Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2264695441', 'doi': 'https://doi.org/10.1152/ajpheart.1993.264.4.h1300', 'title': 'Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle', 'display_name': 'Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle', 'publication_year': 1993, 'publication_date': '1993-04-01', 'ids': {'openalex': 'https://openalex.org/W2264695441', 'doi': 'https://doi.org/10.1152/ajpheart.1993.264.4.h1300', 'mag': '2264695441', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7682791'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpheart.1993.264.4.h1300', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S87338489', 'display_name': 'AJP Heart and Circulatory Physiology', 'issn_l': '0363-6135', 'issn': ['0363-6135', '1522-1539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112094211', 'display_name': 'Y Shimamoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Y. Shimamoto', 'raw_affiliation_strings': ['Department of Biomedical Sciences, McMaster University, Hamilton,Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences, McMaster University, Hamilton,Ontario, Canada.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108446514', 'display_name': 'H Shimamoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'H. Shimamoto', 'raw_affiliation_strings': ['Department of Biomedical Sciences, McMaster University, Hamilton,Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences, McMaster University, Hamilton,Ontario, Canada.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112189960', 'display_name': 'C.Y. Kwan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'C. Y. Kwan', 'raw_affiliation_strings': ['Department of Biomedical Sciences, McMaster University, Hamilton,Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences, McMaster University, Hamilton,Ontario, Canada.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111376382', 'display_name': 'E. E. Daniel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'E. E. Daniel', 'raw_affiliation_strings': ['Department of Biomedical Sciences, McMaster University, Hamilton,Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences, McMaster University, Hamilton,Ontario, Canada.', 'institution_ids': ['https://openalex.org/I98251732']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.388, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 65, 'citation_normalized_percentile': {'value': 0.677631, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '264', 'issue': '4', 'first_page': 'H1300', 'last_page': 'H1306'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9749, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9749, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13971', 'display_name': 'Synthesis and Biological Activity', 'score': 0.9337, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9177, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/calphostin-c', 'display_name': 'Calphostin C', 'score': 0.9800513}, {'id': 'https://openalex.org/keywords/staurosporine', 'display_name': 'Staurosporine', 'score': 0.89871275}, {'id': 'https://openalex.org/keywords/calphostin', 'display_name': 'Calphostin', 'score': 0.86299205}, {'id': 'https://openalex.org/keywords/phenylephrine', 'display_name': 'Phenylephrine', 'score': 0.77674204}, {'id': 'https://openalex.org/keywords/phorbol', 'display_name': 'Phorbol', 'score': 0.5660565}], 'concepts': [{'id': 'https://openalex.org/C2780245509', 'wikidata': 'https://www.wikidata.org/wiki/Q5023913', 'display_name': 'Calphostin C', 'level': 4, 'score': 0.9800513}, {'id': 'https://openalex.org/C2779084600', 'wikidata': 'https://www.wikidata.org/wiki/Q5957181', 'display_name': 'Staurosporine', 'level': 4, 'score': 0.89871275}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.89707696}, {'id': 'https://openalex.org/C2781168148', 'wikidata': 'https://www.wikidata.org/wiki/Q5023911', 'display_name': 'Calphostin', 'level': 4, 'score': 0.86299205}, {'id': 'https://openalex.org/C2777952589', 'wikidata': 'https://www.wikidata.org/wiki/Q421910', 'display_name': 'Phenylephrine', 'level': 3, 'score': 0.77674204}, {'id': 'https://openalex.org/C163415756', 'wikidata': 'https://www.wikidata.org/wiki/Q126473', 'display_name': 'Contraction (grammar)', 'level': 2, 'score': 0.6230945}, {'id': 'https://openalex.org/C2780043322', 'wikidata': 'https://www.wikidata.org/wiki/Q2705359', 'display_name': 'Phorbol', 'level': 4, 'score': 0.5660565}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.42634633}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42002288}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4166402}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3762605}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.35120872}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3379534}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32121024}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1989764}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D014661', 'descriptor_name': 'Vasoconstriction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019307', 'descriptor_name': '1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000470', 'descriptor_name': 'Alkaloids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000470', 'descriptor_name': 'Alkaloids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010656', 'descriptor_name': 'Phenylephrine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010656', 'descriptor_name': 'Phenylephrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015240', 'descriptor_name': 'Phorbol 12,13-Dibutyrate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015240', 'descriptor_name': 'Phorbol 12,13-Dibutyrate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011083', 'descriptor_name': 'Polycyclic Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011083', 'descriptor_name': 'Polycyclic Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011189', 'descriptor_name': 'Potassium Chloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011189', 'descriptor_name': 'Potassium Chloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014661', 'descriptor_name': 'Vasoconstriction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014661', 'descriptor_name': 'Vasoconstriction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpheart.1993.264.4.h1300', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S87338489', 'display_name': 'AJP Heart and Circulatory Physiology', 'issn_l': '0363-6135', 'issn': ['0363-6135', '1522-1539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7682791', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2411310863', 'https://openalex.org/W2408854342', 'https://openalex.org/W2264695441', 'https://openalex.org/W2147355809', 'https://openalex.org/W2078790265', 'https://openalex.org/W2072866545', 'https://openalex.org/W2065201271', 'https://openalex.org/W2028212721', 'https://openalex.org/W2004687011', 'https://openalex.org/W1987150463'], 'abstract_inverted_index': {'We': [0, 118], 'investigated': [1], 'effects': [2], 'of': [3, 6, 63, 77, 133, 138, 161], 'three': [4], 'kinds': [5], 'putative': [7], 'protein': [8, 143, 168], 'kinase': [9], 'C': [10, 35, 48, 65, 155], '(PKC)': [11], 'inhibitors,': [12], 'calphostin': [13, 47, 64, 154], 'C,': [14], '1-(5-isoquinolinesulfonyl)-2-methylpiperazine': [15], '(H-7),': [16], 'and': [17, 29, 54, 101, 116, 122], 'stauro-sporine,': [18], 'on': [19, 69, 91, 129, 157], 'aortic': [20], 'muscle': [21], 'contractions': [22, 39, 71], 'induced': [23], 'by': [24, 81], 'KCl,': [25, 114], 'phenylephrine,': [26, 115], '12-O-tetradecanoylphorbol-13-acetate': [27], '(TPA),': [28], 'phorbol': [30], '12,': [31], '13-dibutyrate': [32], '(PDBu).': [33], 'Calphostin': [34], 'noncompetitively': [36], 'inhibited': [37, 57, 96, 110], 'TPA-induced': [38, 92], 'in': [40], 'a': [41, 61, 173], 'concentration-dependent': [42], 'manner.': [43], 'At': [44], '10(-6)': [45], 'M,': [46, 105], 'completely': [49], 'abolished': [50], 'responses': [51, 98, 112], 'to': [52, 99, 113, 127], 'TPA': [53], 'also': [55], 'effectively': [56], 'PDBu-induced': [58], 'contractions.': [59], 'Such': [60], 'concentration': [62], 'had': [66, 88], 'no': [67], 'effect': [68, 90], 'KCl-induced': [70], 'but': [72, 94], 'decreased': [73], 'the': [74, 130, 151, 158], 'maximal': [75], 'tension': [76], 'phenylephrine-induced': [78], 'response': [79], 'curve': [80], '35.3': [82], '+/-': [83], '6.6%': [84], 'H-7': [85], '(10(-5)': [86], 'M': [87], 'little': [89], 'contraction': [93], 'significantly': [95], 'contractile': [97, 111], 'phenylephrine': [100], 'KCl.': [102], 'Staurosporine': [103], '(10(-8)': [104], '3': [106], 'x': [107], '10(-8)': [108], 'M)': [109], 'TPA.': [117], 'suggest': [119], 'that': [120], 'staurosporine': [121], 'H-7,': [123], 'which': [124, 163], 'are': [125, 145], 'known': [126], 'act': [128], 'catalytic': [131], 'domain': [132, 160], 'PKC': [134, 177], 'carrying': [135], 'high': [136], 'degree': [137], 'sequence': [139], 'homology': [140], 'with': [141], 'other': [142, 152, 167], 'kinases,': [144, 169], 'relatively': [146, 174], 'nonselective': [147], 'for': [148], 'PKC.': [149], 'On': [150], 'hand,': [153], 'acting': [156], 'regulatory': [159], 'PKC,': [162], 'is': [164], 'distinct': [165], 'from': [166], 'may': [170], 'serve': [171], 'as': [172], 'more': [175], 'selective': [176], 'inhibitor.': [178]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2264695441', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-14T02:06:28.242150', 'created_date': '2016-06-24'}