Title: HER and COX-2 and NF-κB expressions in non-small cell lung cancer and correlation with survival
Abstract: OBJECTIVE:To study EGFR,HER-2,COX-2 and NF-κB expression status in resected non-small cell lung cancer and analyze the relation with survival. METHODS: The immunohistochemical expressions of EGFR, HER-2, COX-2 and NF-κB were investigated in 114 resected non-small cell lung cancer and correlated with 5-year survival time and clinical data. RESULTS: EGFR, HER-2, COX-2 and NF-κB expression rates were 69.3%(79/114),19.3%(22/114),72.8%(83/114) and 86.8%(99/114) in NSCLC tumors, respectively. The expression rates were similar between squamous carcinoma and adenocarcinoma. None of the markers alone had any impact on survival,P=0.114,0.409,0.162,0.857. However, EGFR (+++)/COX-2 (+++) tumors proved to have a poor prognosis,P=0.001. NF-κB expression was correlated with COX-2 and EGFR expression,P=0.000,0.029. CONCLUSIONS: EGFR, COX-2 and NF-κB are overexpression in non-small cell lung cancer. EGFR (+++)/COX-2 (+++) is proved to be an independent prognostic factor. EGFR combined with COX-2 may be a future treatment target in non-small cell lung cancer.
Publication Year: 2007
Publication Date: 2007-03-01
Language: en
Type: article
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