Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2410968240', 'doi': 'https://doi.org/10.1152/ajpcell.1996.270.1.c259', 'title': 'Transcriptional regulation of endothelial constitutive PGHS-1 expression by phorbol ester', 'display_name': 'Transcriptional regulation of endothelial constitutive PGHS-1 expression by phorbol ester', 'publication_year': 1996, 'publication_date': '1996-01-01', 'ids': {'openalex': 'https://openalex.org/W2410968240', 'doi': 'https://doi.org/10.1152/ajpcell.1996.270.1.c259', 'mag': '2410968240', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8772452'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1996.270.1.c259', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055226696', 'display_name': 'Xiangyang Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I919571938', 'display_name': 'The University of Texas Health Science Center at Houston', 'ror': 'https://ror.org/03gds6c39', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I919571938']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'X. M. Xu', 'raw_affiliation_strings': ['Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I919571938']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007182076', 'display_name': 'Jih‐Luh Tang', 'orcid': 'https://orcid.org/0000-0003-4021-3281'}, 'institutions': [{'id': 'https://openalex.org/I919571938', 'display_name': 'The University of Texas Health Science Center at Houston', 'ror': 'https://ror.org/03gds6c39', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I919571938']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. L. Tang', 'raw_affiliation_strings': ['Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I919571938']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079545097', 'display_name': 'Asghar Hajibeigi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I919571938', 'display_name': 'The University of Texas Health Science Center at Houston', 'ror': 'https://ror.org/03gds6c39', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I919571938']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A. Hajibeigi', 'raw_affiliation_strings': ['Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I919571938']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110192561', 'display_name': 'D. S. Loose-Mitchell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I919571938', 'display_name': 'The University of Texas Health Science Center at Houston', 'ror': 'https://ror.org/03gds6c39', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I919571938']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D. S. Loose-Mitchell', 'raw_affiliation_strings': ['Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I919571938']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035975194', 'display_name': 'Kenneth K. Wu', 'orcid': 'https://orcid.org/0000-0003-2306-6320'}, 'institutions': [{'id': 'https://openalex.org/I919571938', 'display_name': 'The University of Texas Health Science Center at Houston', 'ror': 'https://ror.org/03gds6c39', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I919571938']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K. K. Wu', 'raw_affiliation_strings': ['Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, University of Texas Houston HealthScience Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I919571938']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.633, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 82, 'citation_normalized_percentile': {'value': 0.882669, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '270', 'issue': '1', 'first_page': 'C259', 'last_page': 'C264'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/staurosporine', 'display_name': 'Staurosporine', 'score': 0.7982954}, {'id': 'https://openalex.org/keywords/calphostin-c', 'display_name': 'Calphostin C', 'score': 0.7645972}, {'id': 'https://openalex.org/keywords/calphostin', 'display_name': 'Calphostin', 'score': 0.5635431}, {'id': 'https://openalex.org/keywords/phorbol', 'display_name': 'Phorbol', 'score': 0.5320856}, {'id': 'https://openalex.org/keywords/tetradecanoylphorbol-acetate', 'display_name': 'Tetradecanoylphorbol Acetate', 'score': 0.49276736}], 'concepts': [{'id': 'https://openalex.org/C2778128677', 'wikidata': 'https://www.wikidata.org/wiki/Q412895', 'display_name': 'Cycloheximide', 'level': 3, 'score': 0.8393783}, {'id': 'https://openalex.org/C2779084600', 'wikidata': 'https://www.wikidata.org/wiki/Q5957181', 'display_name': 'Staurosporine', 'level': 4, 'score': 0.7982954}, {'id': 'https://openalex.org/C2780245509', 'wikidata': 'https://www.wikidata.org/wiki/Q5023913', 'display_name': 'Calphostin C', 'level': 4, 'score': 0.7645972}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.7437062}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.6548628}, {'id': 'https://openalex.org/C2777411675', 'wikidata': 'https://www.wikidata.org/wiki/Q1232438', 'display_name': 'Umbilical vein', 'level': 3, 'score': 0.6363418}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.61537635}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5729412}, {'id': 'https://openalex.org/C2781168148', 'wikidata': 'https://www.wikidata.org/wiki/Q5023911', 'display_name': 'Calphostin', 'level': 4, 'score': 0.5635431}, {'id': 'https://openalex.org/C2780043322', 'wikidata': 'https://www.wikidata.org/wiki/Q2705359', 'display_name': 'Phorbol', 'level': 4, 'score': 0.5320856}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5260035}, {'id': 'https://openalex.org/C2909761558', 'wikidata': 'https://www.wikidata.org/wiki/Q416716', 'display_name': 'Tetradecanoylphorbol Acetate', 'level': 4, 'score': 0.49276736}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.46977943}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.46596932}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3577345}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.35499212}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34052354}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.2770178}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2557372}, {'id': 'https://openalex.org/C3675279', 'wikidata': 'https://www.wikidata.org/wiki/Q211935', 'display_name': 'Protein biosynthesis', 'level': 2, 'score': 0.22460938}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16615865}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.16042393}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015152', 'descriptor_name': 'Blotting, Northern', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015335', 'descriptor_name': 'Molecular Probes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015335', 'descriptor_name': 'Molecular Probes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009994', 'descriptor_name': 'Osmolar Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011451', 'descriptor_name': 'Prostaglandin-Endoperoxide Synthases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1996.270.1.c259', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8772452', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.51, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 14, 'referenced_works': ['https://openalex.org/W155521797', 'https://openalex.org/W1561747056', 'https://openalex.org/W1600112913', 'https://openalex.org/W1966183396', 'https://openalex.org/W1973624722', 'https://openalex.org/W1984520701', 'https://openalex.org/W2006120055', 'https://openalex.org/W2014664456', 'https://openalex.org/W2060333964', 'https://openalex.org/W2074293043', 'https://openalex.org/W2085680573', 'https://openalex.org/W2094752831', 'https://openalex.org/W2113745276', 'https://openalex.org/W2409149537'], 'related_works': ['https://openalex.org/W2411310863', 'https://openalex.org/W2408854342', 'https://openalex.org/W2264695441', 'https://openalex.org/W2147355809', 'https://openalex.org/W2078790265', 'https://openalex.org/W2072866545', 'https://openalex.org/W2065201271', 'https://openalex.org/W2028212721', 'https://openalex.org/W2004687011', 'https://openalex.org/W1987150463'], 'abstract_inverted_index': {'Human': [0], 'endothelial': [1, 33], 'cells': [2, 34], 'contain': [3], 'two': [4], 'isoforms': [5], 'of': [6, 23, 87, 94, 103, 120], 'prostaglandin': [7], 'H': [8], 'synthase': [9], '(PGHS).': [10], 'PGHS-1': [11, 24, 47, 60, 95, 104, 122, 142], 'is': [12, 17, 25, 145], 'constitutively': [13], 'expressed,': [14], 'whereas': [15], 'PGHS-2': [16], 'inducible.': [18], 'To': [19], 'determine': [20], 'whether': [21], 'expression': [22], 'regulated,': [26], 'we': [27], 'treated': [28], 'cultured': [29], 'human': [30, 121], 'umbilical': [31], 'vein': [32], '(HUVEC)': [35], 'with': [36], 'phorbol': [37], '12-myristate': [38], '13-acetate': [39], '(PMA)': [40], 'or': [41, 114], 'its': [42], 'inactive': [43], 'analogue': [44], 'and': [45, 53, 70], 'measured': [46], 'mRNA': [48, 61, 74, 105], 'levels': [49, 62, 106], 'by': [50, 64, 100, 109, 131, 148], 'Northern': [51], 'analysis': [52], 'competitive': [54], 'polymerase': [55], 'chain': [56], 'reaction.': [57], 'PMA': [58, 88, 132, 149], 'increased': [59, 77, 99, 125], 'determined': [63], 'both': [65], 'techniques': [66], 'in': [67, 133, 143, 150], 'a': [68, 151], 'time-': [69], 'concentration-dependent': [71], 'manner.': [72, 155], 'The': [73, 92, 117], 'level': [75, 83, 93, 130], 'was': [76, 97, 107, 124], 'about': [78], 'twofold': [79, 126], 'over': [80, 127], 'the': [81, 128, 140], 'basal': [82, 129], 'after': [84], '4-6': [85], 'h': [86], '(10-50': [89], 'nM)': [90], 'treatment.': [91], 'protein': [96, 152], 'similarly': [98], 'PMA.': [101], 'Stimulation': [102], 'abrogated': [108], 'cycloheximide,': [110], 'actinomycin': [111], 'D,': [112], 'staurosporine,': [113], 'calphostin': [115], 'C.': [116], "5'-promoter": [118], 'activity': [119], 'gene': [123], 'NS-20': [134], 'cells.': [135], 'These': [136], 'results': [137], 'indicate': [138], 'that': [139], 'constitutive': [141], 'HUVEC': [144], 'transcriptionally': [146], 'stimulated': [147], 'kinase': [153], 'C-dependent': [154]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2410968240', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-08T11:09:52.408839', 'created_date': '2016-06-24'}