Title: The Stud y of MTHFR Gene C677T polymorphism in the Case of Cerebral Thrombosis
Abstract: Objective To analysis the MTHFR gene C 67 7T polymorphism in the case of cerebral thrombosis, and investigate the relation between the MTHFR gene polymorphism and cerebral thrombosis.Methods The MTHFR gene polymorphism was detected by polymerase chain reaction-restri ction fragment length polymophism(PCR-RFLP) in 87 patients with cerebral thrombo sis and 80 controls. Results In the cerebral thrombosis group, the frequencies of the genotypes CC, CT, TT were 63.22 %,32.18 %,4.60 % respectivel y, and the frequencies of C, T allele were 79.13 %,20.69 %,Meanwhile those of th e controls were were 66.25 %,30.00 %,3.75 %,81.25 %,78.75 % respectively. Conclusion the MTHFR gene C677T matation is not an independent risk fact or for cerebral thrombosis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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Cited By Count: 1
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