 'Parkinson': [12, 195], 'disease,': [13], 'but': [14], 'whether': [15], 'activated': [16, 33, 134], 'microglia': [17], 'participate': [18], 'disease': [20, 196], 'progression': [21], 'remains': [22], 'unclear.': [23], 'To': [24], 'clarify': [25], 'this': [26], 'issue,': [27], 'we': [28], 'determined': [29], 'numbers': [31, 132], 'microglial': [34, 105, 135, 158, 205], 'cells': [35, 136, 193], 'substantia': [38, 96, 139], 'nigra': [39, 97, 140], 'pars': [40, 98, 141], 'compacta': [41, 99, 142], 'and': [42, 49, 100, 104, 171], 'ventral': [43, 101], 'tegmental': [44, 102], 'area': [45, 103], 'monkeys': [47, 73, 129], 'subacutely': [48], 'chronically': [50, 71], 'exposed': [51], 'to': [52, 146, 161], '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine': [53], '(MPTP).': [54], 'Monkeys': [55], 'subacute': [58, 150], 'MPTP': [59, 69, 84, 87, 112, 151, 170], 'treatment': [60, 113, 122, 152], 'group': [61], 'were': [62, 74, 144], 'killed': [63, 75], '1': [64], 'week': [65], 'after': [66, 81], 'last': [68, 83], 'injection;': [70], 'treated': [72], 'either': [76], '6': [77], 'or': [78], '35': [79], 'months': [80], 'injection.': [85], 'Subacute': [86], 'administration': [88, 181], 'induced': [89, 163], 'loss': [90], 'dopaminergic': [92, 117], 'neurons': [93], 'activation': [106, 159], 'same': [109], 'areas.': [110], 'Chronic': [111], 'resulted': [114], 'greater': [116], 'neuron': [118], 'depletion': [119], 'both': [121], 'groups.': [123], 'Both': [124], 'groups': [125], 'chronic': [127], 'MPTP-treated': [128], 'showed': [130], 'increased': [131, 204], 'that': [143, 157, 172, 187], 'similar': [145], 'those': [147], 'group.': [153], 'These': [154], 'results': [155], 'indicate': [156], 'seems': [160], 'be': [162, 200], 'mainly': [164], 'by': [165], 'toxic': [167], 'effects': [168], 'it': [173], 'does': [174], 'not': [175, 198], 'further': [176], 'progress': [177], 'once': [178], 'toxin': [180], 'has': [182], 'been': [183], 'terminated.': [184], 'This': [185], 'progressive': [189], 'degeneration': [190], 'nigral': [192], 'may': [197], 'necessarily': [199], 'associated': [201], 'with': [202], 'progressively': [203], 'activation.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2018460396', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-14T03:31:14.140849', 'created_date': '2016-06-24'}