Title: Macrophage Migration Inhibitory Factor promotes HCC progression in vivo via the receptor CD74
Abstract:Macrophage Migration Inhibitory Factor (MIF) is a proinflammatory cytokine with chemokine-like functions. Analysis of the GEPIA database revealed an increased expression of MIF in human hepatocellular...Macrophage Migration Inhibitory Factor (MIF) is a proinflammatory cytokine with chemokine-like functions. Analysis of the GEPIA database revealed an increased expression of MIF in human hepatocellular (HCC) tumor tissue and high expression levels were associated with decreased survival in HCC patients. Referring to the MIF receptors, CD74 has been identified as an important target of MIF in malignant diseases. In this study, we analyze the functional role of MIF and its receptor CD74 in HCC progression in vitro and in vivo using an experimental murine model of HCC.Read More
Publication Year: 2020
Publication Date: 2020-01-01
Language: en
Type: article
Indexed In: ['crossref']
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