Title: The expression and significance of HER2 in uroepithelium cell carcinoma of bladder
Abstract: Objective To study the expression of HER2 in uroepithelium cell carcinoma of bladder,mucosa in the paracarcinoma and normal mucous of urinary bladder,and to explore its correlation with clinic factors,grade and stage of the bladder carcinoma and evaluate whether HER2 can serve as marker to decide the biological behavior of bladder carcinoma.Methods 50 specimens of uroepithelium cell carcinoma of bladder,50 specimens mucosa in the paracarcinoma and 20 cases normal mucous of urinary bladder were collected.The protein expression of HER2 was detected by immunohistochemical staining SP method.Results The expression of HER2 protein in uroepithelium cell carcinoma of bladder tissues was significant higher than that in paracarcinoma mucosa and normal mucous of urinary bladder (P0.05). The expression of HER2 protein in uroepithelium cell carcinoma of bladder tissues had dependablity correlation with the grade and size of the tumors (P0.05).Conclusion The expression of HER2 protein in uroepithelium cell carcinoma of bladder tissues had significant correlation with the grade and size of the tumors. It illustrates that the over expression of HER2 protein maybe had highly correlation with the oncogenesis and development of bladder cancer.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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