Title: Study on the correlation between contrast-enhanced sonography and MVD in breast cancer
Abstract: Objective To observe the correlation between contrast-enhanced sonography and microvessel density(MVD)in breast cancer.Methods Contrast-enhanced sonography was performed in 49 women with breast cancer before surgery.The time-intensity curve(TIC)on the enhanced images was analyzed quantitatively with computer.Vascular endothelial growth factor(VEGF)expression and MVD tagged by CD34 were measured by immunohistochemistry in the above 49 breast cancers after operation.Parameters of TIC were compared with MVD,VEGF expression,and the correlation were statistically studied.Results The peak intensity and enhancement intensity-index were correlated significantly to MVD and VEGF expression of histological section after operation.The arrived time and peak time were correlated to VEGF expression(P 0.05)but not with MVD(P0.05).The platform time,rise slope rate of the curve were not correlated to MVD and VEGF expression.Conclusion The peak intensity and enhancement intensity-index are correlated significantly to MVD and VEGF expression.They are valuable indexes in evaluating angiogenesis in breast cancer.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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