Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential

Name: Work Video:
Duration: 3 min 30 s
Joshua Bloom; Christine N. Metz; Saisha Nalawade; Julian Casabar; Kai Cheng; Mingzhu He; Barbara Sherry; Thomas R. Coleman; Thomas G. Forsthuber; Yousef Al‐Abed
{'id': 'https://openalex.org/W2540884398', 'doi': 'https://doi.org/10.1074/jbc.m116.743328', 'title': 'Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential', 'display_name': 'Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential', 'publication_year': 2016, 'publication_date': '2016-10-29', 'ids': {'openalex': 'https://openalex.org/W2540884398', 'doi': 'https://doi.org/10.1074/jbc.m116.743328', 'mag': '2540884398', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27793992', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5159510'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m116.743328', 'pdf_url': 'http://www.jbc.org/article/S0021925820344707/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820344707/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040517767', 'display_name': 'Joshua Bloom', 'orcid': 'https://orcid.org/0000-0001-7654-7828'}, 'institutions': [{'id': 'https://openalex.org/I139290212', 'display_name': 'Hofstra University', 'ror': 'https://ror.org/03pm18j10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I139290212']}, {'id': 'https://openalex.org/I4210124306', 'display_name': 'The Centers', 'ror': 'https://ror.org/033tgbx59', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210124306']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Joshua Bloom', 'raw_affiliation_strings': ['From the Hofstra-Northwell School of Medicine, Hempstead, New York 11549,', 'the Centers for Molecular Innovation,'], 'affiliations': [{'raw_affiliation_string': 'From the Hofstra-Northwell School of Medicine, Hempstead, New York 11549,', 'institution_ids': ['https://openalex.org/I139290212']}, {'raw_affiliation_string': 'the Centers for Molecular Innovation,', 'institution_ids': ['https://openalex.org/I4210124306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065787721', 'display_name': 'Christine N. Metz', 'orcid': 'https://orcid.org/0000-0002-1013-1691'}, 'institutions': [{'id': 'https://openalex.org/I139290212', 'display_name': 'Hofstra University', 'ror': 'https://ror.org/03pm18j10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I139290212']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine Metz', 'raw_affiliation_strings': ['Biomedical Sciences', 'From the Hofstra-Northwell School of Medicine, Hempstead, New York 11549,'], 'affiliations': [{'raw_affiliation_string': 'Biomedical Sciences', 'institution_ids': []}, {'raw_affiliation_string': 'From the Hofstra-Northwell School of Medicine, Hempstead, New York 11549,', 'institution_ids': ['https://openalex.org/I139290212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084568729', 'display_name': 'Saisha Nalawade', 'orcid': 'https://orcid.org/0000-0002-4048-632X'}, 'institutions': [{'id': 'https://openalex.org/I45438204', 'display_name': 'The University of Texas at San Antonio', 'ror': 'https://ror.org/01kd65564', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I45438204']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Saisha Nalawade', 'raw_affiliation_strings': ['the Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249'], 'affiliations': [{'raw_affiliation_string': 'the Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249', 'institution_ids': ['https://openalex.org/I45438204']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071648955', 'display_name': 'Julian Casabar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45438204', 'display_name': 'The University of Texas at San Antonio', 'ror': 'https://ror.org/01kd65564', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I45438204']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julian Casabar', 'raw_affiliation_strings': ['the Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249'], 'affiliations': [{'raw_affiliation_string': 'the Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249', 'institution_ids': ['https://openalex.org/I45438204']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008522740', 'display_name': 'Kai Cheng', 'orcid': 'https://orcid.org/0000-0002-6045-0244'}, 'institutions': [{'id': 'https://openalex.org/I4210124306', 'display_name': 'The Centers', 'ror': 'https://ror.org/033tgbx59', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210124306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kai Fan Cheng', 'raw_affiliation_strings': ['the Centers for Molecular Innovation,'], 'affiliations': [{'raw_affiliation_string': 'the Centers for Molecular Innovation,', 'institution_ids': ['https://openalex.org/I4210124306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007010287', 'display_name': 'Mingzhu He', 'orcid': 'https://orcid.org/0000-0001-7779-2411'}, 'institutions': [{'id': 'https://openalex.org/I4210124306', 'display_name': 'The Centers', 'ror': 'https://ror.org/033tgbx59', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210124306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mingzhu He', 'raw_affiliation_strings': ['the Centers for Molecular Innovation,'], 'affiliations': [{'raw_affiliation_string': 'the Centers for Molecular Innovation,', 'institution_ids': ['https://openalex.org/I4210124306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036625600', 'display_name': 'Barbara Sherry', 'orcid': 'https://orcid.org/0000-0003-3119-1463'}, 'institutions': [{'id': 'https://openalex.org/I4210095197', 'display_name': 'Institut thématique Immunologie, inflammation, infectiologie et microbiologie', 'ror': 'https://ror.org/00r454w59', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210095197']}, {'id': 'https://openalex.org/I139290212', 'display_name': 'Hofstra University', 'ror': 'https://ror.org/03pm18j10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I139290212']}], 'countries': ['FR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Barbara Sherry', 'raw_affiliation_strings': ['From the Hofstra-Northwell School of Medicine, Hempstead, New York 11549,', 'Immunology and Inflammation'], 'affiliations': [{'raw_affiliation_string': 'Immunology and Inflammation', 'institution_ids': ['https://openalex.org/I4210095197']}, {'raw_affiliation_string': 'From the Hofstra-Northwell School of Medicine, Hempstead, New York 11549,', 'institution_ids': ['https://openalex.org/I139290212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076233609', 'display_name': 'Thomas R. Coleman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1327576362', 'display_name': 'Feinstein Institute for Medical Research', 'ror': 'https://ror.org/05dnene97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1302444339', 'https://openalex.org/I1327576362']}, {'id': 'https://openalex.org/I2799708222', 'display_name': 'Office of Technology Transfer', 'ror': 'https://ror.org/031gy6182', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I2799708222', 'https://openalex.org/I4210091794']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas Coleman', 'raw_affiliation_strings': ['the Office of Technology Transfer, The Feinstein Institute for Medical Research, Manhasset, New York 11030'], 'affiliations': [{'raw_affiliation_string': 'the Office of Technology Transfer, The Feinstein Institute for Medical Research, Manhasset, New York 11030', 'institution_ids': ['https://openalex.org/I1327576362', 'https://openalex.org/I2799708222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008482088', 'display_name': 'Thomas G. Forsthuber', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45438204', 'display_name': 'The University of Texas at San Antonio', 'ror': 'https://ror.org/01kd65564', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I45438204']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas Forsthuber', 'raw_affiliation_strings': ['the Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249'], 'affiliations': [{'raw_affiliation_string': 'the Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249', 'institution_ids': ['https://openalex.org/I45438204']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078561745', 'display_name': 'Yousef Al‐Abed', 'orcid': 'https://orcid.org/0000-0001-5478-0506'}, 'institutions': [{'id': 'https://openalex.org/I139290212', 'display_name': 'Hofstra University', 'ror': 'https://ror.org/03pm18j10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I139290212']}, {'id': 'https://openalex.org/I4210124306', 'display_name': 'The Centers', 'ror': 'https://ror.org/033tgbx59', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210124306']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yousef Al-Abed', 'raw_affiliation_strings': ['From the Hofstra-Northwell School of Medicine, Hempstead, New York 11549,', 'the Centers for Molecular Innovation,'], 'affiliations': [{'raw_affiliation_string': 'From the Hofstra-Northwell School of Medicine, Hempstead, New York 11549,', 'institution_ids': ['https://openalex.org/I139290212']}, {'raw_affiliation_string': 'the Centers for Molecular Innovation,', 'institution_ids': ['https://openalex.org/I4210124306']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5040517767', 'https://openalex.org/A5078561745'], 'corresponding_institution_ids': ['https://openalex.org/I139290212', 'https://openalex.org/I4210124306', 'https://openalex.org/I139290212', 'https://openalex.org/I4210124306'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.663, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 56, 'citation_normalized_percentile': {'value': 0.8425, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '291', 'issue': '51', 'first_page': '26502', 'last_page': '26514'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13254', 'display_name': 'Macrophage Migration Inhibitory Factor', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13254', 'display_name': 'Macrophage Migration Inhibitory Factor', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9343, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd74', 'display_name': 'CD74', 'score': 0.5011265}, {'id': 'https://openalex.org/keywords/drug-repositioning', 'display_name': 'Drug repositioning', 'score': 0.44096854}], 'concepts': [{'id': 'https://openalex.org/C104177226', 'wikidata': 'https://www.wikidata.org/wiki/Q15311903', 'display_name': 'Macrophage migration inhibitory factor', 'level': 3, 'score': 0.96144193}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.5833621}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.53130674}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.50185657}, {'id': 'https://openalex.org/C119997001', 'wikidata': 'https://www.wikidata.org/wiki/Q21113110', 'display_name': 'CD74', 'level': 5, 'score': 0.5011265}, {'id': 'https://openalex.org/C16613235', 'wikidata': 'https://www.wikidata.org/wiki/Q285982', 'display_name': 'Endogeny', 'level': 2, 'score': 0.48940578}, {'id': 'https://openalex.org/C103637391', 'wikidata': 'https://www.wikidata.org/wiki/Q5308921', 'display_name': 'Drug repositioning', 'level': 3, 'score': 0.44096854}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.41751826}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.39796904}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.34297997}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34114808}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.31539327}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1529161}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.09455407}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.058963537}, {'id': 'https://openalex.org/C2778814158', 'wikidata': 'https://www.wikidata.org/wiki/Q959350', 'display_name': 'MHC class II', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m116.743328', 'pdf_url': 'http://www.jbc.org/article/S0021925820344707/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5159510', 'pdf_url': 'https://europepmc.org/articles/pmc5159510?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159510', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m116.743328', 'pdf_url': 'http://www.jbc.org/article/S0021925820344707/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.67, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320309030', 'funder_display_name': 'Small Business Innovation Research', 'award_id': '1R43AR062401'}, {'funder': 'https://openalex.org/F4320337355', 'funder_display_name': 'National Institute of Allergy and Infectious Diseases', 'award_id': 'R21AI110771'}], 'datasets': [], 'versions': [], 'referenced_works_count': 108, 'referenced_works': ['https://openalex.org/W109149868', 'https://openalex.org/W1486948645', 'https://openalex.org/W1512672058', 'https://openalex.org/W1523338791', 'https://openalex.org/W1577799117', 'https://openalex.org/W1629956987', 'https://openalex.org/W1817885483', 'https://openalex.org/W1868273134', 'https://openalex.org/W1874492336', 'https://openalex.org/W1961305233', 'https://openalex.org/W1963774897', 'https://openalex.org/W1964066906', 'https://openalex.org/W1970596902', 'https://openalex.org/W1971238085', 'https://openalex.org/W1972602089', 'https://openalex.org/W1976282578', 'https://openalex.org/W1977017849', 'https://openalex.org/W1980506947', 'https://openalex.org/W1986837253', 'https://openalex.org/W1989832114', 'https://openalex.org/W1990586585', 'https://openalex.org/W1991922050', 'https://openalex.org/W2001634895', 'https://openalex.org/W2002902649', 'https://openalex.org/W2004202496', 'https://openalex.org/W2005488007', 'https://openalex.org/W2010189440', 'https://openalex.org/W2013282142', 'https://openalex.org/W2023837865', 'https://openalex.org/W2027689653', 'https://openalex.org/W2027778269', 'https://openalex.org/W2028773046', 'https://openalex.org/W2029174607', 'https://openalex.org/W2032686039', 'https://openalex.org/W2033808144', 'https://openalex.org/W2035352223', 'https://openalex.org/W2037750523', 'https://openalex.org/W2040336985', 'https://openalex.org/W2042722349', 'https://openalex.org/W2043703663', 'https://openalex.org/W2046055623', 'https://openalex.org/W2046525356', 'https://openalex.org/W2049310294', 'https://openalex.org/W2051229259', 'https://openalex.org/W2052019729', 'https://openalex.org/W2060550312', 'https://openalex.org/W2062383948', 'https://openalex.org/W2066027939', 'https://openalex.org/W2067583186', 'https://openalex.org/W2068579674', 'https://openalex.org/W2069067064', 'https://openalex.org/W2069239740', 'https://openalex.org/W2073282846', 'https://openalex.org/W2077056196', 'https://openalex.org/W2077753096', 'https://openalex.org/W2082021143', 'https://openalex.org/W2084622111', 'https://openalex.org/W2087305980', 'https://openalex.org/W2087441379', 'https://openalex.org/W2090056328', 'https://openalex.org/W2090279266', 'https://openalex.org/W2091039286', 'https://openalex.org/W2096619153', 'https://openalex.org/W2099981942', 'https://openalex.org/W2103413368', 'https://openalex.org/W2105159282', 'https://openalex.org/W2110929110', 'https://openalex.org/W2112158890', 'https://openalex.org/W2114110121', 'https://openalex.org/W2117690122', 'https://openalex.org/W2120127276', 'https://openalex.org/W2123632788', 'https://openalex.org/W2124626384', 'https://openalex.org/W2128316913', 'https://openalex.org/W2130925452', 'https://openalex.org/W2131581428', 'https://openalex.org/W2133856531', 'https://openalex.org/W2135268524', 'https://openalex.org/W2138092150', 'https://openalex.org/W2139036146', 'https://openalex.org/W2144635371', 'https://openalex.org/W2152058417', 'https://openalex.org/W2159167361', 'https://openalex.org/W2161048718', 'https://openalex.org/W2162050917', 'https://openalex.org/W2162532089', 'https://openalex.org/W2163737726', 'https://openalex.org/W2167459187', 'https://openalex.org/W2167550841', 'https://openalex.org/W2168688375', 'https://openalex.org/W2186205501', 'https://openalex.org/W2202096623', 'https://openalex.org/W2279395133', 'https://openalex.org/W2338295703', 'https://openalex.org/W2340797554', 'https://openalex.org/W2342153330', 'https://openalex.org/W2395209644', 'https://openalex.org/W2399163684', 'https://openalex.org/W2410609247', 'https://openalex.org/W2412102237', 'https://openalex.org/W2417400244', 'https://openalex.org/W4241890711', 'https://openalex.org/W4296086394', 'https://openalex.org/W56279225', 'https://openalex.org/W765976976', 'https://openalex.org/W835961366', 'https://openalex.org/W950397914', 'https://openalex.org/W96307731'], 'related_works': ['https://openalex.org/W3207032379', 'https://openalex.org/W3000000154', 'https://openalex.org/W2811145069', 'https://openalex.org/W2502005031', 'https://openalex.org/W2168017908', 'https://openalex.org/W2088945149', 'https://openalex.org/W2051137913', 'https://openalex.org/W1990933325', 'https://openalex.org/W1484646459', 'https://openalex.org/W1044243266'], 'abstract_inverted_index': {'Macrophage': [0, 197, 394, 554, 917, 1585, 1631, 1728, 1851, 2234, 2456, 2645, 3232], 'migration': [1, 198, 395, 405, 526, 555, 758, 818, 886, 918, 1016, 1586, 1632, 1729, 1783, 1852, 1896, 2004, 2061, 2111, 2144, 2235, 2296, 2351, 2457, 2566, 2646, 2737, 2783, 2873, 2917, 2986, 3082, 3148, 3207, 3233, 3377, 3459, 3507], 'inhibitory': [2, 199, 396, 406, 556, 759, 819, 887, 919, 1017, 1587, 1633, 1730, 1784, 1853, 1897, 2005, 2062, 2112, 2145, 2236, 2297, 2352, 2458, 2506, 2567, 2647, 2738, 2784, 2874, 2918, 2987, 3083, 3149, 3208, 3234, 3378, 3460, 3508, 3866], 'factor': [3, 200, 397, 522, 760, 888, 920, 1018, 1588, 1634, 1731, 1854, 1898, 2006, 2146, 2237, 2298, 2353, 2459, 2507, 2568, 2739, 2785, 2875, 2919, 3084, 3150, 3235, 3379, 3509, 4142], '(MIF)': [4, 201, 398, 1855, 2007, 2299, 2786, 3085, 3380], 'is': [5, 23, 202, 220, 454, 535, 607, 811, 985, 1019, 1058, 1069, 1403, 1509, 1658, 1766, 1900, 1937, 2223, 2354, 2434, 2523, 2533, 2624, 2683, 2740, 3370, 3643, 3818], 'a': [6, 14, 51, 80, 123, 174, 184, 203, 211, 248, 277, 320, 371, 381, 498, 520, 558, 608, 668, 672, 1062, 1070, 1155, 1318, 1325, 1373, 1484, 1490, 1563, 1675, 1702, 1733, 1742, 1812, 2052, 2213, 2355, 2461, 2470, 2674, 2741, 2788, 2878, 2937, 2977, 3105, 3110, 3371, 3416, 3419, 3462, 3644, 3854, 3874, 3931], 'pleiotropic': [7, 204, 540], 'cytokine': [8, 205, 989, 1567, 1706, 2628, 3435, 3590, 4121], 'that': [9, 106, 164, 206, 303, 361, 523, 533, 1068, 1205, 1218, 1243, 1678, 1762, 1941, 2426, 3766, 3789, 3811, 3833, 3846, 3925, 4071, 4083, 4099], 'has': [10, 156, 207, 353, 539, 846, 1241, 2186, 2202, 2423, 2544, 2694, 3791], 'been': [11, 72, 208, 269, 847, 2187, 2203, 2695, 3316], 'implicated': [12, 209], 'in': [13, 27, 90, 142, 149, 152, 169, 210, 224, 287, 339, 346, 349, 366, 468, 500, 615, 764, 855, 894, 926, 1220, 1321, 1407, 1489, 1665, 1674, 1821, 1893, 1902, 2055, 2174, 2189, 2205, 2220, 2439, 2509, 2525, 2538, 2574, 2711, 2841, 2980, 3048, 3411, 3513, 3651, 3684, 3703, 3712, 3750, 3758, 3761, 3774, 3782, 3784, 3797, 3803, 3805, 3821, 3858, 3873, 3887, 3897, 3917, 3947, 3955, 3969, 4093, 4116, 4175], 'broad': [15, 212], 'range': [16, 213, 1156], 'of': [17, 29, 41, 45, 59, 68, 76, 82, 101, 112, 176, 214, 226, 238, 242, 256, 265, 273, 279, 298, 309, 373, 410, 456, 497, 527, 560, 611, 691, 815, 885, 923, 929, 982, 1023, 1040, 1073, 1101, 1136, 1157, 1163, 1185, 1214, 1223, 1248, 1267, 1314, 1334, 1368, 1381, 1411, 1440, 1483, 1493, 1511, 1516, 1523, 1530, 1566, 1597, 1639, 1682, 1705, 1771, 1788, 1808, 1863, 1906, 1927, 1934, 1953, 1977, 2002, 2051, 2059, 2105, 2109, 2138, 2177, 2183, 2192, 2207, 2216, 2246, 2294, 2312, 2349, 2360, 2397, 2541, 2565, 2621, 2704, 2735, 2746, 2832, 2868, 2871, 2915, 2945, 2976, 2984, 3039, 3072, 3080, 3146, 3205, 3239, 3285, 3291, 3294, 3313, 3326, 3333, 3341, 3375, 3405, 3418, 3647, 3697, 3879, 3900, 3907, 3934, 3936, 3944, 3987, 4017, 4039, 4047, 4052, 4066, 4146], 'inflammatory': [18, 34, 215, 231, 616, 842, 856, 863, 1444, 2713, 3652, 3772], 'and': [19, 33, 139, 151, 216, 230, 336, 348, 538, 545, 548, 617, 693, 751, 767, 844, 866, 1050, 1159, 1324, 1480, 1536, 1669, 1790, 1818, 1827, 1856, 1909, 1950, 2009, 2151, 2195, 2200, 2437, 2535, 2537, 2653, 2700, 2838, 3045, 3167, 3199, 3211, 3236, 3252, 3324, 3500, 3516, 3535, 3606, 3653, 3674, 3706, 3760, 3770, 3816, 3845, 3962, 3975, 3999, 4025, 4033, 4054, 4109, 4165], 'oncologic': [20, 217], 'diseases.': [21, 218], 'MIF': [22, 102, 107, 147, 219, 299, 304, 344, 515, 649, 670, 720, 845, 1508, 1561, 1656, 1671, 1700, 1815, 1864, 1975, 2196, 2392, 2422, 2433, 2521, 2530, 2667, 2686, 2833, 2947, 3040, 3103, 3286, 3295, 3342, 3406, 3426, 3558, 3698, 3769, 3843, 3865, 3889, 3937, 4073, 4101], 'unique': [24, 221, 2418], 'among': [25, 222, 1076, 3319], 'cytokines': [26, 223, 4111, 4173], 'terms': [28, 225], 'its': [30, 227, 470, 891, 1739, 2417, 2467, 2571, 2835, 3042, 3077, 3837], 'release': [31, 228, 1657, 3968, 4016], 'profile': [32, 229, 1067, 3933], 'role,': [35, 232], 'notably': [36, 233], 'as': [37, 134, 183, 234, 331, 380, 519, 859, 1562, 1701, 1741, 1767, 1824, 2469, 2936, 3104, 3109, 3202, 3337, 3681, 3853, 3861, 3977, 3979, 4127], 'an': [38, 235, 851, 1404, 1768, 1942, 2429, 3338, 3713, 3775, 3783, 4100], 'endogenous': [39, 236, 1769, 3339, 3373], 'counter-regulator': [40, 237, 1770], 'the': [42, 57, 135, 239, 254, 332, 415, 457, 681, 812, 816, 988, 1038, 1215, 1244, 1341, 1513, 1524, 1528, 1636, 1806, 1894, 1903, 1928, 1932, 1947, 2048, 2056, 2142, 2169, 2175, 2190, 2208, 2309, 2394, 2529, 2539, 2627, 2689, 2698, 2828, 2932, 2973, 2981, 3035, 3073, 3237, 3322, 3327, 3331, 3484, 3738, 3823, 3888, 3898, 3980, 3991, 4018, 4172], 'anti-inflammatory': [43, 113, 128, 240, 310, 325, 435, 1049, 1514, 1949, 2362, 2748, 2882, 3710, 3734, 3748, 3840, 3945, 4077, 4086], 'effects': [44, 158, 241, 355, 541, 699, 837, 1153, 1208, 1232, 1348, 1383, 1482, 1515, 1542, 1638, 1952, 3794, 4106], 'glucocorticoids.': [46, 160, 243, 357], 'In': [47, 85, 244, 282, 1654, 2414, 3308, 3688], 'addition,': [48, 245, 1655, 3309], 'it': [49, 246, 534, 1936, 2201, 2428, 2543], 'exhibits': [50, 247, 1732, 2460], 'catalytic': [52, 249], 'tautomerase': [53, 250, 2008, 2346, 2678, 2732, 2829, 2869, 2934, 3036, 3086, 3203, 3240, 3296, 3890], 'activity': [54, 251, 2679, 2837, 2870, 3044, 3711, 3749, 3946], 'amenable': [55, 252], 'to': [56, 94, 118, 144, 191, 253, 291, 315, 341, 388, 461, 655, 676, 689, 726, 840, 849, 1046, 1234, 1252, 1336, 1339, 1379, 1738, 1760, 1869, 1939, 1973, 2416, 2466, 2655, 2685, 2827, 2911, 3034, 3415, 3422, 3564, 3914, 4010, 4090], 'design': [58, 255, 2699, 3290], 'high': [60, 257, 2701, 2907], 'affinity': [61, 258], 'small': [62, 259, 1971, 2209, 2218, 2705, 3699, 3723], 'molecule': [63, 124, 260, 321, 2210, 2706, 3700], 'inhibitors.': [64, 103, 261, 300], 'Although': [65, 262, 514, 1960, 2520, 3394, 3428], 'several': [66, 99, 263, 296, 1043], 'classes': [67, 100, 264, 297, 2914, 2944, 3696, 3881], 'these': [69, 77, 266, 274, 1315, 2163, 3320, 3395, 3666, 3908, 3927], 'compounds': [70, 267, 3312, 3396, 3693, 3725, 3867, 3909, 3973, 4087], 'have': [71, 268, 531, 850, 1757, 1804, 1964, 2941, 3315, 3408, 3930, 4114], 'identified,': [73, 270], 'biologic': [74, 271, 3895], 'characterization': [75, 272, 3870, 3896], 'molecules': [78, 97, 275, 294, 1972, 2170, 2219, 3878, 3928], 'remains': [79, 276, 1317], 'topic': [81, 278], 'active': [83, 280, 2057, 2347, 2681, 2733, 2830, 2982, 3037], 'investigation.': [84, 281], 'this': [86, 283, 1408, 1809, 1966, 2221, 3802, 3847, 3918, 3948, 4176], 'study,': [87, 284, 3690], 'we': [88, 162, 285, 359, 3691, 3764, 3787, 4097], 'used': [89, 286, 401, 1338], 'vitro': [91, 150, 288, 347, 501, 3759, 3785], 'LPS-driven': [92, 289], 'assays': [93, 290, 3431, 3667], 'characterize': [95, 292], 'representative': [96, 293], 'from': [98, 295, 1370, 1384, 3694], 'We': [104, 120, 301, 317, 3717, 3736, 3800, 3923], 'determined': [105, 302, 3765], 'inhibitors': [108, 305, 2108, 2140, 2707, 3145, 3204, 3293, 3407, 3701, 4074], 'exhibit': [109, 306, 3941], 'distinct': [110, 307, 3733], 'profiles': [111, 308, 3943], 'activity,': [114, 129, 311, 326, 3939], 'especially': [115, 312], 'with': [116, 125, 159, 167, 313, 322, 356, 364, 503, 696, 1061, 1078, 1105, 1168, 1229, 1345, 1540, 1867, 1911, 1923, 2305, 2420, 2688, 2708, 3732, 3795, 3814, 3882, 4029, 4050, 4103], 'regard': [117, 314], 'TNFα.': [119, 316], 'further': [121, 318, 3754, 3852, 4091], 'investigated': [122, 319], 'relatively': [126, 323], 'low': [127, 324, 3747], 'compound': [130, 327, 1401, 1439, 3982], 'T-614': [131, 328, 3743, 3767, 3790, 3817, 4164], '(also': [132, 329], 'known': [133, 330], 'anti-rheumatic': [136, 333], 'drug': [137, 189, 334, 386, 1187, 1269, 2431, 3828, 3848], 'iguratimod),': [138, 335], 'found': [140, 163, 337, 360, 3788, 3924], 'that,': [141, 338, 3719], 'addition': [143, 340, 2415], 'exhibiting': [145, 342], 'selective': [146, 343, 1293, 1374], 'inhibition': [148, 345, 3079, 3844, 3935], 'vivo,': [153, 350], 'iguratimod': [154, 165, 182, 351, 362, 379, 3834], 'also': [155, 352, 1059, 2668], 'additive': [157, 354, 3793], 'Furthermore,': [161, 358], 'synergizes': [166, 363], 'glucocorticoids': [168, 365, 1249, 1335, 1640, 1664, 1683, 1772, 1924, 1954, 1978, 3781, 3796], 'attenuating': [170, 367], 'experimental': [171, 368, 418, 1024, 3806], 'autoimmune': [172, 369, 419, 1025, 3807], 'encephalitis,': [173, 370], 'model': [175, 372, 1492], 'multiple': [177, 195, 374, 392, 841, 867, 1494, 1666, 1961, 2424, 2526, 2670, 2712, 2943, 3310, 3695, 3862, 4128], 'sclerosis.': [178, 196, 375, 393], 'Our': [179, 376, 3830], 'work': [180, 377, 1240], 'identifies': [181, 378], 'valuable': [185, 382], 'new': [186, 383, 2103, 3875], 'candidate': [187, 384, 1406, 3430], 'for': [188, 385, 1021, 1042, 1331, 1443, 2308, 2358, 2697, 2744, 2881, 3400, 3425, 3709, 3753, 3869, 3894, 4170], 'repurposing': [190, 387], 'MIF-relevant': [192, 389], 'diseases,': [193, 390], 'including': [194, 391, 2673, 2949, 3434], '3The': [399], 'abbreviations': [400], 'are:': [402], 'MIF,': [403], 'macrophage': [404, 426, 757, 817, 1015, 1782, 1895, 2003, 2060, 2110, 2143, 2295, 2350, 2736, 2782, 2872, 2916, 2985, 3081, 3147, 3206, 3376, 3458, 3506], 'factor;': [407, 428], 'ANOVA,': [408], 'analysis': [409], 'variance;': [411], 'AUC,': [412], 'area': [413], 'under': [414], 'curve;': [416], 'EAE,': [417], 'encephalomyelitis;': [420], 'LAL,': [421], 'Limulus': [422], 'amebocyte': [423], 'lysate;': [424], 'M-CSF,': [425], 'colony-stimulating': [427], 'MOG,': [429], 'myelin': [430], 'oligodendrocyte': [431], 'glycoprotein;': [432], 'NSAID,': [433], 'non-steroidal': [434, 1485], 'drug;': [436], 'PBS,': [437], 'phosphate-buffered': [438], 'saline;': [439], 'rMIF,': [440], 'recombinant': [441, 3685], 'MIF;': [442], 'RPMI,': [443], 'Roswell': [444], 'Park': [445], 'Memorial': [446], 'Institute;': [447], 'DEX,': [448], 'dexamethasone;': [449], 'VEH,': [450], 'vehicle;': [451], 'T4,': [452, 3330], 'thyroxine.': [453], 'one': [455], 'first': [458], 'cytokine-like': [459], 'proteins': [460], 'be': [462, 1235, 1253, 1337, 3850, 4124], 'discovered': [463, 2942, 3718], '(1.David': [464], 'J.R.': [465, 882, 1082, 2562], 'Delayed': [466], 'hypersensitivity': [467], 'vitro:': [469], 'mediation': [471], 'by': [472, 476, 653, 724, 756, 1211, 1237, 1372, 1593, 1663, 1968, 2012, 2198, 2242, 2300, 2402, 2876, 3288, 3505, 3562, 3678], 'cell-free': [473], 'substances': [474], 'formed': [475], 'lymphoid': [477], 'cell-antigen': [478], 'interaction.Proc.': [479], 'Natl.': [480, 1387, 1447, 2015, 3382], 'Acad.': [481, 1388, 1448, 2016, 3383], 'Sci.': [482, 1389, 1449, 2017, 2408, 3384], 'U.S.A.': [483, 1390, 1450, 2018, 3385], '1966;': [484, 506], '56:': [485], '72-77Crossref': [486], 'PubMed': [487, 509, 568, 625, 662, 733, 780, 831, 901, 942, 995, 1031, 1113, 1145, 1196, 1278, 1307, 1394, 1454, 1500, 1572, 1607, 1649, 1711, 1750, 1796, 2022, 2074, 2117, 2158, 2256, 2324, 2374, 2478, 2581, 2634, 2662, 2760, 2795, 2854, 2890, 2926, 2999, 3061, 3094, 3118, 3161, 3219, 3247, 3303, 3389, 3476, 3529, 3571, 3601, 3661, 4158], 'Scopus': [488, 510, 569, 626, 663, 734, 781, 832, 902, 943, 996, 1032, 1114, 1146, 1197, 1279, 1308, 1395, 1455, 1501, 1573, 1608, 1650, 1712, 1751, 1797, 2023, 2075, 2118, 2159, 2257, 2325, 2375, 2479, 2582, 2635, 2663, 2761, 2855, 2891, 2927, 3000, 3062, 3095, 3119, 3162, 3220, 3248, 3304, 3390, 3477, 3530, 3572, 3602, 3662, 4159], '(1103)': [489], 'Google': [490, 512, 571, 628, 665, 736, 783, 834, 904, 945, 998, 1034, 1116, 1148, 1199, 1281, 1310, 1397, 1457, 1503, 1575, 1610, 1652, 1714, 1753, 1799, 1877, 1918, 2025, 2077, 2120, 2161, 2259, 2327, 2377, 2412, 2481, 2518, 2584, 2637, 2665, 2763, 2796, 2857, 2893, 2929, 3002, 3064, 3097, 3121, 3164, 3222, 3250, 3306, 3392, 3479, 3532, 3574, 3604, 3664, 4161], 'Scholar,': [491, 572, 737, 946, 1117, 1282, 1458, 1576, 1715, 1878, 2078, 2260, 2328, 2482, 2585, 2638, 2764, 2858, 3003, 3065, 3098, 3223, 3575], '2.Bloom': [492], 'B.R.': [493], 'Bennett': [494], 'B.': [495, 876, 1431, 2035, 2084, 2336, 2338, 2556, 2722, 2724, 2802, 2960, 3009, 3263, 3350, 4139], 'Mechanism': [496], 'reaction': [499], 'associated': [502, 1060, 1104, 1910, 2546], 'delayed-type': [504], 'hypersensitivity.Science.': [505], '153:': [507], '80-82Crossref': [508], '(1291)': [511], 'Scholar).': [513, 666, 835, 1035, 1149, 1200, 1311, 1398, 1504, 1653, 1754, 1800, 1919, 2413, 2519, 2666, 2930, 3307, 3393, 4162], 'was': [516], 'originally': [517], 'characterized': [518, 2676], 'T-cell': [521], 'inhibits': [524, 1635, 2834, 3041, 3591, 3768], 'random': [525], 'macrophages,': [528], 'subsequent': [529, 697, 1541], 'investigations': [530], 'shown': [532, 848], 'ubiquitously': [536, 2435], 'expressed': [537, 2436], 'on': [542, 987, 1166, 1520, 1543, 2399, 2626, 4107], 'inflammation,': [543], 'chemotaxis,': [544], 'cell': [546, 619, 765, 1667, 3154, 3514, 3655], 'survival': [547, 2840, 3047], 'proliferation': [549, 766, 3515, 3534, 4145], '(3.Calandra': [550], 'T.': [551, 553, 594, 642, 713, 743, 789, 968, 1546, 1556, 1578, 1584, 1685, 1695, 1778, 1880, 2086, 2099, 2136, 2227, 2233, 2271, 2379, 2496, 2500, 2607, 3129, 3143, 3195, 3362, 3492, 3551, 3630], 'Roger': [552, 2085, 2270], 'factor:': [557, 3209, 3461], 'regulator': [559], 'innate': [561, 1590, 2239], 'immunity.Nat.': [562], 'Rev.': [563, 2405], 'Immunol.': [564, 991, 1027, 1603, 2252, 2630], '2003;': [565, 659, 730, 1747, 2475, 3568], '3:': [566, 3116], '791-800Crossref': [567], '(1364)': [570], '4.Bernhagen': [573], 'J.': [574, 636, 640, 707, 711, 795, 916, 1086, 1303, 1427, 1474, 1548, 1602, 1620, 1687, 1776, 1886, 1990, 1992, 2251, 2273, 2277, 2334, 2513, 2658, 2720, 3156, 3265, 3545, 3549, 3610], 'Krohn': [575, 3611], 'R.': [576, 600, 604, 648, 719, 745, 809, 1129, 1560, 1618, 1624, 1699, 1727, 1780, 1847, 2000, 2095, 2340, 2455, 2504, 2726, 2768, 3279, 3446, 3494, 3557, 3581, 3612, 3636, 3640], 'Lue': [577, 3613], 'H.': [578, 1350, 1362, 1364, 1612, 1774, 2080, 2287, 2291, 2778, 2862, 2895, 3185, 3187, 3189, 3269, 3356, 3614], 'Gregory': [579, 3615], 'J.L.': [580, 3616], 'Zernecke': [581, 3617], 'A.': [582, 590, 1090, 1131, 1286, 1352, 1433, 1558, 1697, 1835, 1843, 1845, 2332, 2486, 2718, 2804, 3011, 3197, 3259, 3438, 3448, 3583, 3618, 3626], 'Koenen': [583, 3619], 'R.R.': [584, 3620], 'Dewor': [585, 3621], 'M.': [586, 870, 914, 965, 1464, 1554, 1582, 1693, 1831, 1837, 2033, 2097, 2231, 2264, 2285, 2289, 2484, 2550, 2604, 2808, 2810, 2814, 2897, 2958, 3015, 3017, 3021, 3125, 3135, 3171, 3177, 3191, 3225, 3358, 3440, 3456, 3622, 4135], 'Georgiev': [587, 3623], 'I.': [588, 3127, 3139, 3624, 4133], 'Schober': [589, 3625], 'Leng': [591, 786, 2092, 3627], 'L.': [592, 630, 701, 787, 1177, 1259, 1719, 2093, 2122, 2126, 2447, 2772, 3539, 3628], 'Kooistra': [593, 3629], 'Fingerle-Rowson': [595, 1621, 3631], 'G.': [596, 874, 1125, 1435, 1622, 2283, 2554, 2774, 3632], 'Ghezzi': [597, 3633], 'P.': [598, 805, 976, 1356, 2615, 2770, 2866, 3634], 'Kleemann': [599, 3635], 'McColl': [601, 3637], 'S.R.': [602, 3638], 'Bucala': [603, 647, 718, 744, 808, 1559, 1623, 1698, 1726, 1779, 1999, 2094, 2454, 2503, 2767, 3278, 3493, 3556, 3639], 'et': [605, 980, 2292, 2619, 3641], 'al.MIF': [606, 3642], 'noncognate': [609, 3645], 'ligand': [610, 1488, 3340, 3646], 'CXC': [612, 3648], 'chemokine': [613, 3649], 'receptors': [614, 1173, 3650], 'atherogenic': [618, 3654], 'recruitment.Nat.': [620, 3656], 'Med.': [621, 658, 729, 897, 2153, 2406, 2577, 2791, 3088, 3113, 3214, 3298, 3567, 3597, 3657], '2007;': [622, 1793, 1874, 1915, 2066, 2991, 3658], '13:': [623, 3659], '587-596Crossref': [624, 3660], '(959)': [627, 3663], 'Scholar5.Leng': [629], 'Metz': [631, 702, 740, 962, 1549, 1688, 1724, 1983, 2452, 2491, 2601, 2775, 2817, 3024, 3276, 3345, 3489, 3540], 'C.N.': [632, 703, 741, 963, 1550, 1689, 1984, 2492, 2602, 2776, 3346, 3490, 3541], 'Fang': [633, 704, 3542], 'Y.': [634, 644, 705, 715, 910, 912, 1982, 2043, 2124, 2130, 2344, 2730, 2798, 2968, 3005, 3069, 3100, 3141, 3181, 3283, 3344, 3543, 3553], 'Xu': [635, 706, 3544], 'Donnelly': [637, 708, 1555, 1694, 2499, 3546], 'S.': [638, 709, 906, 1358, 1460, 2383, 2389, 3102, 3133, 3137, 3173, 3193, 3227, 3231, 3352, 3354, 3442, 3450, 3547], 'Baugh': [639, 710, 3548], 'Delohery': [641, 712, 3550], 'Chen': [643, 714, 798, 3552], 'Mitchell': [645, 716, 1987, 2339, 2725, 3260, 3554], 'R.A.': [646, 717, 739, 1988, 2644, 3261, 3488, 3555], 'signal': [650, 721, 3481, 3559], 'transduction': [651, 722, 3482, 3560], 'initiated': [652, 723, 3561], 'binding': [654, 725, 2049, 2826, 2974, 3033, 3563], 'CD74.J.': [656, 727, 3565], 'Exp.': [657, 728, 896, 1872, 2576, 3566, 3596], '197:': [660, 731, 3569], '1467-1476Crossref': [661, 732, 3570], '(846)': [664, 735, 3573], 'As': [667], 'cytokine,': [669], 'binds': [671], 'CD74-CD44': [673], 'receptor': [674, 821, 1217, 1295, 1376, 1487, 1526, 1930], 'complex': [675, 1255], 'initiate': [677, 1151], 'downstream': [678, 1213, 1522, 1926], 'signaling': [679, 813], 'via': [680, 1154, 1189, 1271, 1641, 2147, 3842, 4151], 'p44/p42': [682], 'mitogen-activated': [683, 747, 1598, 2247, 3496], 'protein': [684, 748, 1533, 1599, 2248, 3497, 3686, 4023], 'kinase': [685, 749, 1534, 1600, 2249, 3498], 'pathway,': [686], 'which': [687, 1164, 3334, 3745, 4080], 'leads': [688, 1378], 'up-regulation': [690], 'prostaglandins': [692], 'phospholipase': [694, 753, 3502], 'A2': [695, 754, 3503], 'pro-inflammatory': [698, 1224, 2836, 3043], '(5.Leng': [700, 3538], '6.Mitchell': [738], 'Peng': [742, 3491], 'Sustained': [746, 3495], '(MAPK)': [750, 3499], 'cytoplasmic': [752, 3501], 'activation': [755, 3504], '(MIF).': [761, 3510], 'Regulatory': [762, 3511], 'role': [763, 854, 893, 1740, 2468, 2573, 3512], 'glucocorticoid': [768, 1056, 1107, 1172, 1186, 1216, 1268, 1290, 1294, 1375, 1486, 1525, 1743, 1819, 1929, 2471, 3517], 'action.J.': [769, 3518], 'Biol.': [770, 932, 1746, 2064, 2314, 2364, 2474, 2750, 2844, 2989, 3051, 3466, 3519], 'Chem.': [771, 933, 2065, 2154, 2315, 2365, 2751, 2845, 2990, 3052, 3089, 3114, 3215, 3299, 3467, 3520], '1999;': [772, 898, 2578, 3521, 3598], '274:': [773, 3522], '18100-18106Abstract': [774, 3523], 'Full': [775, 777, 826, 828, 937, 939, 2069, 2071, 2319, 2321, 2369, 2371, 2755, 2757, 2849, 2851, 2994, 2996, 3056, 3058, 3471, 3473, 3524, 3526], 'Text': [776, 778, 827, 829, 938, 940, 2070, 2072, 2320, 2322, 2370, 2372, 2756, 2758, 2850, 2852, 2995, 2997, 3057, 3059, 3472, 3474, 3525, 3527], 'PDF': [779, 830, 941, 2073, 2323, 2373, 2759, 2853, 2998, 3060, 3475, 3528], '(421)': [782, 3531], 'Scholar7.Shi': [784], 'X.': [785, 793, 2134], 'Wang': [788, 790], 'W.': [791, 807, 1127, 1418, 1423, 1614, 1888, 1890, 2490], 'Du': [792], 'Li': [794, 1178, 1260, 2129, 2131], 'McDonald': [796], 'C.': [797, 880, 1288, 1429, 1468, 1725, 1882, 2128, 2453, 2560, 2818, 3025, 3277, 4137], 'Z.': [799, 1179, 1261], 'Murphy': [800], 'J.W.': [801, 1088], 'Lolis': [802, 2040, 2341, 2727, 2965, 3274], 'E.': [803, 961, 1123, 1284, 1628, 2041, 2342, 2385, 2600, 2728, 2766, 2966, 3275], 'Noble': [804], 'Knudson': [806], 'CD44': [810], 'component': [814], 'factor-CD74': [820], 'complex.Immunity.': [822], '2006;': [823, 1110, 3091, 3468, 4155], '25:': [824, 1875], '595-606Abstract': [825], '(492)': [833], 'These': [836, 1755], 'are': [838, 1037, 1209, 1250, 2650, 3321, 3432, 3675, 4075], 'relevant': [839, 1737, 2465, 2684], 'states,': [843], 'important': [852, 1405], 'pathologic': [853], 'conditions': [857, 4118], 'such': [858, 1823, 3680, 3860, 4126], 'sepsis,': [860], 'rheumatoid': [861, 930], 'arthritis,': [862], 'bowel': [864], 'disease,': [865], 'sclerosis': [868, 4129], '(8.Bozza': [869, 2549], 'Satoskar': [871, 952, 1009, 2551, 2591], 'A.R.': [872, 953, 1010, 2552, 2592], 'Lin': [873, 2553], 'Lu': [875, 2555], 'Humbles': [877, 2557], 'A.A.': [878, 2558], 'Gerard': [879, 2559], 'David': [881, 2561], 'Targeted': [883, 2563], 'disruption': [884, 2564], 'gene': [889, 1445, 1899, 2569], 'reveals': [890, 2570], 'critical': [892, 2572], 'sepsis.J.': [895, 2575, 2843, 3050], '189:': [899, 2579], '341-346Crossref': [900, 2580], '(500)': [903, 2583], 'Scholar9.Onodera': [905], 'Kaneda': [907], 'K.': [908, 955, 1121, 1366, 1415, 2594, 2812, 3019, 3179, 3267, 3454], 'Mizue': [909], 'Koyama': [911], 'Fujinaga': [913], 'Nishihira': [915], 'up-regulates': [921], 'expression': [922, 1596, 2245, 2508], 'matrix': [924], 'metalloproteinases': [925], 'synovial': [927], 'fibroblasts': [928], 'arthritis.J.': [931], '2000;': [934], '275:': [935], '444-450Abstract': [936], '(246)': [944], '10.de': [947, 2586], 'Jong': [948, 2587], 'Y.P.': [949, 2588], 'Abadia-Molina': [950, 2589], 'A.C.': [951, 970, 2590, 2609], 'Clarke': [954, 2593], 'Rietdijk': [956, 2595], 'S.T.': [957, 2596], 'Faubion': [958, 2597], 'W.A.': [959, 2598], 'Mizoguchi': [960, 2599], 'Alsahli': [964, 2603], 'ten': [966, 2605], 'Hove': [967, 2606], 'Keates': [969, 2608], 'Lubetsky': [971, 2610, 3264], 'J.B.': [972, 2330, 2611, 2716], 'Farrell': [973, 2612], 'R.J.': [974, 2262, 2613], 'Michetti': [975, 2614], 'van': [977, 1471, 2616], 'Deventer': [978, 2617], 'S.J.': [979, 2618], 'al.Development': [981, 2620], 'chronic': [983, 1054, 1079, 2622], 'colitis': [984, 2623], 'dependent': [986, 2625], 'MIF.Nat.': [990, 2629], '2001;': [992, 2631, 3216], '2:': [993, 2632, 2793], '1061-1066Crossref': [994, 2633], '(275)': [997, 2636], 'Scholar11.Powell': [999], 'N.D.': [1000], 'Papenfuss': [1001], 'T.L.': [1002], 'McClain': [1003], 'M.A.': [1004, 2903, 3579], 'Gienapp': [1005], 'I.E.': [1006], 'Shawler': [1007], 'T.M.': [1008], 'Whitacre': [1011], 'C.C.': [1012], 'Cutting': [1013], 'edge:': [1014], 'necessary': [1020], 'progression': [1022], 'encephalomyelitis.J.': [1026], '2005;': [1028, 1451, 1604, 2253, 2846, 3053], '175:': [1029], '5611-5614Crossref': [1030], '(57)': [1033], 'Glucocorticoids': [1036, 1150], 'cornerstone': [1039], 'treatment': [1041], 'diseases': [1044, 1822, 3859], 'due': [1045, 3414], 'their': [1047, 1152, 1957, 2306], 'potent': [1048, 3078], 'immunosuppressive': [1051, 1951], 'effects.': [1052, 1959], 'Unfortunately,': [1053], 'systemic': [1055], 'use': [1057], 'potentially': [1063], 'severe': [1064, 2842, 3049], 'adverse': [1065, 1102, 1227, 1347, 1481, 1958], 'effect': [1066, 2173, 2185, 2396], 'significant': [1071, 3792, 3911], 'source': [1072], 'iatrogenic': [1074], 'illness': [1075], 'patients': [1077], 'disease': [1080, 1829, 1908, 2527, 3106, 3773, 3824, 4117], '(12.Curtis': [1081], 'Westfall': [1083], 'A.O.': [1084], 'Allison': [1085], 'Bijlsma': [1087], 'Freeman': [1089], 'George': [1091], 'V.': [1092], 'Kovac': [1093], 'S.H.': [1094], 'Spettell': [1095], 'C.M.': [1096], 'Saag': [1097], 'K.G.': [1098], 'Population-based': [1099], 'assessment': [1100], 'events': [1103, 1316], 'long-term': [1106], 'use.Arthritis': [1108], 'Rheum.': [1109, 1140], '55:': [1111], '420-426Crossref': [1112], '(396)': [1115], '13.Huscher': [1118], 'D.': [1119, 1462, 1626, 1721, 2031, 2089, 2132, 2266, 2269, 2449, 2498, 2800, 2806, 2956, 3007, 3013, 3452, 4131], 'Thiele': [1120, 2284], 'Gromnica-Ihle': [1122], 'Hein': [1124], 'Demary': [1126], 'Dreher': [1128], 'Zink': [1130], 'Buttgereit': [1132, 1180, 1262], 'F.': [1133, 1181, 1263, 1476, 1839, 1850, 1986, 2082, 2816, 2899, 3023], 'Dose-related': [1134], 'patterns': [1135], 'glucocorticoid-induced': [1137, 1298, 1537, 1564, 1595, 1642, 1703, 2244], 'side': [1138, 1291, 1385], 'effects.Ann.': [1139], 'Dis.': [1141], '2009;': [1142, 1497, 2114], '68:': [1143], '1119-1124Crossref': [1144], '(372)': [1147], 'genomic': [1158], 'nongenomic': [1160, 1191, 1273], 'mechanisms,': [1161], 'many': [1162, 3429], 'rely': [1165], 'interactions': [1167, 2687], 'membrane-bound': [1169], 'or': [1170, 1297, 3884], 'cytosolic': [1171], '(14.Jiang': [1174, 1256], 'C.-L.': [1175, 1257], 'Liu': [1176, 1258, 2861, 2896], 'The': [1182, 1264, 1399, 1781, 2345, 2731, 2779, 3950, 3958, 4015, 4064], 'novel': [1183, 1265, 2139, 2361, 2747, 2913], 'strategy': [1184, 1266], 'development': [1188, 1270], 'targeting': [1190, 1272, 2141], 'mechanisms.STEROIDS.': [1192, 1274], '2015;': [1193, 1275], '102:': [1194, 1276, 1452], '27-31Crossref': [1195, 1277], '(26)': [1198, 1280], 'A': [1201, 1301, 1402, 1436, 1891, 2102, 3588], 'common': [1202], 'theory': [1203], 'holds': [1204], 'most': [1206], 'therapeutic': [1207, 1343, 1382, 1948, 3857], 'mediated': [1210], 'transrepression': [1212, 1371, 1544], 'results': [1219, 3673, 4065], 'decreased': [1221], 'production': [1222, 2401, 3436], 'proteins,': [1225], 'whereas': [1226, 3990], '(along': [1228], 'some': [1230, 1759, 4030, 4072], 'therapeutic)': [1231], 'appear': [1233], 'caused': [1236], 'transactivation.': [1238], 'Recent': [1239], 'indicated': [1242], 'actual': [1245], 'mechanistic': [1246], 'properties': [1247, 1756, 2425], 'likely': [1251, 1518], 'more': [1254, 3819, 4076], '15.Ayroldi': [1283], 'Macchiarulo': [1285], 'Riccardi': [1287], 'Targeting': [1289], 'effects:': [1292], 'modulator': [1296, 1565, 1704], 'leucine': [1299, 1538, 1643], 'zipper?': [1300], 'perspective.FASEB': [1302], '2014;': [1304, 1646, 2155, 3158], '28:': [1305], '5055-5070Crossref': [1306], '(71)': [1309], 'Nonetheless,': [1312], 'dissociation': [1313], 'key': [1319], 'goal': [1320], 'steroid': [1322, 1913], 'therapeutics,': [1323], 'true': [1326], '"steroid-sparing': [1327], 'therapy"': [1328], 'would': [1329, 1945], 'allow': [1330], 'lower': [1332, 3885], 'doses': [1333], 'achieve': [1340], 'same': [1342], 'result': [1344], 'fewer': [1346], '(16.Schäcke': [1349], 'Schottelius': [1351], 'Döcke': [1353], 'W.-D.': [1354], 'Strehlke': [1355], 'Jaroch': [1357], 'Schmees': [1359], 'N.': [1360, 1425, 1717, 1884, 2445, 3175, 3183, 3229, 3364], 'Rehwinkel': [1361], 'Hennekes': [1363], 'Asadullah': [1365], 'Dissociation': [1367], 'transactivation': [1369], 'agonist': [1377], 'separation': [1380], 'effects.Proc.': [1386], '2004;': [1391], '101:': [1392], '227-232Crossref': [1393], '(407)': [1396], 'plant-derived': [1400], 'growing': [1409], 'field': [1410], 'therapeutics': [1412], '(17.De': [1413], 'Bosscher': [1414], 'Vanden': [1416], 'Berghe': [1417], 'Beck': [1419], 'I.M.': [1420], 'Van': [1421], 'Molle': [1422], 'Hennuyer': [1424], 'Hapgood': [1426], 'Libert': [1428], 'Staels': [1430], 'Louw': [1432], 'Haegeman': [1434], 'fully': [1437, 2301], 'dissociated': [1438], 'plant': [1441], 'origin': [1442], 'repression.Proc.': [1446], '15827-15832Crossref': [1453], '(225)': [1456], '18.Wüst': [1459], 'Tischner': [1461], 'John': [1463], 'Tuckermann': [1465], 'J.P.': [1466], 'Menzfeld': [1467], 'Hanisch': [1469], 'U.-K.': [1470], 'den': [1472], 'Brandt': [1473], 'Lühder': [1475], 'Reichardt': [1477], 'H.M.': [1478], 'Therapeutic': [1479], 'mouse': [1491], 'sclerosis.PLoS': [1495], 'ONE.': [1496], '4:': [1498], 'e8202-e8210Crossref': [1499], '(66)': [1502], 'Unlike': [1505], 'other': [1506, 4110], 'cytokines,': [1507], 'capable': [1510], 'overriding': [1512], 'glucocorticoids,': [1517, 2421], 'based': [1519], 'interference': [1521, 1922], 'at': [1527, 1931, 2441, 3728, 4007], 'level': [1529, 1933], 'MKP-1': [1531], '(mitogen-activated': [1532], 'phosphatase-1)': [1535], 'zipper,': [1539], '(19.Calandra': [1545, 1684], 'Bernhagen': [1547, 1686, 1775], 'Spiegel': [1551, 1690], 'L.A.': [1552, 1691], 'Bacher': [1553, 1692, 2813, 3020], 'Cerami': [1557, 1696], 'production.Nature.': [1568, 1707], '1995;': [1569, 1708], '377:': [1570, 1709], '68-71Crossref': [1571, 1710], '(1059)': [1574, 1713], '20.Roger': [1577], 'Chanson': [1579, 2228], 'A.-L.': [1580, 2229], 'Knaup-Reymond': [1581, 2230], 'Calandra': [1583, 1777, 2098, 2232, 2495], 'promotes': [1589, 2238], 'immune': [1591, 2240], 'responses': [1592, 2241], 'suppressing': [1594, 2243, 3798, 4060], 'phosphatase-1.Eur.': [1601, 2250], '35:': [1605, 2254], '3405-3413Crossref': [1606, 2255], '(178)': [1609, 2258], 'Scholar21.Fan': [1611], 'Kao': [1613], 'Yang': [1615], 'Y.H.': [1616], 'Gu': [1617], 'Harris': [1619], 'Ngo': [1625], 'Beaulieu': [1627], 'Morand': [1629], 'E.F.': [1630], 'antiinflammatory': [1637], 'zipper.Arthritis': [1644], 'Rheumatol.': [1645, 1873], '66:': [1647], '2059-2070Crossref': [1648], '(38)': [1651], 'triggered': [1659], 'rather': [1660], 'than': [1661, 3826, 4041, 4078], 'suppressed': [1662, 3966], 'types,': [1668], 'plasma': [1670, 1680, 2440], 'levels': [1672, 1681], 'fluctuate': [1673], 'circadian': [1676, 1735, 2463], 'fashion': [1677], 'mirrors': [1679], '22.Petrovsky': [1716], 'Socha': [1718, 2446], 'Silva': [1720, 2448], 'Grossman': [1722, 2450], 'A.B.': [1723, 2451], 'pronounced': [1734, 2462], 'rhythm': [1736, 2464], 'counter-regulator.Immunol.': [1744, 2472], 'Cell': [1745, 2473], '81:': [1748, 2476], '137-143Crossref': [1749, 2477], '(86)': [1752, 2480], 'led': [1758], 'suggest': [1761, 3832, 4082], "MIF's": [1763, 1921], 'primary': [1764], 'function': [1765, 3336], '(23.Flaster': [1773], 'factor-glucocorticoid': [1785], 'dyad:': [1786], 'regulation': [1787], 'inflammation': [1789], 'immunity.Mol.': [1791], 'Endocrinol.': [1792], '21:': [1794], '1267-1280Crossref': [1795], '(220)': [1798], 'Human': [1801, 3457], 'genetic': [1802, 1904], 'studies': [1803, 2164, 2206, 3404, 3537], 'validated': [1805], 'importance': [1807], 'interaction,': [1810], 'showing': [1811, 3810], 'relationship': [1813], 'between': [1814], 'promoter': [1816, 1865], 'polymorphisms': [1817, 1866], 'sensitivity': [1820], 'juvenile': [1825, 1858], 'arthritis': [1826, 1860], "Crohn's": [1828, 1907], '(24.Vivarelli': [1830], "D'Urbano": [1832], 'L.E.': [1833], 'Insalaco': [1834], 'Lunt': [1836], 'Jury': [1838], 'Tozzi': [1840], 'A.E.': [1841], 'Ravelli': [1842], 'Martini': [1844], 'Donn': [1846, 3445], 'De': [1848], 'Benedetti': [1849], 'oligoarticular': [1857], 'idiopathic': [1859], '(o-JIA):': [1861], 'association': [1862], 'response': [1868], 'intra-articular': [1870], 'glucocorticoids.Clin.': [1871], '775-781PubMed': [1876], '25.Griga': [1879], 'Wilkens': [1881], 'Wirkus': [1883], 'Epplen': [1885], 'Schmiegel': [1887], 'Klein': [1889], 'polymorphism': [1892], 'involved': [1901], 'predisposition': [1905], 'cumulative': [1912], 'doses.Hepatogastroenterology.': [1914], '54:': [1916], '784-786PubMed': [1917], 'Because': [1920], 'exists': [1925], 'transrepression,': [1935], 'reasonable': [1938], 'assume': [1940], 'anti-MIF': [1943, 1970, 2193, 2217], 'therapy': [1944, 3813], 'strengthen': [1946], 'without': [1955], 'increasing': [1956], 'research': [1962, 2939], 'groups': [1963, 2940, 3731], 'explored': [1965, 3851], 'concept': [1967], 'using': [1969], 'attenuate': [1974], 'override': [1976], '(26.Senter': [1979], 'P.D.': [1980, 3271], 'Al-Abed': [1981, 2042, 2343, 2729, 2967, 3068, 3140, 3282], 'Benigni': [1985], 'Chesney': [1989, 2493], 'Han': [1991, 2333, 2719], 'Gartner': [1993], 'C.G.': [1994], 'Nelson': [1995], 'S.D.': [1996, 2381], 'Todaro': [1997], 'G.J.': [1998, 3585], 'Inhibition': [2001, 3284], 'biological': [2010], 'activities': [2011, 3841], 'acetaminophen': [2013], 'metabolites.Proc.': [2014], '2002;': [2019, 2366, 2752, 3244, 3300], '99:': [2020], '144-149Crossref': [2021], '(149)': [2024], 'Scholar27.Crichlow': [2026], 'G.V.': [2027, 2952], 'Cheng': [2028, 2953, 3130, 3347], 'K.F.': [2029, 2954, 3348], 'Dabideen': [2030, 2799, 2955, 3006], 'Ochani': [2032, 2807, 2811, 2957, 3014, 3018, 3357], 'Aljabari': [2034, 2335, 2721, 2801, 2959, 3008, 3262, 3349], 'Pavlov': [2036, 2819, 2961, 3026, 3359], 'V.A.': [2037, 2820, 2962, 3027, 3360], 'Miller': [2038, 2643, 2821, 2963, 3028, 3367], 'E.J.': [2039, 2822, 2964, 3029, 3368], 'Alternative': [2044, 2969], 'chemical': [2045, 2970], 'modifications': [2046, 2971, 3071], 'reverse': [2047, 2972], 'orientation': [2050, 2975], 'pharmacophore': [2053, 2978], 'scaffold': [2054, 2979, 3075], 'site': [2058, 2348, 2682, 2693, 2734, 2831, 2983, 3038], 'factor.J.': [2063, 2988], '282:': [2067, 2992], '23089-23095Abstract': [2068, 2993], '(50)': [2076, 2664, 3001], '28.Ouertatani-Sakouhi': [2079], 'El-Turk': [2081, 2898], 'Fauvet': [2083], 'Le': [2087, 2267], 'Roy': [2088, 2268], 'Karpinar': [2090], 'D.P.': [2091], 'Zweckstetter': [2096], 'Lashuel': [2100, 2904], 'H.A.': [2101, 2905], 'class': [2104], 'isothiocyanate-based': [2106], 'irreversible': [2107], 'factor.Biochemistry.': [2113], '48:': [2115], '9858-9870Crossref': [2116], '(51)': [2119], 'Scholar29.Xu': [2121], 'Zhang': [2123], 'Zheng': [2125], 'Qiao': [2127], 'Zhen': [2133], 'Hou': [2135], 'Discovery': [2137], 'structure-based': [2148], 'virtual': [2149], 'screening': [2150, 2703, 2909], 'bioassays.J.': [2152], '57:': [2156], '3737-3745Crossref': [2157], '(65)': [2160], 'Scholar),': [2162, 3122, 3165, 3251, 3480, 3533, 3605, 3665], 'did': [2165], 'not': [2166, 3669, 3921], 'show': [2167, 4070], 'whether': [2168], 'had': [2171, 3746], 'any': [2172], 'absence': [2176, 2540], 'exogenously': [2178], 'added': [2179], 'MIF.': [2180], 'This': [2181, 2692], 'type': [2182], 'synergistic': [2184], 'observed': [2188, 3839], 'context': [2191, 2222, 3899, 3919], 'antibodies': [2194, 2303], 'silencing': [2197], 'siRNA,': [2199], 'suggested': [2204], 'ISO-1.': [2211], 'However,': [2212, 4096], 'dedicated': [2214], 'study': [2215], 'still': [2224, 4113], 'lacking': [2225], '(20.Roger': [2226], '30.Kerschbaumer': [2261], 'Rieger': [2263], 'Völkel': [2265], 'Garbaraviciene': [2272], 'Boehncke': [2274], 'W.-H.': [2275], 'Müllberg': [2276], 'Hoet': [2278], 'R.M.': [2279], 'Wood': [2280], 'C.R.': [2281], 'Antoine': [2282], 'Savidis-Dacho': [2286], 'Dockal': [2288], 'Ehrlich': [2290], 'al.Neutralization': [2293], 'human': [2302, 3902], 'correlates': [2304], 'specificity': [2307], 'β-sheet': [2310], 'structure': [2311], 'MIF.J.': [2313], '2012;': [2316], '287:': [2317], '7446-7455Abstract': [2318], '(48)': [2326, 3478], '31.Lubetsky': [2329], 'Dios': [2331, 2717], 'Ruzsicska': [2337, 2723], 'potential': [2356, 2710, 2742, 2879, 3372, 3399, 3855], 'target': [2357, 2743], 'discovery': [2359, 2745, 3210, 3238], 'agents.J.': [2363, 2749], '277:': [2367, 2753], '24976-24982Abstract': [2368, 2754], '(243)': [2376, 2762], 'Scholar32.Stathas': [2378], 'Athanassiou': [2380], 'Drakouli': [2382], 'Giannopoulou': [2384], 'Mastronikolis': [2386], 'N.S.': [2387], 'Naxakis': [2388], 'Aletras': [2390], 'A.J.': [2391], 'attenuates': [2393, 3771], 'suppressive': [2395], 'dexamethasone': [2398, 3815], 'IL-6': [2400], 'nasal': [2403], 'polyp.Eur.': [2404], 'Pharmacol.': [2407, 3157], '2013;': [2409], '17:': [2410], '1455-1466PubMed': [2411], 'interaction': [2419], 'make': [2427], 'attractive': [2430], 'target.': [2432], 'detectable': [2438], 'nanogram/ml': [2442], 'concentrations': [2443, 4008], '(22.Petrovsky': [2444], '33.Bacher': [2483], 'Meinhardt': [2485], 'Lan': [2487], 'H.Y.': [2488], 'Mu': [2489], 'J.A.': [2494], 'Gemsa': [2497], 'Atkins': [2501], 'R.C.': [2502], 'Migration': [2505], 'experimentally': [2510], 'induced': [2511], 'endotoxemia.Am.': [2512], 'Pathol.': [2514], '1997;': [2515], '150:': [2516], '235-246PubMed': [2517], 'deletion': [2522], 'beneficial': [2524], 'conditions,': [2528], 'KO': [2531], 'animal': [2532], 'healthy': [2534], 'long-lived,': [2536], 'intervention': [2542], 'no': [2545], 'health': [2547], 'problems': [2548], '34.Harper': [2639], 'J.M.': [2640], 'Wilkinson': [2641], 'J.E.': [2642], 'factor-knockout': [2648], 'mice': [2649], 'long': [2651], 'lived': [2652], 'respond': [2654], 'caloric': [2656], 'restriction.FASEB': [2657], '2010;': [2659, 2923], '24:': [2660], '2436-2442Crossref': [2661], 'possesses': [2669], 'enzymatic': [2671, 3938], 'activities,': [2672], 'well': [2675, 3978], 'dopachrome': [2677, 2933], 'whose': [2680], 'CD74': [2690], 'receptor.': [2691], 'exploited': [2696], 'throughput': [2702, 2908], 'disease-modifying': [2709], 'states': [2714], '(31.Lubetsky': [2715], '35.Rosengren': [2765], 'Aman': [2769], 'Jacobsson': [2771], 'Odh': [2773], 'Rorsman': [2777], 'immunoregulatory': [2780], 'mediator': [2781], 'catalyzes': [2787], 'tautomerization': [2789], 'reaction.Mol.': [2790], '1996;': [2792], '143-149Crossref': [2794], 'Scholar36.Al-Abed': [2797], 'Valster': [2803, 3010], 'Messmer': [2805, 3012], 'Tanovic': [2809, 3016], 'Nicoletti': [2815, 3022], 'Tracey': [2823, 3030, 3365], 'K.J.': [2824, 3031, 3366], 'ISO-1': [2825, 3032, 3074, 3108], 'increases': [2839, 3046], '280:': [2847, 3054], '36541-36544Abstract': [2848, 3055], '(264)': [2856, 3063], '37.Healy': [2859], 'Z.R.': [2860], 'Holtzclaw': [2863], 'W.D.': [2864], 'Talalay': [2865], 'Inactivation': [2867], 'sulforaphane:': [2877], 'biomarker': [2880], 'intervention.Cancer': [2883], 'Epidemiol.': [2884], 'Biomarkers': [2885], 'Prev.': [2886], '2011;': [2887, 3115, 3386], '20:': [2888], '1516-1523Crossref': [2889], '(41)': [2892, 3096], 'Scholar38.Ouertatani-Sakouhi': [2894], 'Cuny': [2900], 'G.D.': [2901], 'Glicksman': [2902], 'Kinetic-based': [2906], 'assay': [2910, 2935, 3891], 'discover': [2912], 'inhibitors.J.': [2920], 'Biomol.': [2921], 'Screen.': [2922], '15:': [2924], '347-358Crossref': [2925], '(10)': [2928], 'Using': [2931, 3756], 'foundation,': [2938], 'reversible': [2946], 'inhibitors,': [2948], 'isoxazolines': [2950], '(27.Crichlow': [2951], '36.Al-Abed': [3004], '39.Cheng': [3066], 'K.-F.': [3067, 3131], 'Critical': [3070], 'improve': [3076], 'activity.Bioorg.': [3087], 'Lett.': [3090], '16:': [3092], '3376-3379Crossref': [3093], '40.Al-Abed': [3099], 'VanPatten': [3101, 3132, 3351], 'target:': [3107], 'proof-of-concept': [3111], 'therapeutic.Future': [3112], '45-63Crossref': [3117], '(78)': [3120], 'pyrimidazoles': [3123], '(41.Vujicic': [3124], 'Nikolic': [3126], 'Krajnovic': [3128], 'He': [3134], 'Stosic-Grujicic': [3136], 'Stojanovic': [3138], 'Saksida': [3142], 'Novel': [3144], 'prevent': [3151], 'cytokine-induced': [3152], 'β': [3153], 'death.Eur.': [3155], '740:': [3159], '683-689Crossref': [3160], '(11)': [3163], 'coumarin': [3166, 3959], 'chromene': [3168, 3741], 'analogs': [3169], '(42.Orita': [3170], 'Yamamoto': [3172, 3226], 'Katayama': [3174, 3228], 'Aoki': [3176], 'Takayama': [3178], 'Yamagiwa': [3180], 'Seki': [3182], 'Suzuki': [3184], 'Kurihara': [3186], 'Sakashita': [3188], 'Takeuchi': [3190], 'Fujita': [3192, 3230], 'Yamada': [3194], 'Tanaka': [3196], 'Coumarin': [3198], 'chromen-4-one': [3200], 'analogues': [3201], 'x-ray': [3212], 'crystallography.J.': [3213], '44:': [3217], '540-547Crossref': [3218], '(95)': [3221], '43.Orita': [3224], 'inhibitors.Curr.': [3241], 'Pharm.': [3242], 'Des.': [3243], '8:': [3245], '1297-1317Crossref': [3246], '(58)': [3249], 'aromatic': [3253], 'amino': [3254], 'acid': [3255], 'Schiff': [3256], 'bases': [3257], '(44.Dios': [3258], "O'Connor": [3266], 'Liao': [3268], 'Senter': [3270], 'Manogue': [3272], 'K.R.': [3273], 'Callaway': [3280], 'D.J.': [3281], 'bioactivity': [3287], 'rational': [3289], 'pharmacological': [3292], 'activity.J.': [3297, 3595], '45:': [3301], '2410-2416Crossref': [3302], '(111)': [3305], 'individual': [3311], 'interest': [3314], 'identified;': [3317], 'notable': [3318], 'l-': [3323], 'd-isomers': [3325], 'metabolic': [3328], 'hormone': [3329, 4000], 'former': [3332], 'may': [3335, 3835, 4123], '(45.Al-Abed': [3343], 'Blau': [3353], 'Lee': [3355], 'Coleman': [3361], 'Meurice': [3363], 'Thyroxine': [3369], 'antagonist': [3374], 'activity.Proc.': [3381], '108:': [3387], '8224-8227Crossref': [3388], '(40)': [3391], 'hold': [3397], 'great': [3398], 'clinical': [3401], 'application,': [3402], 'preclinical': [3403], 'proven': [3409, 3463], 'problematic,': [3410], 'large': [3412], 'part': [3413], 'lack': [3417], 'unified': [3420], 'approach': [3421], 'developing': [3423], 'bioassays': [3424], 'activity.': [3427], 'employed,': [3433], '(46.Kudrin': [3437], 'Scott': [3439], 'Martin': [3441], 'Chung': [3443], 'C.-W.': [3444], 'McMaster': [3447], 'Ellison': [3449], 'Ray': [3451, 3453], 'Binks': [3455], 'immunomodulatory': [3464], 'cytokine?.J.': [3465], '281:': [3469], '29641-29651Abstract': [3470], 'through': [3483], 'ERK': [3485], 'pathway': [3486], '(6.Mitchell': [3487], 'apoptosis': [3536], '47.Hudson': [3576], 'J.D.': [3577], 'Shoaibi': [3578], 'Maestro': [3580], 'Carnero': [3582], 'Hannon': [3584], 'Beach': [3586], 'D.H.': [3587], 'proinflammatory': [3589], 'p53': [3592], 'tumor': [3593], 'suppressor': [3594], '190:': [3599], '1375-1382Crossref': [3600], '(576)': [3603], 'chemotaxis': [3607], 'experiments': [3608], '(4.Bernhagen': [3609], 'do': [3668], 'always': [3670], 'produce': [3671], 'robust': [3672], 'easily': [3676], 'confounded': [3677], 'factors': [3679], 'contaminating': [3682], 'endotoxin': [3683], 'preparations.': [3687], 'our': [3689, 3722, 3751, 4067], 'selected': [3692, 3737, 3868, 3893], '(detailed': [3702], 'Table': [3704], '1)': [3705, 4024], 'screened': [3707], 'them': [3708], 'LPS-treated': [3714, 3901], 'monocyte': [3715], 'system.': [3716], 'even': [3720], 'within': [3721], 'cohort,': [3724], 'segregated': [3726, 4027], 'into': [3727], 'least': [3729], 'three': [3730], 'profiles.': [3735], 'clinically': [3739, 3838], 'utilized': [3740], 'derivative': [3742], '(iguratimod),': [3744], 'screen,': [3752], 'study.': [3755, 4177], 'MIF-dependent': [3757, 3776], 'vivo': [3762, 3804], 'studies,': [3763], 'fashion.': [3777], 'When': [3778], 'tested': [3779], 'alongside': [3780], 'context,': [3786], 'inflammation.': [3799], 'verified': [3801], 'encephalomyelitis': [3808], '(EAE),': [3809], 'combination': [3812], 'efficacious': [3820], 'treating': [3822], 'phenotype': [3825], 'either': [3827], 'alone.': [3829], 'data': [3831], 'exert': [3836], 'should': [3849, 4088], 'steroid-sparing': [3856], 'sclerosis.TABLE': [3863], '1Representative': [3864], 'Open': [3871], 'table': [3872], 'tab': [3876], 'Small': [3877], 'various': [3880], 'micromolar': [3883], 'IC50': [3886], 'were': [3892, 3953, 4035], 'monocytes': [3903], '(Table': [3904], '1).': [3905], 'None': [3906], 'exhibited': [3910, 3984, 4044, 4167], 'toxicity': [3912], 'up': [3913, 4009], '50': [3915, 4011], 'μm': [3916, 4012], '(data': [3920], 'shown).': [3922], 'although': [3926], 'all': [3929, 4171], 'similar': [3932], 'they': [3940], 'diverse': [3942], 'bioassay.': [3949], 'clearest': [3951], 'distinctions': [3952], 'observable': [3954], 'TNFα': [3956, 3967, 3988, 4006, 4061, 4108], 'release.': [3957], 'derivatives': [3960], 'K-679': [3961], 'K-680': [3963], 'almost': [3964, 4003], 'completely': [3965, 4004], 'monocytes;': [3970], 'two': [3971], 'isoxazole': [3972, 3994], '(ISO-1': [3974], 'ISO-66)': [3976], 'pyrimidazole': [3981], 'K-664.1': [3983], 'moderate': [3985, 4045], 'suppression': [3986, 4046, 4122, 4169], 'release;': [3989], 'chromene-derived': [3992], 'T-614,': [3993], 'ISO-92,': [3995], 'carbonyl': [3996], 'oxime': [3997], 'OXIM-11,': [3998], 'isomer': [4001], 'd-T4': [4002, 4043], 'spared': [4005, 4056], '(Fig.': [4013, 4062], '1A).': [4014], 'chemokines': [4019], 'MCP-1': [4020, 4040], '(macrophage': [4021], 'chemoattractant': [4022], 'IL-8': [4026, 4048, 4057], 'similarly,': [4028], 'exceptions:': [4031], 'ISO-92': [4032], 'K664.1': [4034], 'both': [4036], 'stronger': [4037], 'suppressors': [4038], 'TNFα;': [4042, 4053], 'compared': [4049], 'sparing': [4051], 'ISO-66': [4055], 'despite': [4058], 'moderately': [4059], '1B).': [4063], 'phenotypic': [4068], 'screen': [4069], 'others,': [4079], 'might': [4081], 'only': [4084], 'strong': [4085, 4120], 'advance': [4089], 'testing': [4092], 'MIF-specific': [4094], 'assays.': [4095], 'hypothesized': [4098], 'inhibitor': [4102], 'less': [4104], 'profound': [4105], 'could': [4112], 'usefulness': [4115], 'where': [4119], 'undesirable,': [4125], '(48.Widera': [4130], 'Mikenberg': [4132], 'Elvers': [4134], 'Kaltschmidt': [4136, 4138], 'Tumor': [4140], 'necrosis': [4141], 'α': [4143], 'triggers': [4144], 'adult': [4147], 'neural': [4148], 'stem': [4149], 'cells': [4150], 'IKK/NF-κB': [4152], 'signaling.BMC': [4153], 'Neurosci.': [4154], '7:': [4156], '64Crossref': [4157], '(188)': [4160], 'Both': [4163], 'OXIM-11': [4166], 'minimal': [4168], 'analyzed': [4174], 'T-61': [4178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2540884398', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-07T04:29:43.170567', 'created_date': '2016-11-04'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
