Title: The expression of VEGF-C and VEGFR3 in Papillary Thyroid Carcinoma and its significance
Abstract: Objective To observe the expression of VEGF-C and VEGFR3 in Papillary Thyroid Carcinoma and lymphoducts of Papillary Thyroid Carcinoma and to study its correlation,in order to elucidate the mechanism of lymphatic metastasis of cancer cell. Methods To examine the expression of VEGF-C and VEGFR3 in Papillary Thyroid Carcinoma and Thyroid adenimas by immunohistochemical staining, and for comparison and analysis. Results Both VEGF-C and VEGFR3 expressed in Papillary Thyroid Carcinoma and Thyroid adenimas.The rate and intension of VEGF-C and VEGFR3 proteins expression were higher in Papillary Thyroid Carcinoma than in Thyroid adenimas,and the expression of VEGF-C and VEGFR3 in Papillary Thyroid Carcinoma expressed positive correlation. Conclusions The VEGFR3 and VEGF-C in cancer cells of papillary thyroid carcinoma have high intensive expression and have positive correlations with the cancer metastasis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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