Publication Information

{'id': 'https://openalex.org/W2470168894', 'doi': 'https://doi.org/10.4269/ajtmh.1987.36.3', 'title': 'Amodiaquine Less Effective than Chloroquine in the Treatment of Falciparum Malaria in the Philippines', 'display_name': 'Amodiaquine Less Effective than Chloroquine in the Treatment of Falciparum Malaria in the Philippines', 'publication_year': 1987, 'publication_date': '1987-01-01', 'ids': {'openalex': 'https://openalex.org/W2470168894', 'doi': 'https://doi.org/10.4269/ajtmh.1987.36.3', 'mag': '2470168894', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3544892'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.1987.36.3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112144750', 'display_name': 'George Watt', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'George Watt', 'raw_affiliation_strings': ['U.S. Naval Medical Research Unit No. 2, APO San Francisco 96528,'], 'affiliations': [{'raw_affiliation_string': 'U.S. Naval Medical Research Unit No. 2, APO San Francisco 96528,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111957799', 'display_name': 'Gary W. Long', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gary W. Long', 'raw_affiliation_strings': ['U.S. Naval Medical Research Unit No. 2, APO San Francisco 96528,'], 'affiliations': [{'raw_affiliation_string': 'U.S. Naval Medical Research Unit No. 2, APO San Francisco 96528,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000174315', 'display_name': 'Laurena P. Padre', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Laurena Padre', 'raw_affiliation_strings': ['Philippine Ministry of Health,'], 'affiliations': [{'raw_affiliation_string': 'Philippine Ministry of Health,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085454675', 'display_name': 'Perla Alban', 'orcid': None}, 'institutions': [], 'countries': ['PH'], 'is_corresponding': False, 'raw_author_name': 'Perla Alban', 'raw_affiliation_strings': ['and San Lazaro Hospital, Manila, Philippines'], 'affiliations': [{'raw_affiliation_string': 'and San Lazaro Hospital, Manila, Philippines', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068199596', 'display_name': 'Ruperto Sangalang', 'orcid': None}, 'institutions': [], 'countries': ['PH'], 'is_corresponding': False, 'raw_author_name': 'Ruperto Sangalang', 'raw_affiliation_strings': ['and San Lazaro Hospital, Manila, Philippines'], 'affiliations': [{'raw_affiliation_string': 'and San Lazaro Hospital, Manila, Philippines', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024687142', 'display_name': 'Catherine P. Ranoa', 'orcid': None}, 'institutions': [], 'countries': ['PH'], 'is_corresponding': False, 'raw_author_name': 'Catherine P. Ranoa', 'raw_affiliation_strings': ['and San Lazaro Hospital, Manila, Philippines'], 'affiliations': [{'raw_affiliation_string': 'and San Lazaro Hospital, Manila, Philippines', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030464419', 'display_name': 'Larry W. Laughlin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Larry W. Laughlin', 'raw_affiliation_strings': ['U.S. Naval Medical Research Unit No. 2, APO San Francisco 96528,'], 'affiliations': [{'raw_affiliation_string': 'U.S. Naval Medical Research Unit No. 2, APO San Francisco 96528,', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.15, 'has_fulltext': False, 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.766426, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '36', 'issue': '1', 'first_page': '3', 'last_page': '8'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Antibiotics Pharmacokinetics and Efficacy', 'score': 0.9381, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9357, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/amodiaquine', 'display_name': 'Amodiaquine', 'score': 0.9907073}], 'concepts': [{'id': 'https://openalex.org/C2776992834', 'wikidata': 'https://www.wikidata.org/wiki/Q239569', 'display_name': 'Amodiaquine', 'level': 4, 'score': 0.9907073}, {'id': 'https://openalex.org/C2777425658', 'wikidata': 'https://www.wikidata.org/wiki/Q422438', 'display_name': 'Chloroquine', 'level': 3, 'score': 0.932737}, {'id': 'https://openalex.org/C2775867548', 'wikidata': 'https://www.wikidata.org/wiki/Q1897162', 'display_name': 'Parasitemia', 'level': 4, 'score': 0.8596519}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.769711}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.7627614}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.68209267}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.50118685}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.47466186}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.32770592}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.30481046}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19412735}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.066204995}], 'mesh': [{'descriptor_ui': 'D000655', 'descriptor_name': 'Amodiaquine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000655', 'descriptor_name': 'Amodiaquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000655', 'descriptor_name': 'Amodiaquine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001682', 'descriptor_name': 'Biological Availability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002738', 'descriptor_name': 'Chloroquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004352', 'descriptor_name': 'Drug Resistance, Microbial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010679', 'descriptor_name': 'Philippines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.1987.36.3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3544892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.85, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3129754961', 'https://openalex.org/W3035397081', 'https://openalex.org/W2406164295', 'https://openalex.org/W2288094449', 'https://openalex.org/W2144038468', 'https://openalex.org/W2093960865', 'https://openalex.org/W2031620658', 'https://openalex.org/W1998795420', 'https://openalex.org/W1848139203', 'https://openalex.org/W1587738737'], 'abstract_inverted_index': {'Amodiaquine': [0], 'was': [1, 58, 67, 79, 120], 'compared': [2], 'to': [3, 50, 106, 118, 126], 'chloroquine': [4, 35, 127, 146], 'in': [5, 54, 84, 91, 111, 147], 'two': [6], 'groups': [7], 'of': [8, 20, 44, 82, 100, 140, 150], 'Filipino': [9], 'patients': [10, 33, 46, 56, 94], 'with': [11], 'uncomplicated': [12], 'falciparum': [13, 102, 152], 'malaria.': [14], 'Every': [15], 'patient': [16], 'received': [17], '25': [18], 'mg/kg': [19], 'base': [21], 'orally': [22], 'given': [23], 'over': [24], 'three': [25], 'days.': [26], 'In': [27, 73, 114], 'a': [28, 74], 'hospital': [29], 'study,': [30, 77], 'all': [31, 62, 92], 'eight': [32, 45], 'receiving': [34, 47, 95], 'cleared': [36], 'their': [37], 'parasitemia': [38, 52, 83, 109], 'by': [39], 'day': [40], '6,': [41], 'but': [42], 'six': [43, 101], 'amodiaquine': [48, 96, 119, 141], 'failed': [49], 'clear': [51], 'and': [53], 'four': [55], 'there': [57, 78], 'no': [59], 'response': [60], 'at': [61], '(RIII': [63], 'resistance);': [64], 'this': [65, 115, 135], 'difference': [66], 'significant': [68], '(P': [69, 128], 'less': [70, 129], 'than': [71, 124, 130, 145], '0.01).': [72], 'village': [75], 'based': [76], 'initial': [80], 'clearing': [81], 'each': [85], 'patient.': [86, 113], 'However,': [87], 'recrudescent': [88], 'infection': [89], 'occurred': [90], 'five': [93], '(RI': [97], 'resistance).': [98], 'Five': [99], 'infections': [103], 'were': [104], 'sensitive': [105], 'chloroquine,': [107], 'while': [108], 'reappeared': [110], 'one': [112], 'village,': [116], 'resistance': [117, 125], 'significantly': [121], 'more': [122], 'common': [123], '0.05).': [131], 'To': [132], 'our': [133], 'knowledge,': [134], 'is': [136], 'the': [137, 148], 'first': [138], 'report': [139], 'being': [142], 'substantially': [143], 'worse': [144], 'treatment': [149], 'Plasmodium': [151], 'infection.': [153]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2470168894', 'counts_by_year': [], 'updated_date': '2024-12-08T20:48:42.696179', 'created_date': '2016-07-22'}