Title: Relation Between MTHFR Gene Polymorphism and Arteriosclerotic Cerebral Infarction
Abstract: In order to detect the relationship between MTHFR gene C677T polymorphism and arteriosclerotic cerebral infarction, this study examined the genotype of 62 patients with arteriosclerotic cerebral infarction and 79 control subjects by PCR-RFLP. The result showed that there was significance difference between patients and control subjects in V allele frequency of MTHFR gene C677T mutation (χ 2 =4.41, P 0.05) and there was no difference between patients and control subjects in genotype frequency of MTHFR gene C677T mutation. The relative risk for arteriosclerotic cerebral infaction of heterozygote ( AV / AA ) was 1.76 and that of homozygote ( VV / AA ) was 3.25. The study confirmed an association between mutated allele of the MTHFR gene C677T and arteriosclerotic cerebral infarction, mutated genotypes increased the risk of arteriosclerotic cerebral infarction.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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Cited By Count: 3
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