Title: Combined overexpression of EGFR and estrogen receptor alpha correlates with a poor outcome in lung cancer.
Abstract: The aim of the present study was to determine the prognostic significance of the combined overexpression of epidermal growth factor receptor (EGFR) and estrogen receptor a (ER-alpha) in non-small cell lung cancer (NSCLC).An immunohistochemical assessment of EGFR and ER-alpha expression was carried out in tumor specimens from 122 consecutive NSCLC patients after surgery.Of the 122 tumors examined, 57 (46.7%) overexpressed EGFR, 63 (51.6%) overexpressed ER-alpha, while 33 (27%) overexpressed both EGFR and ER-alpha. Univariate analyses showed that the overexpression of EGFR or ER-alpha correlated with the histological grade (p = 0.01 and p = 0.03, respectively) and a poorer prognosis (p = 0.007), while overexpression of ER-alpha also correlated with smoking (p = 0.02). Multivariate analysis showed the combined overexpression of EGFR and ER-alpha to be an independent indicator of poorer prognosis (p = 0.0006).The combined overexpression of EGFR and ER-alpha in NCLSC patients is predictive of poor outcome and, thus, represents a valuable prognostic factor.
Publication Year: 2005
Publication Date: 2005-12-13
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 56
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