Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2886706562', 'doi': 'https://doi.org/10.1038/s41467-018-05652-0', 'title': 'Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine', 'display_name': 'Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine', 'publication_year': 2018, 'publication_date': '2018-08-13', 'ids': {'openalex': 'https://openalex.org/W2886706562', 'doi': 'https://doi.org/10.1038/s41467-018-05652-0', 'mag': '2886706562', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30115924', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6095916'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-018-05652-0', 'pdf_url': 'https://www.nature.com/articles/s41467-018-05652-0.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41467-018-05652-0.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042378958', 'display_name': 'Leila S. Ross', 'orcid': 'https://orcid.org/0000-0003-4360-5213'}, 'institutions': [{'id': 'https://openalex.org/I2799503643', 'display_name': 'Columbia University Irving Medical Center', 'ror': 'https://ror.org/01esghr10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799503643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leila S. Ross', 'raw_affiliation_strings': ['Columbia University Irving Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Columbia University Irving Medical Center', 'institution_ids': ['https://openalex.org/I2799503643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084273651', 'display_name': 'Satish K. Dhingra', 'orcid': 'https://orcid.org/0000-0002-3893-1615'}, 'institutions': [{'id': 'https://openalex.org/I2799503643', 'display_name': 'Columbia University Irving Medical Center', 'ror': 'https://ror.org/01esghr10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799503643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Satish K. Dhingra', 'raw_affiliation_strings': ['Columbia University Irving Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Columbia University Irving Medical Center', 'institution_ids': ['https://openalex.org/I2799503643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044913327', 'display_name': 'Sachel Mok', 'orcid': 'https://orcid.org/0000-0002-9605-0154'}, 'institutions': [{'id': 'https://openalex.org/I2799503643', 'display_name': 'Columbia University Irving Medical Center', 'ror': 'https://ror.org/01esghr10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799503643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sachel Mok', 'raw_affiliation_strings': ['Columbia University Irving Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Columbia University Irving Medical Center', 'institution_ids': ['https://openalex.org/I2799503643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038988231', 'display_name': 'Tomas Yeo', 'orcid': 'https://orcid.org/0000-0003-2923-6060'}, 'institutions': [{'id': 'https://openalex.org/I2799503643', 'display_name': 'Columbia University Irving Medical Center', 'ror': 'https://ror.org/01esghr10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799503643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tomas Yeo', 'raw_affiliation_strings': ['Columbia University Irving Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Columbia University Irving Medical Center', 'institution_ids': ['https://openalex.org/I2799503643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061788363', 'display_name': 'Kathryn J. Wicht', 'orcid': 'https://orcid.org/0000-0001-6145-9956'}, 'institutions': [{'id': 'https://openalex.org/I2799503643', 'display_name': 'Columbia University Irving Medical Center', 'ror': 'https://ror.org/01esghr10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799503643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kathryn J. Wicht', 'raw_affiliation_strings': ['Columbia University Irving Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Columbia University Irving Medical Center', 'institution_ids': ['https://openalex.org/I2799503643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011902670', 'display_name': 'Krittikorn Kümpornsin', 'orcid': 'https://orcid.org/0000-0001-9427-7139'}, 'institutions': [{'id': 'https://openalex.org/I2799503643', 'display_name': 'Columbia University Irving Medical Center', 'ror': 'https://ror.org/01esghr10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799503643']}, {'id': 'https://openalex.org/I2802476451', 'display_name': 'Wellcome Sanger Institute', 'ror': 'https://ror.org/05cy4wa09', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802476451', 'https://openalex.org/I87048295']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Krittikorn Kümpornsin', 'raw_affiliation_strings': ['Columbia University Irving Medical Center', 'The Wellcome Trust Sanger Institute [Cambridge]'], 'affiliations': [{'raw_affiliation_string': 'Columbia University Irving Medical Center', 'institution_ids': ['https://openalex.org/I2799503643']}, {'raw_affiliation_string': 'The Wellcome Trust Sanger Institute [Cambridge]', 'institution_ids': ['https://openalex.org/I2802476451']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011546643', 'display_name': 'Shannon Takala‐Harrison', 'orcid': 'https://orcid.org/0000-0003-4674-8500'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shannon Takala-Harrison', 'raw_affiliation_strings': ['University of Maryland School of Medicine'], 'affiliations': [{'raw_affiliation_string': 'University of Maryland School of Medicine', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089661257', 'display_name': 'Benoît Witkowski', 'orcid': 'https://orcid.org/0000-0002-8599-6382'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Benoit Witkowski', 'raw_affiliation_strings': ['Malaria Molecular Epidemiology'], 'affiliations': [{'raw_affiliation_string': 'Malaria Molecular Epidemiology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012815299', 'display_name': 'Rick M. Fairhurst', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159747', 'display_name': 'Vector Oncology (United States)', 'ror': 'https://ror.org/05mkxvs25', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210159747']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rick M. Fairhurst', 'raw_affiliation_strings': ['Department of Health and Human Services [Baltimore, MD, USA]', 'Laboratory of Malaria and Vector Research'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Malaria and Vector Research', 'institution_ids': ['https://openalex.org/I4210159747']}, {'raw_affiliation_string': 'Department of Health and Human Services [Baltimore, MD, USA]', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020036182', 'display_name': 'Frédéric Ariey', 'orcid': 'https://orcid.org/0000-0002-0680-1090'}, 'institutions': [{'id': 'https://openalex.org/I4210141964', 'display_name': 'Institut Cochin', 'ror': 'https://ror.org/051sk4035', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210141964']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Frederic Ariey', 'raw_affiliation_strings': ['Institut Cochin'], 'affiliations': [{'raw_affiliation_string': 'Institut Cochin', 'institution_ids': ['https://openalex.org/I4210141964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090394978', 'display_name': 'Didier Ménard', 'orcid': 'https://orcid.org/0000-0003-1357-4495'}, 'institutions': [{'id': 'https://openalex.org/I4210087514', 'display_name': 'Biologie et Génétique des Interactions Plante-Parasite', 'ror': 'https://ror.org/0026vdt21', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I131077856', 'https://openalex.org/I24906876', 'https://openalex.org/I4210087514', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210117091', 'https://openalex.org/I4399657933']}, {'id': 'https://openalex.org/I4387153587', 'display_name': 'Biologie des interactions hôte-parasite', 'ror': 'https://ror.org/05akjb009', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I157536573', 'https://openalex.org/I4387153587']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Didier Menard', 'raw_affiliation_strings': ['Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions', 'Malaria Molecular Epidemiology'], 'affiliations': [{'raw_affiliation_string': 'Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions', 'institution_ids': ['https://openalex.org/I4210087514', 'https://openalex.org/I4387153587']}, {'raw_affiliation_string': 'Malaria Molecular Epidemiology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071314941', 'display_name': 'David A. Fidock', 'orcid': 'https://orcid.org/0000-0001-6753-8938'}, 'institutions': [{'id': 'https://openalex.org/I2799503643', 'display_name': 'Columbia University Irving Medical Center', 'ror': 'https://ror.org/01esghr10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799503643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David A. Fidock', 'raw_affiliation_strings': ['Columbia University Irving Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Columbia University Irving Medical Center', 'institution_ids': ['https://openalex.org/I2799503643']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'apc_paid': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'fwci': 28.818, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 208, 'citation_normalized_percentile': {'value': 0.999976, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '9', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9759, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/piperaquine', 'display_name': 'Piperaquine', 'score': 0.93190575}, {'id': 'https://openalex.org/keywords/amodiaquine', 'display_name': 'Amodiaquine', 'score': 0.42818576}], 'concepts': [{'id': 'https://openalex.org/C2777616469', 'wikidata': 'https://www.wikidata.org/wiki/Q7197338', 'display_name': 'Piperaquine', 'level': 5, 'score': 0.93190575}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.80888724}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7244772}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.5896298}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.5792684}, {'id': 'https://openalex.org/C2777425658', 'wikidata': 'https://www.wikidata.org/wiki/Q422438', 'display_name': 'Chloroquine', 'level': 3, 'score': 0.5033104}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.4723407}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4618982}, {'id': 'https://openalex.org/C2776120307', 'wikidata': 'https://www.wikidata.org/wiki/Q426921', 'display_name': 'Artemisinin', 'level': 4, 'score': 0.45798957}, {'id': 'https://openalex.org/C2776992834', 'wikidata': 'https://www.wikidata.org/wiki/Q239569', 'display_name': 'Amodiaquine', 'level': 4, 'score': 0.42818576}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.08097482}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016778', 'descriptor_name': 'Malaria, Falciparum', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016778', 'descriptor_name': 'Malaria, Falciparum', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': True}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011804', 'descriptor_name': 'Quinolines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002160', 'descriptor_name': 'Cambodia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048430', 'descriptor_name': 'Cell Shape', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048430', 'descriptor_name': 'Cell Shape', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018628', 'descriptor_name': 'Gene Dosage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072669', 'descriptor_name': 'Gene Editing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006239', 'descriptor_name': 'Haplotypes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006239', 'descriptor_name': 'Haplotypes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016778', 'descriptor_name': 'Malaria, Falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010271', 'descriptor_name': 'Parasites', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010271', 'descriptor_name': 'Parasites', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D010271', 'descriptor_name': 'Parasites', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010271', 'descriptor_name': 'Parasites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011804', 'descriptor_name': 'Quinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011804', 'descriptor_name': 'Quinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014700', 'descriptor_name': 'Verapamil', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D014700', 'descriptor_name': 'Verapamil', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014700', 'descriptor_name': 'Verapamil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 9, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-018-05652-0', 'pdf_url': 'https://www.nature.com/articles/s41467-018-05652-0.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.science/hal-02558701', 'pdf_url': 'https://hal.science/hal-02558701/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/9e15ba8777674417b0e16955209c6ccc', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6095916', 'pdf_url': 'https://europepmc.org/articles/pmc6095916?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.science/hal-02558701/file/s41467-018-05652-0.pdf', 'pdf_url': 'https://hal.science/hal-02558701/file/s41467-018-05652-0.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-02558701/document', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-02558701/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-02558701/file/s41467-018-05652-0.pdf', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-02558701/file/s41467-018-05652-0.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095916', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30115924', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-018-05652-0', 'pdf_url': 'https://www.nature.com/articles/s41467-018-05652-0.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320337355', 'funder_display_name': 'National Institute of Allergy and Infectious Diseases', 'award_id': 'R01 AI124678'}, {'funder': 'https://openalex.org/F4320337355', 'funder_display_name': 'National Institute of Allergy and Infectious Diseases', 'award_id': 'R01 AI125579'}, {'funder': 'https://openalex.org/F4320337355', 'funder_display_name': 'National Institute of Allergy and Infectious Diseases', 'award_id': 'R01 AI50234'}, {'funder': 'https://openalex.org/F4320337355', 'funder_display_name': 'National Institute of Allergy and Infectious Diseases', 'award_id': 'F32 AI120578'}], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W1525810389', 'https://openalex.org/W1694215848', 'https://openalex.org/W1906140483', 'https://openalex.org/W1964575165', 'https://openalex.org/W1969571661', 'https://openalex.org/W1974720373', 'https://openalex.org/W1979932633', 'https://openalex.org/W1984669077', 'https://openalex.org/W1984979458', 'https://openalex.org/W1993347313', 'https://openalex.org/W1996418116', 'https://openalex.org/W2012963579', 'https://openalex.org/W2022738557', 'https://openalex.org/W2024791353', 'https://openalex.org/W2037350416', 'https://openalex.org/W2053264137', 'https://openalex.org/W2054691901', 'https://openalex.org/W2055730063', 'https://openalex.org/W2074450319', 'https://openalex.org/W2076050649', 'https://openalex.org/W2086623491', 'https://openalex.org/W2088387917', 'https://openalex.org/W2097263871', 'https://openalex.org/W2100465176', 'https://openalex.org/W2101539811', 'https://openalex.org/W2103439634', 'https://openalex.org/W2105761183', 'https://openalex.org/W2108523891', 'https://openalex.org/W2113516463', 'https://openalex.org/W2124634096', 'https://openalex.org/W2129428401', 'https://openalex.org/W2129680162', 'https://openalex.org/W2132923209', 'https://openalex.org/W2144991173', 'https://openalex.org/W2154558221', 'https://openalex.org/W2156469502', 'https://openalex.org/W2158780951', 'https://openalex.org/W2158967285', 'https://openalex.org/W2166363384', 'https://openalex.org/W2169329132', 'https://openalex.org/W2171102256', 'https://openalex.org/W2195607601', 'https://openalex.org/W2221909792', 'https://openalex.org/W2229864756', 'https://openalex.org/W2273900672', 'https://openalex.org/W2307970348', 'https://openalex.org/W2344075384', 'https://openalex.org/W2397788564', 'https://openalex.org/W2411068755', 'https://openalex.org/W2467259677', 'https://openalex.org/W2497068279', 'https://openalex.org/W2530569707', 'https://openalex.org/W2547042202', 'https://openalex.org/W2547295550', 'https://openalex.org/W2553625841', 'https://openalex.org/W2566212497', 'https://openalex.org/W2579721738', 'https://openalex.org/W2584480708', 'https://openalex.org/W2595820219', 'https://openalex.org/W2613934809', 'https://openalex.org/W2735068327', 'https://openalex.org/W2735848561', 'https://openalex.org/W2742753960', 'https://openalex.org/W2755621348', 'https://openalex.org/W2789830696', 'https://openalex.org/W2803023244', 'https://openalex.org/W4210312275', 'https://openalex.org/W4211051628'], 'related_works': ['https://openalex.org/W3035397081', 'https://openalex.org/W2470168894', 'https://openalex.org/W2406164295', 'https://openalex.org/W2396351265', 'https://openalex.org/W2348030123', 'https://openalex.org/W2120009689', 'https://openalex.org/W2101775642', 'https://openalex.org/W2071107945', 'https://openalex.org/W1848139203', 'https://openalex.org/W1587738737'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'widely': [2], 'used': [3], 'antimalarial': [4], 'combination': [5], 'therapy': [6], 'dihydroartemisinin': [7], '+': [8, 11, 44], 'piperaquine': [9], '(DHA': [10], 'PPQ)': [12], 'has': [13], 'failed': [14], 'in': [15, 28, 34, 50, 129, 136, 147], 'Cambodia.': [16], 'Here,': [17], 'we': [18, 74], 'perform': [19], 'a': [20, 25, 114, 152], 'genomic': [21], 'analysis': [22], 'that': [23, 76, 144], 'reveals': [24], 'rapid': [26], 'increase': [27], 'the': [29, 35, 53, 77], 'prevalence': [30], 'of': [31, 157], 'novel': [32], 'mutations': [33, 48, 62, 83, 98, 146], 'Plasmodium': [36], 'falciparum': [37], 'chloroquine': [38], 'resistance': [39, 57, 86], 'transporter': [40], 'PfCRT': [41, 61, 148], 'following': [42], 'DHA': [43], 'PPQ': [45, 122, 158], 'implementation.': [46], 'These': [47, 97], 'occur': [49], 'parasites': [51, 66, 101, 133], 'harboring': [52], 'K13': [54], 'C580Y': [55], 'artemisinin': [56], 'marker.': [58], 'By': [59], 'introducing': [60], 'into': [63], 'sensitive': [64], 'Dd2': [65, 100, 108, 132], 'or': [67, 81], 'removing': [68], 'them': [69], 'from': [70], 'resistant': [71], 'Cambodian': [72, 137], 'isolates,': [73], 'show': [75], 'H97Y,': [78], 'F145I,': [79], 'M343L,': [80], 'G353V': [82], 'each': [84], 'confer': [85], 'to': [87, 102], 'PPQ,': [88], 'albeit': [89], 'with': [90], 'fitness': [91], 'costs': [92], 'for': [93, 121], 'all': [94], 'but': [95, 134], 'M343L.': [96], 'sensitize': [99], 'chloroquine,': [103], 'amodiaquine,': [104], 'and': [105, 155], 'quinine.': [106], 'In': [107], 'parasites,': [109], 'multicopy': [110], 'plasmepsin': [111], '2': [112], ',': [113], 'candidate': [115], 'molecular': [116, 153], 'marker,': [117], 'is': [118], 'not': [119, 135], 'necessary': [120], 'resistance.': [123, 159], 'Distended': [124], 'digestive': [125], 'vacuoles': [126], 'were': [127], 'observed': [128], 'pfcrt': [130], '-edited': [131], 'isolates.': [138], 'Our': [139], 'findings': [140], 'provide': [141], 'compelling': [142], 'evidence': [143], 'emerging': [145], 'can': [149], 'serve': [150], 'as': [151], 'marker': [154], 'mediator': [156]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2886706562', 'counts_by_year': [{'year': 2024, 'cited_by_count': 21}, {'year': 2023, 'cited_by_count': 30}, {'year': 2022, 'cited_by_count': 36}, {'year': 2021, 'cited_by_count': 39}, {'year': 2020, 'cited_by_count': 41}, {'year': 2019, 'cited_by_count': 32}, {'year': 2018, 'cited_by_count': 7}], 'updated_date': '2024-12-15T11:37:32.232411', 'created_date': '2018-08-22'}