Title: Expression of RUNX3 mRNA in oral squamous cell carcinoma
Abstract: Objective To detect the mRNA expression of Runt-related transcription factor 3(RUNX3) in oral squamous cell carcinoma(OSCC).Methods Ten normal oral mucosa and 30 OSCC tissues were collected to examinemRNA expression of RUNX3 by RT-PCR analysis;in addition,the relationship between RUNX3 mRNA expression with the differentiation grades was statistically analyzed.Results In 30 OSCC samples,73.3%(22/30) cases showed reduced or absent expression of RUNX3 mRNA.Statistical analysis revealed that the downregulation of RUNX3 mRNA expression was correlated with the differentiation grades in OSCCs(P=0.001).Conclusion Downregulation of RUNX3 occurred frequently in OSCC and played an important role in oral carcinogenesis.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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