Title: Multi-slice Spiral CT Imaging Finding and Tumor Angiogenesis as Prognostic Predictors in Pancreatic Cancer
Abstract: Objective:To evaluate the prognostic values of multislice spiral CT imaging finding and tumor angiogenesis.Methods:36 patients with pancreatic carcinoma underwent CT scanning before resection.Paraffin-embedded specimens from these patients were immunostained for microvascular density(MVD),vascular endothelial growth factor(VEGF),and matrix metalloproteinases(MMP-2,MMP-9).The correlations of CT findings and clinicopathologic feature,the expression of individual angiogenic factors and MVD with prognosis were analysed statistically.Results:In multivariate analysis using the COX model,UICC staging,pathological grade,local invasion and vascular invasion on the CT imaging,MMP-2 were found to be an independent prognostic factor of survival(P0.001,P=0.001,P=0.002,P=0.005,P=0.047,respectively).The relative risks of local invasion and vascular invasion on CT image were 18.18,6.137 respectively.Conclusion:The local invasion and vascular invasion on CT imaging were closely related to patient survival,but the tumor angiogenesis had no correlation with survival.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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