Title: The quantitative determination and its clinical significance of lymphatic vessel density and microvessel density in laryngeal carcinoma
Abstract: Objective To investigate the lymphatic vessel density(LVD) and microvessel density(MVD) in different laryngeal lesions and the clinical significance of them.Methods Quantitative determination of lymphatic vessel density and microvessel density in laryngeal cancer(n = 40),laryngeal squamous dysplasia(n = 20) and laryngeal papilloma in adults(n = 20) were done.Results Laryngeal squamous cell carcinoma,laryngeal squamous dysplasia and laryngeal papilloma tissue differences between LVD and MVD were statistically significant(P 0.01).LVD and MVD of poorly-differentiated cancer tissue were significantly higher than in well-differentiated cancer tissue;LVD and MVD of TNM Ⅲ-Ⅳ of cancer tissue were significantly higher than the TNMⅠ-Ⅱ cancer tissues,LVD and MVD of with lymph node metastasis in cancer tissues were significantly higher than those without lymph node metastasis in cancer tissues(P 0.01);MVD of supraglottic cancer were significantly higher than the glottic cancer group(P 0.05).LVD,MVD and TNM stage were the independent risk factors for laryngeal squamous cell carcinoma of the survival time of patients(P 0.05).Conclusion The development and transferation of the laryngeal tumor is related to micro lymphatic and capillary density,both are laryngeal negative prognostic factors,quantitative determination of the index can be as a predictor of laryngeal tumor prognosis.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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