Title: Expression of EGFR and HER-2 and their clinical significancein salivary gland carcinoma
Abstract: Purpose To evaluate the differences and clinical significances of the expression of EGFR and HER-2 in mucoepidermoid carcinoma,adenoid cystic carcinoma and acinar cell carcinoma. Methods The expression of EGFR and HER-2 proteins in 80 cases of salivary gland carcinoma( including 30 mucoepidermoid carcinomas,30 adenoid cystic carcinomas and 20 acinar cell carcinomas)and 30 cases with pleomorphic adenoma was detected by immunohistochemical method,and the gene amplifications of EGFR and HER-2 in salivary gland carcinoma were detected by fluorescence in situ hybridization. Results The expression rates of EGFR and HER-2proteins in salivary gland carcinoma were 71. 25% and 32. 5% respectively,which were both higher than those in pleomorphic adenoma( P 0. 05). The expression rates of EGFR and HER-2 proteins and intensity of EGFR protein in mucoepidermoid carcinoma were the highest( P 0. 05). There were no significances among different gene,age,maximum diameter,tumor differentiation and tissue subtypes( P 0. 05). There was no significant correlation between the expression of EGFR and HER-2 proteins( rs= 0. 166,P 0. 05). High polysomy amplification of EGFR gene was detected in 15 of 80 cases of salivary gland carcinomas( 18. 75%),including13 cases of mucoepidermoid carcinoma( 43. 3%) and 2 cases of adenoid cyst carcinoma( 6. 7%),but HER-2 gene amplification and17 chromosome polysomy were not detected. EGFR protein intensity in the gene amplification cases were moderately or strongly positive. The positive correlation was showed between EGFR protein intensity and gene amplification( rs= 0. 491,P 0. 01). Compared with EGFR negative /low expression and negative amplification groups,the survival time was significantly shortened in EGFR moderate /strong expression and gene amplification groups( P 0. 05). Conclusions EGFR protein overexpression and its high polysomy amplification in mucoepidermoid carcinoma can be regarded as a target for molecular targeted therapy. HER-2 may not be a suitable target because of its low protein expression and negative gene amplification in mucoepidermoid carcinoma,adenoid cystic carcinoma and acinar cell carcinoma.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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