Title: Relationship between expression of MKK-4 and MMP-9 genes in primary hepatic carcinoma with or without invasion and metastasis
Abstract: AIM: To investigate the expression of mitogen activated protein kinase kinase 4(MKK-4) and MMP-9 mRNA in primary hepatic carcinoma(PHC),and to analyze its relationship with invasion and metastasis.METHODS: The expression of MKK-4 and MMP-9 mRNA in 34 cases of hepatic carcinoma tissues and adjacent tissues,and in 12 cases of normal liver tissues were detected with RT-PCR.RESULTS:(1) The expression level of MMP-9 mRNA was higher in metastatic cancer tissues than that in other tissuses(P0.01).(2) There was significant statistical difference among the expression level of MKK-4 mRNA,but the level in metastatic cancer was low(P0.01).(3) There was no statistical difference among the expression level of MKK-4 or MMP-9 mRNA among the adjacent tissues and normal tissues(P0.05).(4) MMP-9 mRNA had a tendency to rise as PHC became invasive and metastatic.The expression level of MKK-4 had a tendency to decline in PHC became invasive and metastatic.(5) The expression level of MMP-9 or MKK-4 mRNA had no correlations with tumor volume,or cell differentiation(P0.05).(6) There were correlations between expressions of MKK-4 and MMP-9 mRNA in PHC(Pearson Correlation,r=(-0.925),P0.01).CONCLUSION: There are high MMP-9 mRNA expression and low MKK-4 mRNA expression in PHC.The expression level of MKK-4 or MMP-9 mRNA is correlated with tumor metastasis.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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