Title: Serum leptin and blood lipid levels in male patients with hepatitis B-related cirrhosis
Abstract: Objective To investigate the serum leptin and blood lipids in male patients with hepatitis B-related cirrhosis. Methods Sixty-four male cirrhotic patients with HBV infection and twenty-eight control subjects were included in this study. Serum leptin was determined by ELISA. All data were analyzed by SPSS 10.0 version for Windows. Results Leptin seemed to be increased in patients compared with controls,but there was no statistical significant difference (P0.05). Among the three group patients with liver cirrhosis,the same results could be seen. There was no difference of triglycerides and high density lipoprotein-cholesterol in patients no matter with Child’s A,B or C class as compared with control group (P0.05). The levels of cholesterol and low-density lipoprotein cholesterol were significantly lower in the three group patients than that in controls (P0.01). The levels of CHO and LDL gradually decreased in patients with cirrhosis from Child’s class A to B and C (P0.01). A positive correlation between serum lepin levels and body mass index and Fat% were observed in patients with cirrhosis (BMI:r=0.361,P=0.028;Fat%:r=0.425,P=0.01). A significant positive correlation was also observed in patients without ascites (BMI:r=0.528,P=0.002;Fat%:r=0.538,P=0.002). Conclusions In male patients with hepatitis B-related cirrhosis,there is no obvious association between serum leptin and Child-Pugh’s classes. Leptin can’t serve as an index of evaluating liver function,but it may be a factor resulting in malnutrition in patients. Serum CHO and LDL levels decrease following the impairment of liver function and can be used to monitor the development of the disease as well as to predict the prognosis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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