Title: Colorectal carcinoma:correlation between spiral CT perfusion imaging and tumor angiogenesis
Abstract: Objective To evaluate the correlation between spiral CT perfusion imaging in colorectal carcinoma and microvessel density (MVD) and vascular endothelial growth factor (VEGF). Methods Dynamic contrast-enhanced spiral CT was performed in 30 patients with pathologically verified colorectal carcinoma. Time-density curves (TDC) were created from the region of interest drawn over the tumor, target artery by spiral CT with perfusion functional software. MVD, VEGF were evaluated by using immunohistochemical staining of surgical specimens with anti-CD34, anti-VEGF monoclonal antibody. The correlation between MVD, VEGF, and that of the three parameters and clinicopathological factors (Dukes' stages, depth of invasion and lymph node metastasis) was also studied. Results Both perfusion and MVD decreased with increasing Dukes' stage. There was no significant correlation between perfusion and MVD, VEGF expression (r=0.16, 0.19, P0.05), and the parameters of spiral CT perfusion. The positiity rate of VEGF expression was 87%. Perfusion, MVD and VEGF were not associated with invasive depth, metastasis and disease stage. Conclusion Spiral CT perfusion imaging, MVD and VEGF may reflect angiogenic activity, but no significant correlation was found among them.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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