Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2552239346', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-364', 'title': 'Abstract 364: The molecular profiles of disseminated tumor cells in a Patient Derived Xenograft model recapitulate those found in patient bone marrow', 'display_name': 'Abstract 364: The molecular profiles of disseminated tumor cells in a Patient Derived Xenograft model recapitulate those found in patient bone marrow', 'publication_year': 2015, 'publication_date': '2015-08-01', 'ids': {'openalex': 'https://openalex.org/W2552239346', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-364', 'mag': '2552239346'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-364', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102019130', 'display_name': 'Sreeraj G. Pillai', 'orcid': 'https://orcid.org/0000-0002-0285-0813'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sreeraj G. Pillai', 'raw_affiliation_strings': ['Washington University, St. Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University, St. Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034234418', 'display_name': 'Shunqiang Li', 'orcid': 'https://orcid.org/0000-0001-9508-7249'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shunqiang Li', 'raw_affiliation_strings': ['Washington University, St. Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University, St. Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004954876', 'display_name': 'Chidananda Mudalagiriyappa', 'orcid': 'https://orcid.org/0000-0002-6942-6793'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chidananda M. Siddappa', 'raw_affiliation_strings': ['Washington University, St. Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University, St. Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007830810', 'display_name': 'Mark A. Watson', 'orcid': 'https://orcid.org/0000-0002-3935-9980'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark A. Watson', 'raw_affiliation_strings': ['Washington University, St. Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University, St. Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008456176', 'display_name': 'Timothy P. Fleming', 'orcid': 'https://orcid.org/0000-0002-8661-1210'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Timothy P. Fleming', 'raw_affiliation_strings': ['Washington University, St. Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University, St. Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057135409', 'display_name': 'Matthew J. Ellis', 'orcid': 'https://orcid.org/0000-0002-8467-8534'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew J. Ellis', 'raw_affiliation_strings': ['Washington University, St. Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University, St. Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054757298', 'display_name': 'Rebecca Aft', 'orcid': 'https://orcid.org/0000-0001-8569-7131'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rebecca L. Aft', 'raw_affiliation_strings': ['Washington University, St. Louis, MO.'], 'affiliations': [{'raw_affiliation_string': 'Washington University, St. Louis, MO.', 'institution_ids': ['https://openalex.org/I204465549']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.464598, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '75', 'issue': '15_Supplement', 'first_page': '364', 'last_page': '364'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9811, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9811, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9528, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9226, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6799402}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.6782913}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.6421553}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.5226807}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.49576053}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48422265}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.43156594}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25733584}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-364', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.72, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3196332669', 'https://openalex.org/W3030988181', 'https://openalex.org/W2418638721', 'https://openalex.org/W2393474572', 'https://openalex.org/W2366529083', 'https://openalex.org/W2365364931', 'https://openalex.org/W2091020218', 'https://openalex.org/W2027717767', 'https://openalex.org/W1970614368', 'https://openalex.org/W1572485201'], 'abstract_inverted_index': {'Abstract': [0], 'Objective': [1], 'Disseminated': [2], 'tumor': [3, 152, 398], 'cells': [4, 399], '(DTCs)': [5], 'found': [6, 257, 408], 'in': [7, 27, 191, 205, 215, 242, 260, 292, 301, 312, 329, 400, 409], 'the': [8, 28, 38, 48, 97, 107, 128, 156, 206, 243, 252, 261, 302, 313, 324, 330, 344, 417, 422], 'bone': [9, 411], 'marrow': [10], '(BM)': [11], 'of': [12, 50, 106, 143, 158, 160, 180, 200, 208, 217, 232, 245, 263, 299, 327, 332, 396, 416, 421], 'breast': [13, 68, 138, 209, 266, 335], 'cancer': [14, 139, 210, 267, 336], 'patients': [15, 75, 140, 211, 268, 280, 337], 'portends': [16], 'a': [17, 348, 401], 'poor': [18], 'prognosis.': [19], 'BM': [20, 93, 147, 183, 193, 207, 216, 244, 262, 303, 331], 'DTCs': [21, 54, 159, 300, 328], 'are': [22, 221], 'thought': [23], 'to': [24, 58, 195, 270, 278, 354], 'be': [25], 'intermediaries': [26], 'metastatic': [29, 165, 176, 249, 275, 285, 308], 'process': [30], 'and': [31, 55, 82, 99, 109, 141, 228, 239, 288, 304], 'may': [32], 'exhibit': [33], 'molecular': [34, 394], 'features': [35], 'different': [36], 'from': [37, 73, 96, 101, 130, 150, 170], 'primary': [39], 'tumor.': [40], 'Using': [41], 'Patient': [42, 402], 'Derived': [43, 403], 'Xenograft': [44, 404], 'system,': [45, 361], 'we': [46, 256, 362], 'report': [47], 'presence': [49, 157, 231, 298], 'transcript': [51], 'associated': [52, 368], 'with': [53, 76, 307, 338, 369], 'their': [56, 192], 'correlation': [57], 'distant': [59], 'disease': [60, 340], 'development.': [61, 341], 'Experimental': [62], 'procedures': [63], 'After': [64], 'informed': [65], 'consent,': [66], 'human': [67], 'adenocarcinomas': [69], 'were': [70, 203, 290], 'prospectively': [71], 'collected': [72, 95], '5': [74], 'estrogen': [77], 'receptor': [78], 'negative/Her2': [79], 'negative': [80], 'tumors': [81, 108, 276], 'implanted': [83], 'into': [84], 'NOD/SCID': [85], 'mouse': [86], 'mammary': [87], 'fat': [88], 'pad': [89], 'as': [90], 'previous': [91], 'described.': [92], 'was': [94, 125, 148, 235, 240, 310], 'femur': [98], 'tibia': [100], 'mice': [102, 154, 163, 168, 246, 346], 'at': [103], 'varying': [104], 'passages': [105], 'analyzed': [110], 'for': [111, 155, 323, 425], 'human-specific': [112], 'transcripts': [113, 234], 'by': [114, 237], 'qRT-PCR.': [115], 'Human': [116, 122], 'gene': [117, 123], 'expression': [118], 'array': [119], 'analysis': [120], '(Affymetrix': [121], '1.0ST)': [124], 'performed': [126], 'on': [127], 'BMs': [129], 'all': [131, 293], 'WHIM17': [132, 294], 'mice,': [133, 137], 'control': [134], 'non-tumor': [135, 196], 'bearing': [136, 153, 197], 'that': [142], 'healthy': [144, 218], 'volunteers.': [145, 219], 'Results': [146], 'screened': [149], '18': [151], 'which': [161, 247, 255], '10': [162, 189], 'developed': [164, 169, 175, 248, 274], 'tumors.': [166, 177, 250], 'All': [167], 'one': [171], 'patient': [172, 410], 'line': [173], '(WHIM17)': [174], 'Further': [178], 'microanalysis': [179], 'WHIM': [181], '17': [182], 'showed': [184], '300': [185], 'genes': [186, 202, 254, 367], 'upregulated': [187, 259, 291], 'over': [188], 'fold': [190], 'compared': [194, 277, 353], 'mice.': [198, 295], '7': [199], 'these': [201, 233], 'detected': [204, 241], 'but': [212], 'completely': [213], 'absent': [214], 'They': [220], 'TNFRSF17,': [222], 'CD226,': [223], 'HIST1H4E,': [224], 'MDM2,': [225], 'TFAM,': [226], 'DDT,': [227], 'RPS20.': [229], 'The': [230, 297, 393], 'confirmed': [236], 'qRT-PCR': [238], 'Of': [251], '32': [253], 'significantly': [258], 'stage': [264, 334], 'II/III': [265], 'prior': [269], 'treatment': [271], 'who': [272, 281], 'subsequently': [273], 'similar': [279], 'did': [282], 'not': [283], 'develop': [284], 'disease,': [286], 'DCSR3': [287], 'STAM2': [289], 'Conclusion': [296], 'its': [305], 'association': [306, 326], 'outcome': [309], 'observed': [311], 'PDX': [314, 345], 'model': [315, 352, 405], 'system.': [316], 'Our': [317], 'results': [318], 'provide': [319], 'an': [320], 'experimental': [321], 'support': [322], 'clinical': [325], 'early': [333], 'recurrent': [339], 'We': [342], 'believe': [343], 'recreate': [347], 'more': [349], 'clinically': [350], 'relevant': [351], 'other': [355], 'xenograft': [356], 'models.': [357], 'Moreover,': [358], 'using': [359], 'this': [360], 'have': [363], 'identified': [364], 'new': [365], 'targetable': [366], 'DTCS.': [370], 'Citation': [371], 'Format:': [372], 'Sreeraj': [373], 'G.': [374], 'Pillai,': [375], 'Shunqiang': [376], 'Li,': [377], 'Chidananda': [378], 'M.': [379], 'Siddappa,': [380], 'Mark': [381], 'A.': [382], 'Watson,': [383], 'Timothy': [384], 'P.': [385], 'Fleming,': [386], 'Matthew': [387], 'J.': [388], 'Ellis,': [389], 'Rebecca': [390], 'L.': [391], 'Aft.': [392], 'profiles': [395], 'disseminated': [397], 'recapitulate': [406], 'those': [407], 'marrow.': [412], '[abstract].': [413], 'In:': [414], 'Proceedings': [415], '106th': [418], 'Annual': [419], 'Meeting': [420], 'American': [423], 'Association': [424], 'Cancer': [426, 436], 'Research;': [427], '2015': [428], 'Apr': [429], '18-22;': [430], 'Philadelphia,': [431], 'PA.': [432], 'Philadelphia': [433], '(PA):': [434], 'AACR;': [435], 'Res': [437], '2015;75(15': [438], 'Suppl):Abstract': [439], 'nr': [440], '364.': [441], 'doi:10.1158/1538-7445.AM2015-364': [442]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2552239346', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-12T01:22:21.390794', 'created_date': '2016-11-30'}