Title: Relationship between plasma HCY, polymorphism in MTHFR and cerebral thrombosis
Abstract: Objective To explore the relationship between plasma homocysteine, polymorphism in MTHFR, and the incidence of cerebral thrombosis.Methods 87 patients with acute cerebral thrombosis and 80 controls with no evidence of any vascular events were studied. Plasma HCY level was measured by high-performance liquid chromatography-fluorescence deletion (HPLC-FD) technology. The presence of the C677T MTHFR mutation was determined by a polymerase chain reaction (PCR) assay and subsequent restriction enzyme digestion. Results Plasma HCY levels were higher in the patient group( 15.28 ±4.33umol/L)compared with that in the control group(11.32± 3.86umol/L)(P 0.001) .Individuals homozygous for the C677T MTHFR mutation had significantly higher plasma HCY levels (20.41 ± 3.74umol/L),compared with either heterozygous forms (14.13 ±4.50umol/L) or wild types (12.57 ± 4.19umol/L)(p = 0.0011 and p 0.001). The prevalence of the homozygous C677T mutation was 4.60% in the case group and 3.75% in the control group (p= 0.910).Conclusion A common mutation in MTHFR has been associated with increased plasma HCY levels but not increased risk for acute cerebral thrombosis.Hyperthomocysteinemin is an independent risk factor for cerebral thrombosis.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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