Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2088945149', 'doi': 'https://doi.org/10.1073/pnas.1107023108', 'title': 'Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74', 'display_name': 'Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74', 'publication_year': 2011, 'publication_date': '2011-10-03', 'ids': {'openalex': 'https://openalex.org/W2088945149', 'doi': 'https://doi.org/10.1073/pnas.1107023108', 'mag': '2088945149', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21969590', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3198363'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1107023108', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.1107023108', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109349108', 'display_name': 'Daniel Heinrichs', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Daniel Heinrichs', 'raw_affiliation_strings': ['Medical Department III and'], 'affiliations': [{'raw_affiliation_string': 'Medical Department III and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035408184', 'display_name': 'Meike Knauel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Meike Knauel', 'raw_affiliation_strings': ['Institute of Biochemistry and Molecular Cell Biology, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany;'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biochemistry and Molecular Cell Biology, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany;', 'institution_ids': ['https://openalex.org/I887968799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046380470', 'display_name': 'C Offermanns', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Christian Offermanns', 'raw_affiliation_strings': ['Medical Department III and'], 'affiliations': [{'raw_affiliation_string': 'Medical Department III and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070183360', 'display_name': 'Marie‐Luise Berres', 'orcid': 'https://orcid.org/0000-0002-8009-948X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Marie-Luise Berres', 'raw_affiliation_strings': ['Medical Department III and'], 'affiliations': [{'raw_affiliation_string': 'Medical Department III and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016668331', 'display_name': 'Andreas Nellen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Andreas Nellen', 'raw_affiliation_strings': ['Medical Department III and'], 'affiliations': [{'raw_affiliation_string': 'Medical Department III and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008065494', 'display_name': 'Lin Leng', 'orcid': 'https://orcid.org/0000-0002-0605-358X'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lin Leng', 'raw_affiliation_strings': ['Rheumatology Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; and'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; and', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019383482', 'display_name': 'P Schmitz', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Petra Schmitz', 'raw_affiliation_strings': ['Medical Department III and'], 'affiliations': [{'raw_affiliation_string': 'Medical Department III and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113432815', 'display_name': 'Richard Bucala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Bucala', 'raw_affiliation_strings': ['Rheumatology Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; and'], 'affiliations': [{'raw_affiliation_string': 'Rheumatology Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; and', 'institution_ids': ['https://openalex.org/I32971472']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006242340', 'display_name': 'Christian Trautwein', 'orcid': 'https://orcid.org/0000-0003-2762-8247'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Christian Trautwein', 'raw_affiliation_strings': ['Medical Department III and'], 'affiliations': [{'raw_affiliation_string': 'Medical Department III and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100603203', 'display_name': 'Christian Weber', 'orcid': 'https://orcid.org/0000-0003-4610-8714'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christian Weber', 'raw_affiliation_strings': ['Institute of Cardiovascular Prevention, The Ludwig Maximilians University, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cardiovascular Prevention, The Ludwig Maximilians University, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080194585', 'display_name': 'Jürgen Bernhagen', 'orcid': 'https://orcid.org/0000-0003-2996-2652'}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jürgen Bernhagen', 'raw_affiliation_strings': ['Institute of Biochemistry and Molecular Cell Biology, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany;'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biochemistry and Molecular Cell Biology, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany;', 'institution_ids': ['https://openalex.org/I887968799']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112093828', 'display_name': 'Hermann E. Wasmuth', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hermann E. Wasmuth', 'raw_affiliation_strings': ['Medical Department III and'], 'affiliations': [{'raw_affiliation_string': 'Medical Department III and', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.062, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 139, 'citation_normalized_percentile': {'value': 0.902368, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '108', 'issue': '42', 'first_page': '17444', 'last_page': '17449'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13254', 'display_name': 'Macrophage Migration Inhibitory Factor', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13254', 'display_name': 'Macrophage Migration Inhibitory Factor', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9008, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd74', 'display_name': 'CD74', 'score': 0.8821192}, {'id': 'https://openalex.org/keywords/hepatic-stellate-cell', 'display_name': 'Hepatic stellate cell', 'score': 0.5133792}], 'concepts': [{'id': 'https://openalex.org/C104177226', 'wikidata': 'https://www.wikidata.org/wiki/Q15311903', 'display_name': 'Macrophage migration inhibitory factor', 'level': 3, 'score': 0.98532915}, {'id': 'https://openalex.org/C119997001', 'wikidata': 'https://www.wikidata.org/wiki/Q21113110', 'display_name': 'CD74', 'level': 5, 'score': 0.8821192}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.6102049}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.53346413}, {'id': 'https://openalex.org/C176891718', 'wikidata': 'https://www.wikidata.org/wiki/Q1997459', 'display_name': 'Hepatic stellate cell', 'level': 2, 'score': 0.5133792}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.48406425}, {'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.44095868}, {'id': 'https://openalex.org/C180361614', 'wikidata': 'https://www.wikidata.org/wiki/Q7202242', 'display_name': 'Platelet-derived growth factor receptor', 'level': 4, 'score': 0.4333498}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.43152407}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.40149188}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.382618}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37518677}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.34922576}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.34532946}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.30995858}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3007382}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29368907}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29143167}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.25985062}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.18364778}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.12203467}, {'id': 'https://openalex.org/C2778814158', 'wikidata': 'https://www.wikidata.org/wiki/Q959350', 'display_name': 'MHC class II', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000944', 'descriptor_name': 'Antigens, Differentiation, B-Lymphocyte', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000949', 'descriptor_name': 'Histocompatibility Antigens Class II', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019746', 'descriptor_name': 'Intramolecular Oxidoreductases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008106', 'descriptor_name': 'Liver Cirrhosis, Experimental', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D008263', 'descriptor_name': 'Macrophage Migration-Inhibitory Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000944', 'descriptor_name': 'Antigens, Differentiation, B-Lymphocyte', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000944', 'descriptor_name': 'Antigens, Differentiation, B-Lymphocyte', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055166', 'descriptor_name': 'Hepatic Stellate Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055166', 'descriptor_name': 'Hepatic Stellate Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D055166', 'descriptor_name': 'Hepatic Stellate Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D055166', 'descriptor_name': 'Hepatic Stellate Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000949', 'descriptor_name': 'Histocompatibility Antigens Class II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000949', 'descriptor_name': 'Histocompatibility Antigens Class II', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019746', 'descriptor_name': 'Intramolecular Oxidoreductases', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019746', 'descriptor_name': 'Intramolecular Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019746', 'descriptor_name': 'Intramolecular Oxidoreductases', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D019746', 'descriptor_name': 'Intramolecular Oxidoreductases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008106', 'descriptor_name': 'Liver Cirrhosis, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008106', 'descriptor_name': 'Liver Cirrhosis, Experimental', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D008106', 'descriptor_name': 'Liver Cirrhosis, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008106', 'descriptor_name': 'Liver Cirrhosis, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008263', 'descriptor_name': 'Macrophage Migration-Inhibitory Factors', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D008263', 'descriptor_name': 'Macrophage Migration-Inhibitory Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008263', 'descriptor_name': 'Macrophage Migration-Inhibitory Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008263', 'descriptor_name': 'Macrophage Migration-Inhibitory Factors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010982', 'descriptor_name': 'Platelet-Derived Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010982', 'descriptor_name': 'Platelet-Derived Growth Factor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1107023108', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3198363', 'pdf_url': 'https://europepmc.org/articles/pmc3198363?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198363', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21969590', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1107023108', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1533257460', 'https://openalex.org/W1574734561', 'https://openalex.org/W1584642143', 'https://openalex.org/W1734802175', 'https://openalex.org/W1973610607', 'https://openalex.org/W1974433996', 'https://openalex.org/W1979637012', 'https://openalex.org/W1989832114', 'https://openalex.org/W1990362001', 'https://openalex.org/W1991838762', 'https://openalex.org/W2000679354', 'https://openalex.org/W2010638326', 'https://openalex.org/W2025313459', 'https://openalex.org/W2029174607', 'https://openalex.org/W2037460695', 'https://openalex.org/W2039411604', 'https://openalex.org/W2040598177', 'https://openalex.org/W2040943550', 'https://openalex.org/W2045853353', 'https://openalex.org/W2047308155', 'https://openalex.org/W2052245563', 'https://openalex.org/W2057793946', 'https://openalex.org/W2060893427', 'https://openalex.org/W2062824264', 'https://openalex.org/W2067583186', 'https://openalex.org/W2072187322', 'https://openalex.org/W2085046655', 'https://openalex.org/W2097139406', 'https://openalex.org/W2103004412', 'https://openalex.org/W2104193042', 'https://openalex.org/W2107807887', 'https://openalex.org/W2111288662', 'https://openalex.org/W2112377527', 'https://openalex.org/W2117810566', 'https://openalex.org/W2118029488', 'https://openalex.org/W2120590109', 'https://openalex.org/W2124482899', 'https://openalex.org/W2127481999', 'https://openalex.org/W2131117602', 'https://openalex.org/W2131631258', 'https://openalex.org/W2136547076', 'https://openalex.org/W2144626362', 'https://openalex.org/W2158498082', 'https://openalex.org/W2161048718', 'https://openalex.org/W2164596117', 'https://openalex.org/W2321119966', 'https://openalex.org/W2604337567', 'https://openalex.org/W4211260107', 'https://openalex.org/W4237813261', 'https://openalex.org/W4255712601'], 'related_works': ['https://openalex.org/W3207032379', 'https://openalex.org/W3202379432', 'https://openalex.org/W2811145069', 'https://openalex.org/W2502005031', 'https://openalex.org/W2168017908', 'https://openalex.org/W2088945149', 'https://openalex.org/W2051137913', 'https://openalex.org/W1990933325', 'https://openalex.org/W1484646459', 'https://openalex.org/W1044243266'], 'abstract_inverted_index': {'Macrophage': [0], 'migration': [1, 126], 'inhibitory': [2, 133], 'factor': [3], '(MIF)': [4], 'is': [5, 20, 226], 'a': [6, 21, 26, 92, 99, 163, 208, 218], 'pleiotropic': [7], 'inflammatory': [8, 16], 'cytokine': [9], 'that': [10, 225], 'has': [11, 40], 'been': [12, 43], 'implicated': [13], 'in': [14, 37, 58, 68, 78, 86, 111, 162, 167, 186, 212, 233], 'various': [15], 'diseases.': [17, 247], 'Chronic': [18], 'inflammation': [19], 'mainstay': [22], 'of': [23, 29, 35, 71, 102, 129, 135, 157, 170, 175, 184, 197, 223, 245], 'liver': [24, 38, 73, 76, 195, 246], 'fibrosis,': [25], 'leading': [27], 'cause': [28], 'morbidity': [30], 'worldwide,': [31], 'but': [32, 89], 'the': [33, 145, 155, 173, 229], 'role': [34, 52, 183], 'MIF': [36, 103, 114, 136, 149, 153, 206, 224, 238], 'scarring': [39, 196], 'not': [41, 90], 'yet': [42], 'elucidated.': [44], 'Here': [45], 'we': [46, 142, 216], 'have': [47], 'uncovered': [48], 'an': [49], 'unexpected': [50], 'antifibrotic': [51, 188, 221], 'for': [53, 243], 'MIF.': [54, 180], 'Mice': [55], 'genetically': [56], 'deleted': [57], 'Mif': [59, 61, 79], '(': [60], '−/−': [62, 80, 199], ')': [63], 'showed': [64], 'strongly': [65], 'increased': [66], 'fibrosis': [67, 77], 'two': [69], 'models': [70], 'chronic': [72], 'injury.': [74], 'Pronounced': [75], 'mice': [81, 202], 'was': [82, 109, 190], 'associated': [83], 'with': [84, 204], 'alterations': [85], 'fibrosis-relevant': [87], 'genes,': [88], 'by': [91, 139, 179, 193, 228], 'changed': [93], 'intrahepatic': [94], 'immune': [95], 'cell': [96], 'infiltration.': [97], 'Next,': [98], 'direct': [100], 'impact': [101], 'on': [104, 120, 151], 'hepatic': [105], 'stellate': [106], 'cells': [107], '(HSC)': [108], 'assessed': [110], 'vitro.': [112], 'Although': [113], 'alone': [115], 'had': [116], 'only': [117], 'marginal': [118], 'effects': [119, 134], 'HSCs,': [121], 'it': [122], 'markedly': [123], 'inhibited': [124], 'PDGF-induced': [125, 176], 'and': [127, 239], 'proliferation': [128], 'these': [130], 'cells.': [131], 'The': [132, 181, 235], 'were': [137], 'mediated': [138, 227], 'CD74,': [140], 'which': [141], 'detected': [143], 'as': [144, 241], 'most': [146], 'abundant': [147], 'known': [148], 'receptor': [150], 'HSCs.': [152, 234], 'promoted': [154], 'phosphorylation': [156], 'AMP-activated': [158], 'protein': [159], 'kinase': [160], '(AMPK)': [161], 'CD74-dependent': [164], 'manner': [165], 'and,': [166], 'turn,': [168], 'inhibition': [169, 174], 'AMPK': [171], 'reversed': [172], 'HSC': [177], 'activation': [178], 'pivotal': [182], 'CD74': [185, 240], 'MIF-mediated': [187], 'properties': [189], 'further': [191], 'supported': [192], 'augmented': [194], 'Cd74': [198], 'mice.': [200], 'Moreover,': [201], 'treated': [203], 'recombinant': [205], 'displayed': [207], 'reduced': [209], 'fibrogenic': [210], 'response': [211], 'vivo.': [213], 'In': [214], 'conclusion,': [215], 'describe': [217], 'previously': [219], 'unexplored': [220], 'function': [222], 'CD74/AMPK': [230], 'signaling': [231], 'pathway': [232], 'results': [236], 'imply': [237], 'targets': [242], 'treatment': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2088945149', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-02T04:25:45.480464', 'created_date': '2016-06-24'}