Title: The Expression of HIF-1α and VEGF in Gliomas and Its Relationship with Angiogenesis
Abstract: Objective To study the expression of HIF-1α,VEGF and MVD in gliomas,and to explore their relationship with angiogenesis.Methods The expression of HIF-1α,VEGF and MVD was investigated by immunohistochemistry in 43 specimens of gliomas and 5 specimens of normal brains.Results The expressions of VEGF,HIF-1α and MVD increased with the grade of gliomas,and significant difference was found among the grades.The expression of HIF-1α was positively correlated to VEGF and to the expression of MVD.Conclusion The HIF-1α,VEGF expression and MVD can be used as indexes for pathological grade in brain glioma;HIF-1α and VEGF may induce and promote angiogenesis of brain glioma and be incorporated in the glioma invasive growth.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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