Publication Information

{'id': 'https://openalex.org/W2560580707', 'doi': 'https://doi.org/10.1002/ijc.30556', 'title': 'A 16 Yin Yang gene expression ratio signature for ER+/node− breast cancer', 'display_name': 'A 16 Yin Yang gene expression ratio signature for ER+/node− breast cancer', 'publication_year': 2016, 'publication_date': '2016-12-07', 'ids': {'openalex': 'https://openalex.org/W2560580707', 'doi': 'https://doi.org/10.1002/ijc.30556', 'mag': '2560580707', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27925180'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ijc.30556', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.30556', 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.30556', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039548719', 'display_name': 'Wayne Wenzhong Xu', 'orcid': 'https://orcid.org/0000-0003-0484-7340'}, 'institutions': [{'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210166742', 'display_name': 'Research Institute in Oncology and Hematology', 'ror': 'https://ror.org/05qer3y84', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088414', 'https://openalex.org/I4210166742', 'https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210088414', 'display_name': 'CancerCare Manitoba', 'ror': 'https://ror.org/005cmms77', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088414']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Wayne Xu', 'raw_affiliation_strings': ['College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB'], 'affiliations': [{'raw_affiliation_string': 'College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I46247651']}, {'raw_affiliation_string': 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210166742', 'https://openalex.org/I4210088414']}, {'raw_affiliation_string': 'Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113964500', 'display_name': 'Gaofeng Jia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166742', 'display_name': 'Research Institute in Oncology and Hematology', 'ror': 'https://ror.org/05qer3y84', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088414', 'https://openalex.org/I4210166742', 'https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210088414', 'display_name': 'CancerCare Manitoba', 'ror': 'https://ror.org/005cmms77', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088414']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Gaofeng Jia', 'raw_affiliation_strings': ['Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210166742', 'https://openalex.org/I4210088414']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046138270', 'display_name': 'Nianguang Cai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166742', 'display_name': 'Research Institute in Oncology and Hematology', 'ror': 'https://ror.org/05qer3y84', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088414', 'https://openalex.org/I4210166742', 'https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210088414', 'display_name': 'CancerCare Manitoba', 'ror': 'https://ror.org/005cmms77', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088414']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Nianguang Cai', 'raw_affiliation_strings': ['Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210166742', 'https://openalex.org/I4210088414']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087634069', 'display_name': 'Shujun Huang', 'orcid': 'https://orcid.org/0000-0002-6994-1875'}, 'institutions': [{'id': 'https://openalex.org/I4210166742', 'display_name': 'Research Institute in Oncology and Hematology', 'ror': 'https://ror.org/05qer3y84', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088414', 'https://openalex.org/I4210166742', 'https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210088414', 'display_name': 'CancerCare Manitoba', 'ror': 'https://ror.org/005cmms77', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088414']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Shujun Huang', 'raw_affiliation_strings': ['College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210166742', 'https://openalex.org/I4210088414']}, {'raw_affiliation_string': 'College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048849645', 'display_name': 'James Davie', 'orcid': 'https://orcid.org/0000-0002-0420-6888'}, 'institutions': [{'id': 'https://openalex.org/I4210166742', 'display_name': 'Research Institute in Oncology and Hematology', 'ror': 'https://ror.org/05qer3y84', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088414', 'https://openalex.org/I4210166742', 'https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210088414', 'display_name': 'CancerCare Manitoba', 'ror': 'https://ror.org/005cmms77', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088414']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'James R. Davie', 'raw_affiliation_strings': ['Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210166742', 'https://openalex.org/I4210088414']}, {'raw_affiliation_string': 'Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I46247651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037906439', 'display_name': 'Marshall Pitz', 'orcid': 'https://orcid.org/0000-0002-1858-5081'}, 'institutions': [{'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210166742', 'display_name': 'Research Institute in Oncology and Hematology', 'ror': 'https://ror.org/05qer3y84', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088414', 'https://openalex.org/I4210166742', 'https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210088414', 'display_name': 'CancerCare Manitoba', 'ror': 'https://ror.org/005cmms77', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088414']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Marshall Pitz', 'raw_affiliation_strings': ['Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I46247651']}, {'raw_affiliation_string': 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210166742', 'https://openalex.org/I4210088414']}, {'raw_affiliation_string': 'Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210088414']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041999731', 'display_name': 'Shantanu Banerji', 'orcid': 'https://orcid.org/0000-0002-7531-1378'}, 'institutions': [{'id': 'https://openalex.org/I4210088414', 'display_name': 'CancerCare Manitoba', 'ror': 'https://ror.org/005cmms77', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088414']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210166742', 'display_name': 'Research Institute in Oncology and Hematology', 'ror': 'https://ror.org/05qer3y84', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088414', 'https://openalex.org/I4210166742', 'https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Shantanu Banerji', 'raw_affiliation_strings': ['Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210088414']}, {'raw_affiliation_string': 'Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I46247651']}, {'raw_affiliation_string': 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210166742', 'https://openalex.org/I4210088414']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051115945', 'display_name': 'Leigh C. Murphy', 'orcid': 'https://orcid.org/0000-0002-7676-6032'}, 'institutions': [{'id': 'https://openalex.org/I4210166742', 'display_name': 'Research Institute in Oncology and Hematology', 'ror': 'https://ror.org/05qer3y84', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210088414', 'https://openalex.org/I4210166742', 'https://openalex.org/I46247651']}, {'id': 'https://openalex.org/I4210088414', 'display_name': 'CancerCare Manitoba', 'ror': 'https://ror.org/005cmms77', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088414']}, {'id': 'https://openalex.org/I46247651', 'display_name': 'University of Manitoba', 'ror': 'https://ror.org/02gfys938', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I46247651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Leigh Murphy', 'raw_affiliation_strings': ['Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I4210166742', 'https://openalex.org/I4210088414']}, {'raw_affiliation_string': 'Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB', 'institution_ids': ['https://openalex.org/I46247651']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5039548719'], 'corresponding_institution_ids': ['https://openalex.org/I46247651', 'https://openalex.org/I4210166742', 'https://openalex.org/I4210088414'], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.538, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.585848, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 85}, 'biblio': {'volume': '140', 'issue': '6', 'first_page': '1413', 'last_page': '1424'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10183', 'display_name': 'Breast Cancer Treatment Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10183', 'display_name': 'Breast Cancer Treatment Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9885, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/signature', 'display_name': 'Signature (topology)', 'score': 0.4398256}, {'id': 'https://openalex.org/keywords/gene-signature', 'display_name': 'Gene signature', 'score': 0.42612126}], 'concepts': [{'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.72452724}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.51289415}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.50698566}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5067583}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.441143}, {'id': 'https://openalex.org/C2779696439', 'wikidata': 'https://www.wikidata.org/wiki/Q7512811', 'display_name': 'Signature (topology)', 'level': 2, 'score': 0.4398256}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43434742}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43316758}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4272273}, {'id': 'https://openalex.org/C2779733811', 'wikidata': 'https://www.wikidata.org/wiki/Q5531562', 'display_name': 'Gene signature', 'level': 4, 'score': 0.42612126}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4101969}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.35989523}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.32666928}, {'id': 'https://openalex.org/C29456083', 'wikidata': 'https://www.wikidata.org/wiki/Q1221899', 'display_name': 'Gynecology', 'level': 1, 'score': 0.32457298}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.112460375}, {'id': 'https://openalex.org/C2524010', 'wikidata': 'https://www.wikidata.org/wiki/Q8087', 'display_name': 'Geometry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004967', 'descriptor_name': 'Estrogens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D052138', 'descriptor_name': 'Genes, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D059467', 'descriptor_name': 'Transcriptome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D001940', 'descriptor_name': 'Breast', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001940', 'descriptor_name': 'Breast', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066264', 'descriptor_name': 'Datasets as Topic', 'qualifier_ui': 'Q000706', 'qualifier_name': 'statistics & numerical data', 'is_major_topic': False}, {'descriptor_ui': 'D066264', 'descriptor_name': 'Datasets as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009376', 'descriptor_name': 'Neoplasms, Hormone-Dependent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016016', 'descriptor_name': 'Proportional Hazards Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016709', 'descriptor_name': 'Yin-Yang', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ijc.30556', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.30556', 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27925180', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/ijc.30556', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.30556', 'source': {'id': 'https://openalex.org/S5382288', 'display_name': 'International Journal of Cancer', 'issn_l': '0020-7136', 'issn': ['0020-7136', '1097-0215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.65, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1966903330', 'https://openalex.org/W1971177781', 'https://openalex.org/W1997479509', 'https://openalex.org/W1999574084', 'https://openalex.org/W2003214099', 'https://openalex.org/W2003421056', 'https://openalex.org/W2005895632', 'https://openalex.org/W2015833571', 'https://openalex.org/W2017536128', 'https://openalex.org/W2022397091', 'https://openalex.org/W2033691422', 'https://openalex.org/W2040761353', 'https://openalex.org/W2042954782', 'https://openalex.org/W2045480092', 'https://openalex.org/W2045718557', 'https://openalex.org/W2050256263', 'https://openalex.org/W2054270840', 'https://openalex.org/W2057907408', 'https://openalex.org/W2070486022', 'https://openalex.org/W2074465378', 'https://openalex.org/W2102486244', 'https://openalex.org/W2105882193', 'https://openalex.org/W2107160082', 'https://openalex.org/W2122673439', 'https://openalex.org/W2123434562', 'https://openalex.org/W2128360321', 'https://openalex.org/W2128767954', 'https://openalex.org/W2128985829', 'https://openalex.org/W2132619562', 'https://openalex.org/W2136833945', 'https://openalex.org/W2140628034', 'https://openalex.org/W2141630969', 'https://openalex.org/W2150073419', 'https://openalex.org/W2152512826', 'https://openalex.org/W2155177044', 'https://openalex.org/W2157132621', 'https://openalex.org/W2159391802', 'https://openalex.org/W2161109798', 'https://openalex.org/W2163563958', 'https://openalex.org/W2165038925', 'https://openalex.org/W2167249782', 'https://openalex.org/W2167925037', 'https://openalex.org/W2168233149', 'https://openalex.org/W2169488765', 'https://openalex.org/W2491258584', 'https://openalex.org/W4245024447'], 'related_works': ['https://openalex.org/W4301030387', 'https://openalex.org/W3030774134', 'https://openalex.org/W2535275505', 'https://openalex.org/W2375584271', 'https://openalex.org/W2168674042', 'https://openalex.org/W2104499293', 'https://openalex.org/W2082057679', 'https://openalex.org/W1997105855', 'https://openalex.org/W1971594271', 'https://openalex.org/W1671124163'], 'abstract_inverted_index': {'Breast': [0], 'cancer': [1, 9, 69, 121], 'is': [2, 14, 173], 'one': [3], 'of': [4, 8, 45, 66, 119, 137, 167, 238], 'the': [5, 58, 108, 131, 176], 'leading': [6], 'causes': [7], 'death': [10], 'in': [11, 105, 191], 'women.': [12], 'It': [13], 'a': [15, 52, 231, 236], 'complex': [16], 'and': [17, 48, 95, 97, 141, 217], 'heterogeneous': [18], 'disease': [19], 'with': [20, 28, 75, 91], 'different': [21, 29, 148], 'clinical': [22, 34, 232], 'outcomes.': [23], 'Stratifying': [24], 'patients': [25, 70, 79, 87, 122, 145, 172, 241], 'into': [26, 71], 'subgroups': [27], 'outcomes': [30], 'could': [31], 'help': [32], 'guide': [33], 'decision': [35], 'making.': [36], 'In': [37], 'this': [38], 'study,': [39], 'we': [40, 61], 'used': [41], 'two': [42], 'opposing': [43], 'groups': [44, 99], 'genes,': [46], 'Yin': [47], 'Yang,': [49], 'to': [50, 107, 175, 234], 'develop': [51], 'prognostic': [53], 'expression': [54], 'ratio': [55], 'signature.': [56], 'Using': [57], 'METABRIC': [59], 'cohort': [60], 'identified': [62], 'a16-gene': [63], 'signature': [64, 113, 226], 'capable': [65], 'stratifying': [67, 192], 'breast': [68, 120], 'four': [72, 115], 'risk': [73, 116], 'levels': [74], 'intention': [76], 'that': [77], 'low-risk': [78, 132, 239], 'would': [80], 'not': [81, 152, 244], 'undergo': [82], 'adjuvant': [83, 156, 247], 'systemic': [84, 155], 'therapy,': [85], 'intermediate-low-risk': [86], 'will': [88, 100], 'be': [89, 101, 228], 'treated': [90, 102], 'hormonal': [92, 109, 248], 'therapy': [93, 157, 249], 'only,': [94], 'intermediate-high-': [96], 'high-risk': [98], 'by': [103], 'chemotherapy': [104], 'addition': [106], 'therapy.': [110], 'The': [111, 164], '16-gene': [112], 'for': [114, 169], 'level': [117], 'stratifications': [118], 'has': [123], 'been': [124], 'validated': [125], 'using': [126], '14': [127], 'independent': [128], 'datasets.': [129], 'Notably,': [130], 'group': [133], '(n': [134], '=': [135, 186, 189, 198, 201, 205, 208, 212, 215, 220, 223], '51)': [136], '205': [138], 'estrogen': [139], 'receptor-positive': [140], 'node': [142], 'negative': [143, 171], '(ER+/node−)': [144], 'from': [146], 'three': [147], 'datasets': [149], 'who': [150, 242], 'had': [151, 153, 158], 'any': [154, 246], '100%': [159], '15-year': [160], 'disease-specific': [161], 'survival': [162], 'rate.': [163], 'Concordance': [165], 'Index': [166], 'YMR': [168, 181, 225], 'ER+/node': [170], 'close': [174], 'commercially': [177], 'available': [178], 'signatures.': [179], 'However,': [180], 'showed': [182], 'more': [183], 'significance': [184], '(HR': [185, 197, 204, 211, 219], '3.7,': [187], 'p': [188, 200, 207, 214, 222], '8.7e-12)': [190], 'ER+/node−': [193, 240], 'subgroup': [194, 237], 'than': [195], 'OncotypeDx': [196], '2.7,': [199], '1.3e-7),': [202], 'MammaPrint': [203], '2.5,': [206], '5.8e-7),': [209], 'rorS': [210], '2.4,': [213], '1.4e-6),': [216], 'NPI': [218], '2.6,': [221], '1.2e-6).': [224], 'may': [227], 'developed': [229], 'as': [230], 'tool': [233], 'select': [235], 'do': [243], 'require': [245], '(AHT).': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2560580707', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2024-12-18T05:52:15.120798', 'created_date': '2016-12-16'}