Title: Clinical analysis of relationship between lipid metabolism and coagulation parameters in the elderly coronary heart disease
Abstract: Objective To investigate the relationship between plasma lipids and coagulation parameters and their roles in the etiology of coronary heart disease(CHD) in the elderly.Methods 220 cases of CHD and 70 cases of normal subjects were included in this study.Plasma lipoprotein(a)[LP(a)],total cholesterol,triglyceride、low density lipoprotein cholesterol(LDL-C)、high density lipoprotein cholesterol(HDL-C)、thrombin-antithrombin Ⅲ complex、D-dimer、fibrinogen were measured.CHD group were divided into single-vessel and multiple-vessel subgroup according to the results of angiography. Results Plasma lipids and levels of fibrinogen,thrombin-antithrombin Ⅲ,D-dimer were significantly higher in patients with CHD than those in controls(P0.05),and the more vessels involved,the higher in those parameters except for HDL-C.Multivariate regression model showed positive correlation between LDL-C, LP(a), fobrinogen and coronary artery disease(OR=1.17, 1.10 and 1.04,P0.05). Conclusions LDL-C,LP(a) and Fibrinogen are independent risk factors of CHD. Surveillance of coagulation parameters is very important to hypercoagulative states,and has preventive effects for coronary heart diseases.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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