Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2411310863', 'doi': None, 'title': 'Role of protein kinase C in short-term transmission at the mammalian neuromuscular junction.', 'display_name': 'Role of protein kinase C in short-term transmission at the mammalian neuromuscular junction.', 'publication_year': 1992, 'publication_date': '1992-12-01', 'ids': {'openalex': 'https://openalex.org/W2411310863', 'mag': '2411310863', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1335062'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1335062', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004867091', 'display_name': 'Robert V. Considine', 'orcid': 'https://orcid.org/0000-0002-5033-3642'}, 'institutions': [{'id': 'https://openalex.org/I858669146', 'display_name': 'Jefferson College', 'ror': 'https://ror.org/04fcaga30', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I858669146']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R V Considine', 'raw_affiliation_strings': ['Department of Physiology, Jefferson Medical College, Philadelphia, Pennsylvania.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, Jefferson Medical College, Philadelphia, Pennsylvania.', 'institution_ids': ['https://openalex.org/I858669146']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041572902', 'display_name': 'J. R. A. Sherwin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J R Sherwin', 'raw_affiliation_strings': ['Thomas Jefferson University'], 'affiliations': [{'raw_affiliation_string': 'Thomas Jefferson University', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103437875', 'display_name': 'Lance L. Simpson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L L Simpson', 'raw_affiliation_strings': ['Thomas Jefferson University'], 'affiliations': [{'raw_affiliation_string': 'Thomas Jefferson University', 'institution_ids': ['https://openalex.org/I149251103']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.41361, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 65, 'max': 68}, 'biblio': {'volume': '263', 'issue': '3', 'first_page': '1269', 'last_page': '74'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9536, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11274', 'display_name': 'Botulinum Toxin and Related Neurological Disorders', 'score': 0.9512, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/staurosporine', 'display_name': 'Staurosporine', 'score': 0.9329543}, {'id': 'https://openalex.org/keywords/calphostin', 'display_name': 'Calphostin', 'score': 0.8941318}, {'id': 'https://openalex.org/keywords/calphostin-c', 'display_name': 'Calphostin C', 'score': 0.8415166}, {'id': 'https://openalex.org/keywords/phorbol', 'display_name': 'Phorbol', 'score': 0.55732983}], 'concepts': [{'id': 'https://openalex.org/C2779084600', 'wikidata': 'https://www.wikidata.org/wiki/Q5957181', 'display_name': 'Staurosporine', 'level': 4, 'score': 0.9329543}, {'id': 'https://openalex.org/C2781168148', 'wikidata': 'https://www.wikidata.org/wiki/Q5023911', 'display_name': 'Calphostin', 'level': 4, 'score': 0.8941318}, {'id': 'https://openalex.org/C2780245509', 'wikidata': 'https://www.wikidata.org/wiki/Q5023913', 'display_name': 'Calphostin C', 'level': 4, 'score': 0.8415166}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.8257178}, {'id': 'https://openalex.org/C2778703144', 'wikidata': 'https://www.wikidata.org/wiki/Q46298', 'display_name': 'Sphingosine', 'level': 3, 'score': 0.70270336}, {'id': 'https://openalex.org/C2780043322', 'wikidata': 'https://www.wikidata.org/wiki/Q2705359', 'display_name': 'Phorbol', 'level': 4, 'score': 0.55732983}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.49767998}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4964624}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4513081}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3744542}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3682626}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.3020436}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.06491047}], 'mesh': [{'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019307', 'descriptor_name': '1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001905', 'descriptor_name': 'Botulinum Toxins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001905', 'descriptor_name': 'Botulinum Toxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009466', 'descriptor_name': 'Neuromuscular Blocking Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009466', 'descriptor_name': 'Neuromuscular Blocking Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1335062', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2411310863', 'https://openalex.org/W2408854342', 'https://openalex.org/W2357973604', 'https://openalex.org/W2264695441', 'https://openalex.org/W2065201271', 'https://openalex.org/W2044651327', 'https://openalex.org/W2012592975', 'https://openalex.org/W1988273670', 'https://openalex.org/W1987150463', 'https://openalex.org/W1976198643'], 'abstract_inverted_index': {'Neuronal': [0], 'cells': [1, 139, 176], 'grown': [2], 'in': [3, 21, 32, 82, 101, 118, 137, 140, 158, 174, 177, 194, 197], 'culture': [4], 'were': [5, 122], 'exposed': [6], 'to': [7, 155, 168, 171, 233], 'drugs': [8, 110], 'that': [9, 111, 133, 239], 'stimulate': [10], 'protein': [11, 22, 33, 50, 119, 240], 'kinase': [12, 23, 34, 51, 120, 241], 'C': [13, 24, 35, 52, 242], '(phorbol': [14], 'myristate': [15, 44, 105, 143, 206], 'acetate),': [16], 'inhibit': [17, 28, 112], 'the': [18, 29, 79, 83, 98, 102, 113, 169, 216], 'catalytic': [19, 80, 114], 'site': [20, 31, 81, 100], '(H7,': [25], 'staurosporine)': [26], 'or': [27, 211, 230], 'regulatory': [30, 99, 116], '(calphostin,': [36], 'sphingosine).': [37], 'In': [38, 60], 'NG-108': [39], 'and': [40, 72, 85, 91, 115, 182], 'N1E-115': [41], 'cells,': [42, 63], 'phorbol': [43, 142, 205], 'acetate': [45, 144], 'produced': [46, 56], 'substantial': [47], 'stimulation': [48], 'of': [49, 201, 218], 'activity': [53, 136], '(0.1': [54], 'microM': [55], 'approximately': [57, 69, 75, 88, 94], '75%': [58], 'stimulation).': [59], 'these': [61], 'same': [62], 'H7': [64], '[100%': [65], 'inhibition': [66], 'concentration': [67], '(IC100)': [68], '1': [70, 95], 'mM]': [71], 'staurosporine': [73], '(IC100': [74], '0.2': [76], 'microM)': [77, 90, 96], 'inhibited': [78, 97], 'enzyme,': [84], 'calphostin': [86, 181, 210], '(IC80-IC90': [87, 93], '2.0': [89], 'sphingosine': [92, 183, 212], 'enzyme.': [103], 'Phorbol': [104], 'acetate,': [106, 207], 'as': [107, 109], 'well': [108], 'sites': [117], 'C,': [121], 'tested': [123], 'for': [124, 221, 246], 'their': [125], 'effects': [126], 'on': [127], 'phrenic': [128], 'nerve-hemidiaphragm': [129], 'preparations.': [130], 'At': [131, 165], 'concentrations': [132, 166], 'stimulated': [134], 'enzyme': [135], 'neuronal': [138, 175], 'culture,': [141, 178], 'did': [145, 151, 184, 190, 213], 'not': [146, 185, 214, 244], 'augment': [147], 'normal': [148], 'transmission,': [149, 188], 'nor': [150, 189], 'it': [152], 'restore': [153], 'transmission': [154, 193], 'preparations': [156, 203], 'bathed': [157, 196], 'medium': [159], 'with': [160, 204], 'low': [161, 198], 'calcium': [162], '(0.4-0.6': [163], 'mM).': [164], 'equivalent': [167], 'IC80': [170], 'IC100': [172], 'values': [173], 'H7,': [179, 208], 'staurosporine,': [180, 209], 'paralyze': [186, 234], 'short-term': [187, 247], 'they': [191], 'depress': [192], 'tissues': [195], 'calcium.': [199], 'Pretreatment': [200], 'neuromuscular': [202, 248], 'alter': [215], 'amount': [217], 'time': [219], 'necessary': [220], 'botulinum': [222, 226], 'neurotoxin': [223, 227], 'type': [224, 228], 'A,': [225], 'B': [229], 'tetanus': [231], 'toxin': [232], 'transmission.': [235], 'The': [236], 'data': [237], 'indicate': [238], 'is': [243], 'required': [245], 'transmission.(ABSTRACT': [249], 'TRUNCATED': [250], 'AT': [251], '250': [252], 'WORDS)': [253]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2411310863', 'counts_by_year': [{'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-12T19:00:50.656845', 'created_date': '2016-06-24'}