Title: Expression and Clinical Significance of Major Histocompatibility Complex Class I Chain-relatived A Protein in Urothelial Carcinoma of Urinary Bladder
Abstract: Objective:To investigate the expression and clinical significance of major histocompatibility complex class Ⅰ chain-relatived A protein(MICA)in urothelial carcinoma of urinary bladder.Methods:MICA expression in 75 urothelial carcinoma tissues and 15 normal mucous membrane tissues of the bladder was detected by immunohistochemistry.The differences between MICA expression in mucous membrane tissues,different grade and stage carcinoma were analyzed by statistics.Results:The expression rates of MICA protein in urothelial carcinoma,noninvasive and invasive urothelial carcinoma were 48.0%,59.0% and 36.1%,respectively.Up-regulation of MICA expression was found in urothelial carcinoma compared with normal mucous membrane tissues(P0.05).There was no significant difference of MICA expression between low grade noninvasive carcinoma and high grade invasive carcinoma.The MICA expression rates of Ta,T1 and T2~4 stage carcinoma were 59.0%,41.2% and 31.6%,respectively.Lower MICA expression was detected in invasive carcinoma(P0.05). Conclusion:Up-regulation of MICA expression may correlate with the tumorigenesis of urinary bladder.Loss of MICA protein may play a role in tumor invasion.MICA protein may be regarded as a putative target for immunotherapy on carcinoma of urinary bladder.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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