Title: Relationship between vascular endothelial growth factor C expression level and lymph node metastasis in non small cell lung cancer
Abstract: Objective To investigate the relationship between vascular endothelial growth factor C (VEGF-C) expression level and lymph node metastasis in non small cell lung cancer (NSCLC). Methods Fifty-two NSCLC patients, 38 males and 14 females, aged (59±11) (29-77), were divided into 2 groups based on the pathological examination: lymph node metastasis positive group (n=25) and lymph node metastasis negative group (n=27). RT-PCR and immtmohistochemistry were used to detect the mRNA and protein expression of VEGF-C in the tumor tissues and lymph nodes resectod during operation. Reeults The VEGF-C mRNA expression level in the lung tumor tissue of the lymph node metastasis positive group was 0.273±0.179, significantly higher than that in the lymph node metastasis negative group (0.089± 0.087, P 0.05). The VEGF-C protein positive rate of the lung cancer tissues of the lymph node metastasis positive group was 93.3% ( 14/15 ), significantly higher than that of the lymph node metastasis negative group (6.7%, 1/15, P<0.01). The VEGF-C protein positive rate of the metastasis positive lymph noses was 80.4% (37/46), and all 52 metastasis negative lymph nodes were VEGF-C protein negative. Conclusion VEGF-C mBNA and protein expression levels predict lymph node metastasis and can be useful predictors of lymph node metastasis in NSCLC.
Key words:
Cancer, non-small-cell lung; Vascular endothelial growth factor C; Lymph nodes; Neoplasm metastasis
Publication Year: 2008
Publication Date: 2008-11-18
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 4
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