Title: Effect of ambroxol on oxidative stress in rats with acute lung injury
Abstract:Objective:To explore the change of SOD or MDA and protective effects of ambroxol on acute lung injury(ALI) induced by oleicacid in rats.Methods:36 Wistar rats were randomly divided into 3 groups: norm...Objective:To explore the change of SOD or MDA and protective effects of ambroxol on acute lung injury(ALI) induced by oleicacid in rats.Methods:36 Wistar rats were randomly divided into 3 groups: normal control group,oleicacid model group,ambroxol treated group(injected intraperitoneally with 2ml/kg ambroxol at 30 minutes before oleicacid injection).The changes of SOD or MDA in blood and pathlolgichistology were observed.Results:Serum SOD levels in ambroxol treated group(2586±279KU/L) were markedly increased compared with oleicacid model group(1898±256KU/L).Pulmonary tissue damages were diminished by pretreatment with ambroxol.Conclusion:It is suggested that ambroxol have protective effects on the acute lung injury induced by oleicacid,which maybe correlated with the function that ambroxol can inhibite lipidperoxide.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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