Title: Significance of α_1-Microgbulin in Early Diagnosis of Renal Damage Induced by Acute Organophosphorus Pesticide Poisoning in Children
Abstract: Objective To explore the value of α1-microgbulin(α1-MG)in the early diagnosis of toxic renal damage induced by acute organophosphorus pesticide poisoning(AOPP) in children.Methods Eighty-five AOPP children were divided into 3 groups according to the classification criteria for diagnosis of AOPP :light poisoning(LP)group(21 cases),moderate poisoning(MP)group(31 cases) and severe poisoning(HP)group(33 cases);30 healthy children were collected as healthy control group.The α1-MG in blood and urine,blood urea nitrogen(BUN),serum creatinine(Cr) of all the objects were determined.α1-MG content was detected by immunonephelometry in Beckman Array 360 immuno analyzer,BUN and Cr were detected by Beckman CX 7 automatic biochemistry analyzer.Results Blood α1-MG and urine α1-MG in LP group were obviously higher than those in the healthy control group(Pa0.05),BUN and Cr had no significant differences compared with those in the healthy control group(Pa0.05).In MP group and HP group,the blood α1-MG,urine α1-MG,BUN and Cr increased obviously compared with those in the healthy control group(P0.01).In MP group and HP group,the blood α1-MG,urine α1-MG,BUN and Cr,increased obviously compared with those in LP group(Pa0.05,0.01).And in HP group,the blood α1-MG,urine α1-MG,BUN and Cr,increased obviously compared with those in MP group(Pa0.05).Conclusions 1.Blood α1-MG and urine α1-MG may be a sensitive index in the early diagnosis of toxic renal damage induced by AOPP in children,and they are more sensitive than BUN and blood Cr.2.The level of blood and urine α1-MG have certain clinical value and can be the index of the severity and prognosis of AOPP.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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