Title: [Expression of transforming growth factor-β(1) and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma].
Abstract: Objective To investigate the expression and significance of transforming growth factor-β1 (TGF-β1)and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma. Methods The expression of TGF-β1 and Ki-67 nuclear antigen in 20 cases of salivary gland pleomorphic adenoma and 45 cases of mucoepidermoid carcinoma were detected by the streptavidin-peroxidase immunohistochemical method. Results Expression of TGF-β1 (39/45) and Ki-67 nuclear antigen (43/45) in mucoepidermoid carcinoma was significantly higher than in pleomorphic adenoma ( P < 0.05 ). TGF-β1 expression was significantly higher in moderately/poorly differentiated mucoepidermoid carcinoma ( 16/16 ) than that in well differentiated mucoepidermoid carcinoma (23/29) and pleomorphic adenoma (12/20) ( P < 0.05 ), but not different between well differentiated mucoepidermoid carcinoma (6/23) and pleomorphic adenoma (8/12)(P > 0.05 ). The expression of Ki-67 was increased with the increment of TGF-β1 expression in mucoepidermoid carcinoma (P < 0.05 ). Conclusions The high expression of TGF-β1 may play an important role in cell differentiation and malignant proliferation of mucoepidermoid carcinoma.
Key words:
Carcinoma, mucoepidermoid; Transforming growth factor betal; Antigens, nuclear
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 1
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