Title: Dynamic Changes of Leptin in Patients with Non-alcoholic Steatohepatitis and Its Intervetion by Chinese Herbal Decoction
Abstract: Objective: To investigate the significance of leptin in patients with non-alcoholic steatohepatitis and its intervetion by Chinese Herbal Decoction( Qushi Huayu Decoction,QHD). Methods: Totally 184 patients with non-alcoholic steatohepatitis were randomized into Chinese intervention group( Qushi Huayu Decoction group,82 cases) and comparison group( Polyene phosphatidyl choline group,82 cases). The course of treatment was 24 weeks. And 30 healthy persons were used as controls. The changes of serum leptin content in the intervention group and comparison group patients were observed before treatment and compared to the normal control group. And dynamic observation of changes in serum leptin content,gamma-glutamyl transpeptidase( GGT) activity and some patients with liver / spleen CT value of the two groups patients was carried on before and after treatment. And the value and significance of serum leptin in patients with non-alcoholic steatohepatitis were studied through correlation analysis of serum leptin content,serum GGT activity and liver / spleen CT value. Results: Serum leptin content of the Chinese intervention group and comparison group patients before treatment were significantly increased compared to that of the normal control group( P 0. 01). After treatment,the serum leptin content and serum GGT activity of both groups were decreased significantly( P 0. 01),and the difference between two groups of serum leptin content and serum GGT activity was statistically significant( P 0. 01),the Chinese intervention group was superior to the comparison group. After treatment,the liver/spleen CT values in some patients of both groups were elevated significantly( P 0. 01),and the difference between two groups of liver / spleen CT values in some patients was statistically significant( P 0. 01). Serum leptin content was positively correlated with serum GGT activity,while it was negatively correlated with liver / spleen CT value. Conclusion: ①Serum leptin content was significantly increased in patients with non-alcoholic steatohepatitis,which was probably play very important roles in pathological mechanisms of non-alcoholic steatohepatitis. ②Qushi Huayu Decoction could redue serum leptin content in patients with non-alcoholic steatohepatitis,and improving hyperleptinemia,which probably is the key mechanism of its treatment effect on non-alcoholic steatohepatitis.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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